(Q36679193)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17159922%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

review article

1 reference

title

Multi-targeting by monotherapeutic antibacterials (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17159922%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17159922%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

author name string

Lynn L Silver

series ordinal

1

1 reference

15 August 2017

publication date

1 January 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17159922%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

22 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17159922%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17159922%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17159922%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

page(s)

41-55

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17159922%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrd2202

22 December 2019

exact match

0 references

cites work

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21 January 2018

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Affinities of penicillins and cephalosporins for the penicillin-binding proteins of Escherichia coli K-12 and their antibacterial activity

21 January 2018

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Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus

21 January 2018

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Transferable vancomycin and teicoplanin resistance in Enterococcus faecium

21 January 2018

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Effects of novobiocin, coumermycin A1, clorobiocin, and their analogs on Escherichia coli DNA gyrase and bacterial growth

21 January 2018

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Mechanisms of action of cephalosporin 3'-quinolone esters, carbamates, and tertiary amines in Escherichia coli

21 January 2018

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Escherichia coli resistant to cephalosporins and quinolones is still susceptible to the cephalosporin-quinolone ester Ro 23-9424

21 January 2018

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Mining bacterial genomes for antimicrobial targets

21 January 2018

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Exploiting genomics to discover new antibiotics

31 March 2020

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When will the genomics investment pay off for antibacterial discovery?

31 March 2020

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Use of genomics to select antibacterial targets

31 March 2020

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Origin and evolution of the AmpC beta-lactamases of Citrobacter freundii

31 March 2020

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Resistance to antibiotics mediated by target alterations

31 March 2020

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Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus.

31 March 2020

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Protein synthesis as a target for antibacterial drugs: current status and future opportunities

31 March 2020

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Crystallizing new approaches for antimicrobial drug discovery

31 March 2020

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Biological costs and mechanisms of fosfomycin resistance in Escherichia coli

31 March 2020

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Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.

31 March 2020

1 reference

Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteria

31 March 2020

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Mutation frequencies and antibiotic resistance

31 March 2020

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Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in cell wall mucopeptide synthesis

31 March 2020

1 reference

Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine

31 March 2020

1 reference

Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12

31 March 2020

1 reference

Complementation of the essential peptidoglycan transpeptidase function of penicillin-binding protein 2 (PBP2) by the drug resistance protein PBP2A in Staphylococcus aureus

31 March 2020

1 reference

Cloning, characterization, and inactivation of the gene pbpC, encoding penicillin-binding protein 3 of Staphylococcus aureus

31 March 2020

1 reference

Role of interspecies transfer of chromosomal genes in the evolution of penicillin resistance in pathogenic and commensal Neisseria species

31 March 2020

1 reference

Evolution of penicillin resistance in Streptococcus pneumoniae; the role of Streptococcus mitis in the formation of a low affinity PBP2B in S. pneumoniae

31 March 2020

1 reference

Estimating the relative contributions of mutation and recombination to clonal diversification: a comparison between Neisseria meningitidis and Streptococcus pneumoniae

31 March 2020

1 reference

Recruitment of the mecA gene homologue of Staphylococcus sciuri into a resistance determinant and expression of the resistant phenotype in Staphylococcus aureus.

31 March 2020

1 reference

The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus

31 March 2020

1 reference

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

31 March 2020

1 reference

The structures of four macrolide antibiotics bound to the large ribosomal subunit

31 March 2020

1 reference

Inactivation of antibiotics and the dissemination of resistance genes

31 March 2020

1 reference

A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503.

31 March 2020

1 reference

The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics

31 March 2020

1 reference

Distribution of florfenicol resistance genes fexA and cfr among chloramphenicol-resistant Staphylococcus isolates

31 March 2020

1 reference

On the nature of antibiotic binding sites in ribosomes

31 March 2020

1 reference

rrndb: the Ribosomal RNA Operon Copy Number Database

31 March 2020

1 reference

Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes ofEscherichia coli

31 March 2020

1 reference

Mycobacteria possess a surprisingly small number of ribosomal RNA genes in relation to the size of their genome

31 March 2020

1 reference

Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis.

31 March 2020

1 reference

Molecular mechanisms of clarithromycin resistance in Mycobacterium avium: observation of multiple 23S rDNA mutations in a clonal population

31 March 2020

1 reference

Resistance to linezolid: characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci

31 March 2020

1 reference

Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis

31 March 2020

1 reference

Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America

31 March 2020

1 reference

Epidemiology of macrolide and/or lincosamide resistant Streptococcus pneumoniae clinical isolates with ribosomal mutations

31 March 2020

1 reference

Macrolide resistance by ribosomal mutation in clinical isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 study

31 March 2020

1 reference

Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage

31 March 2020

1 reference

In vitro selection and characterization of resistance to macrolides and related antibiotics in Mycoplasma pneumoniae.

