(Q36675819)

English

Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells

scientific article published on March 2013

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23061993%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23061993%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

Human Induced Pluripotent Stem Cells

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based on heuristic

inferred from title

long QT syndrome

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author name string

J Jehle

1

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10 March 2020

E Ficker

2

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10 March 2020

X Wan

3

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10 March 2020

I Deschenes

4

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10 March 2020

J Kisselbach

5

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10 March 2020

I Staudacher

7

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10 March 2020

C Schmidt

8

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10 March 2020

P A Schweizer

9

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10 March 2020

R Becker

10

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10 March 2020

D Thomas

12

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10 March 2020

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1 March 2013

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10 March 2020

British Journal of Pharmacology

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10 March 2020

168

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10 March 2020

5

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10 March 2020

1215-1229

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23061993%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

Biological Heart Rate Reduction Through Genetic Suppression of Gα(s) Protein in the Sinoatrial Node

1 reference

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30 September 2017

Guide to Receptors and Channels (GRAC), 5th edition

1 reference

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30 September 2017

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents.

1 reference

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30 September 2017

Novel roles for hERG K(+) channels in cell proliferation and apoptosis

1 reference

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30 September 2017

TASK1 (K(2P)3.1) K(+) channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation

1 reference

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30 September 2017

Antidepressant-induced ubiquitination and degradation of the cardiac potassium channel hERG.

1 reference

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30 September 2017

Carvedilol targets human K2P 3.1 (TASK1) K+ leak channels

1 reference

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30 September 2017

Modelling the long QT syndrome with induced pluripotent stem cells

1 reference

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30 September 2017

Patient-specific induced pluripotent stem-cell models for long-QT syndrome

1 reference

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30 September 2017

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

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30 September 2017

Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine

1 reference

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30 September 2017

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

hERG: protein trafficking and potential for therapy and drug side effects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein

1 reference

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30 September 2017

Use and abuse of QT and TRIaD in cardiac safety research: importance of study design and conduct

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

Doxazosin induces apoptosis of cells expressing hERG K+ channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

Concentrations of scheduled prescription drugs in blood of impaired drivers: considerations for interpreting the results

1 reference

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30 September 2017

Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes

1 reference

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30 September 2017

Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

hERG potassium channels and cardiac arrhythmia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

Newer hypnotic drugs for the short-term management of insomnia: a systematic review and economic evaluation

1 reference

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30 September 2017

Comparative pharmacokinetics and pharmacodynamics of short-acting hypnosedatives: zaleplon, zolpidem and zopiclone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data

1 reference

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30 September 2017

Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

A structural basis for drug-induced long QT syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

Long QT syndromes and torsade de pointes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594678

30 September 2017

Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels

1 reference

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30 September 2017

HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte

1 reference

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30 September 2017

Clinical pharmacokinetics and pharmacodynamics of zolpidem. Therapeutic implications

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30 September 2017

Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?

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28 June 2018

Hypnotic activity of an imidazo-pyridine (zolpidem).

1 reference

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28 June 2018

In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes

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21 January 2018

Pharmacokinetics, pharmacodynamics and the pharmacokinetic/ pharmacodynamic relationship of zolpidem in healthy subjects

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21 January 2018

Mechanisms of arsenic-induced prolongation of cardiac repolarization

1 reference

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21 January 2018

Dynamics and kinetics of a modified-release formulation of zolpidem: comparison with immediate-release standard zolpidem and placebo.

1 reference

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21 January 2018

Starting insomnia treatment: the use of benzodiazepines versus z-hypnotics. A prescription database study of predictors

1 reference

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21 January 2018

QT interval prolongation and Torsades de Pointes in a patient receiving zolpidem and amiodarone

1 reference

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21 January 2018

Repolarization reserve: a moving target

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21 January 2018

Genetic suppression of atrial fibrillation using a dominant-negative ether-a-go-go-related gene mutant

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21 January 2018

hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine

1 reference

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21 January 2018

Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A.

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21 January 2018

Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen

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21 January 2018

Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin

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21 January 2018

Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel trafficking

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21 January 2018

Characterization of recombinant hERG K(+) channel inhibition by the active metabolite of amiodarone desethyl-amiodarone.

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21 January 2018

Suppression of persistent atrial fibrillation by genetic knockdown of caspase 3: a pre-clinical pilot study

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20 September 2018

HERG K+ channel related chemosensitivity to sparfloxacin in colon cancer cells.

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20 September 2018

herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells?

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20 September 2018

HERG K+ channel, a regulator of tumor cell apoptosis and proliferation

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12 December 2020

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Molecular determinants of hERG potassium channel inhibition by disopyramide

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/BPH.12002

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23061993%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23061993%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23061993%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

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