(Q43487048)

23 November 2017

hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine (English)

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23 November 2017

5

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23 November 2017

12

Hugo A Katus

1 reference

23 November 2017

Ingo Staudacher

1

1 reference

23 November 2017

Lu Wang

2

1 reference

23 November 2017

Xiaoping Wan

3

1 reference

23 November 2017

Sabrina Obers

4

1 reference

23 November 2017

Frank Tristram

6

1 reference

23 November 2017

Ronald Koschny

7

1 reference

23 November 2017

Kathrin Staudacher

8

1 reference

23 November 2017

Jana Kisselbach

9

1 reference

23 November 2017

Patrick Koelsch

10

1 reference

23 November 2017

Patrick A Schweizer

11

1 reference

23 November 2017

Eckhard Ficker

13

1 reference

23 November 2017

Dierk Thomas

14

1 reference

23 November 2017

1 December 2010

1 reference

Naunyn-Schmiedeberg's Archives of Pharmacology

23 November 2017

1 reference

23 November 2017

383

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23 November 2017

119-139

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23 November 2017

2

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https://scigraph.springernature.com/pub.10.1007/s00210-010-0583-9

23 November 2017

0 references

cites work

A double-blind placebo controlled study of desipramine in the treatment ADD: II. Serum drug levels and cardiovascular findings

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Electrocardiographic safety profile and monitoring guidelines in pediatric psychopharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Second generation antidepressants: a comparative review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Pentamidine reduces hERG expression to prolong the QT interval

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

The role of catecholamines in the production of ischaemia-induced ventricular arrhythmias in the rat in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

An in vitro model for assessment of drug-induced torsade de pointes arrhythmia : effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Cardiac toxicity in an adolescent following chronic lithium and imipramine therapy

21 January 2018

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Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms.

21 January 2018

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Solvation energy in protein folding and binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Mechanisms of arsenic-induced prolongation of cardiac repolarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Channel-mediated water movement across enclosed or perfused mouse intrahepatic bile duct units.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Use and abuse of QT and TRIaD in cardiac safety research: importance of study design and conduct

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

X-ray structure of a voltage-dependent K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Flexible side chain models improve enrichment rates in in silico screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Pentamidine-induced long QT syndrome and block of hERG trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

A structural basis for drug-induced long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

The QT syndromes: long and short

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

N-linked glycosylation sites determine HERG channel surface membrane expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Endocytic control of ion channel density as a target for cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Repolarization reserve: a moving target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

hERG potassium channels and cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Role of poly(ADP-ribose) formation in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Antiarrhythmic drug-induced internalization of the atrial-specific k+ channel kv1.5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Refining detection of drug-induced proarrhythmia: QT interval and TRIaD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Clomipramine vs desipramine vs placebo in the treatment of diabetic neuropathy symptoms. A double-blind cross-over study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Adrenergic regulation of the rapid component of the cardiac delayed rectifier potassium current, I(Kr), and the underlying hERG ion channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

The cardiac hERG/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Doxazosin induces apoptosis of cells expressing hERG K+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Long QT syndromes and torsade de pointes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

A family of potassium channel genes related to eag in Drosophila and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Stochastic Tunneling Approach for Global Minimization of Complex Potential Energy Landscapes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Psychotropic drugs, cardiac arrhythmia, and sudden death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Inhibition of the cardiac L-type calcium channel current by antidepressant drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00210-010-0583-9

Accuracy of binding mode prediction with a cascadic stochastic tunneling method

21 January 2018

1 reference

12 December 2020

Desipramine dose prediction based on 24-hour single-dose levels: feasibility and validity

1 reference

12 December 2020

Antiarrhythmic efficacy of desipramine

1 reference

12 December 2020

Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group

1 reference

12 December 2020

The mechanism of activity-dependent sodium channel inhibition by the antidepressants fluoxetine and desipramine

1 reference

12 December 2020

The use of imipramine in depressed patients with congestive heart failure

1 reference

12 December 2020

Role of glycosylation in cell surface expression and stability of HERG potassium channels

1 reference

12 December 2020

hERG: protein trafficking and potential for therapy and drug side effects.

1 reference

12 December 2020

Cardiovascular effects of desipramine in children and adults during exercise testing

1 reference

12 December 2020

Torsade de pointes caused by tricyclic antidepressive agents. Description of a clinical case

1 reference

12 December 2020

QT prolongation is an unreliable predictor of ventricular arrhythmia

1 reference

12 December 2020

Electrocardiographic changes during desipramine and clomipramine treatment in children and adolescents

1 reference

12 December 2020

HERG K+ channel related chemosensitivity to sparfloxacin in colon cancer cells.

1 reference

12 December 2020

Tricyclic medication in children and the QT interval: case report and discussion.

1 reference

12 December 2020

Nonexocytotic noradrenaline release and ventricular fibrillation in ischemic rat hearts

1 reference

12 December 2020

HERG K+ channel, a regulator of tumor cell apoptosis and proliferation

1 reference

12 December 2020

Cardiovascular Effects of Tricyclic and Tetracyclic Antidepressants

1 reference

12 December 2020

High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872.

1 reference

12 December 2020

Steady-state levels of imipramine and its metabolites: significance of dose-dependent kinetics

1 reference

12 December 2020

Death of two subjects due to imipramine and desipramine metabolite accumulation during chronic therapy: a review of the literature and possible mechanisms.

1 reference

12 December 2020

herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells?

1 reference

12 December 2020

A case of severe acute desipramine overdose

1 reference

12 December 2020

10.1007/S00210-010-0583-9

Identifiers

DOI

1 reference

23 November 2017

1 reference