31 March 2020

1 reference

Ribosomal protein gene sequence changes in erythromycin-resistant mutants of Escherichia coli

31 March 2020

1 reference

Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae

31 March 2020

1 reference

Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23 S ribosomal RNA.

31 March 2020

1 reference

High Rate of Macrolide Resistance inStaphylococcus aureusStrains from Patients with Cystic Fibrosis Reveals High Proportions of Hypermutable Strains

31 March 2020

1 reference

Clinical isolates of Staphylococcus aureus with ribosomal mutations conferring resistance to macrolides

31 March 2020

1 reference

DNA gyrase: an enzyme that introduces superhelical turns into DNA

31 March 2020

1 reference

1,8-Naphthyridine Derivatives. A New Class of Chemotherapeutic Agents

31 March 2020

1 reference

Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity

31 March 2020

1 reference

Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme

31 March 2020

1 reference

Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones

31 March 2020

1 reference

DNA gyrase and topoisomerase IV on the bacterial chromosome: quinolone-induced DNA cleavage.

31 March 2020

1 reference

Topoisomerase IV is a target of quinolones in Escherichia coli

31 March 2020

1 reference

Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance

31 March 2020

1 reference

Primary targets of fluoroquinolones in Streptococcus pneumoniae.

31 March 2020

1 reference

Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition

31 March 2020

1 reference

Mechanisms of action and resistance of older and newer fluoroquinolones

31 March 2020

1 reference

Dual targeting of topoisomerase IV and gyrase to reduce mutant selection: direct testing of the paradigm by using WCK-1734, a new fluoroquinolone, and ciprofloxacin

31 March 2020

1 reference

In vitro development of resistance to six quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus

31 March 2020

1 reference

Restricting the selection of antibiotic-resistant mutants: a general strategy derived from fluoroquinolone studies

31 March 2020

1 reference

Structure, biochemistry and mechanism of action of glycopeptide antibiotics

31 March 2020

1 reference

Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala.

31 March 2020

1 reference

Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms

31 March 2020

1 reference

Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation

31 March 2020

1 reference

Ramoplanin: a lipoglycodepsipeptide antibiotic

31 March 2020

1 reference

Targeting extracellular pyrophosphates underpins the high selectivity of nisin

31 March 2020

1 reference

In vivo efficacy and pharmacokinetics of AC98-6446, a novel cyclic glycopeptide, in experimental infection models

31 March 2020

1 reference

Correlation of daptomycin bactericidal activity and membrane depolarization in Staphylococcus aureus

31 March 2020

1 reference

Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus

31 March 2020

1 reference

Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine

31 March 2020

1 reference

Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus.

31 March 2020

1 reference

Synthesis and properties of 2-(naphthosultamyl)methyl-carbapenems with potent anti-MRSA activity: discovery of L-786,392.

31 March 2020

1 reference

In vitro activities of ME1036 (CP5609), a novel parenteral carbapenem, against methicillin-resistant staphylococci

31 March 2020

1 reference

RWJ-54428 (MC-02,479), a new cephalosporin with high affinity for penicillin-binding proteins, including PBP 2a, and stability to staphylococcal beta-lactamases

31 March 2020

1 reference

Ceftobiprole: in-vivo profile of a bactericidal cephalosporin

31 March 2020

1 reference

Anti-MRSA beta-lactams in development

31 March 2020

1 reference

In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599.

31 March 2020

1 reference

In vitro and in vivo antibacterial activities of CS-023 (RO4908463), a novel parenteral carbapenem

31 March 2020

1 reference

Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance

31 March 2020

1 reference

Functional, biophysical, and structural bases for antibacterial activity of tigecycline

31 March 2020

1 reference

Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936).

31 March 2020

1 reference

Tigecycline: a critical analysis

31 March 2020

1 reference

Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1.

31 March 2020

1 reference

Ketolides lack inducibility properties of MLS(B) resistance phenotype

31 March 2020

1 reference

Structure-activity relationships of ketolides vs. macrolides

31 March 2020

1 reference

The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA.

31 March 2020

1 reference

Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants

31 March 2020

1 reference

Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance

31 March 2020

1 reference

Structure-based drug design meets the ribosome

31 March 2020

1 reference

Design of novel antibiotics that bind to the ribosomal acyltransfer site

31 March 2020

1 reference

The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography

31 March 2020

1 reference

Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase

31 March 2020

1 reference

Isolation and characterisation of a strain carrying a conditional lethal mutation in the cou gene of Escherichia coli K12

31 March 2020

1 reference

The interaction between coumarin drugs and DNA gyrase

31 March 2020

1 reference

Accumulation of mutations in both gyrB and parE genes is associated with high-level resistance to novobiocin in Staphylococcus aureus

31 March 2020

1 reference

Clinical and laboratory studies of novobiocin, a new antibiotic

31 March 2020

1 reference

Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase

31 March 2020

1 reference

In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class

31 March 2020

1 reference

Hydroxyphenylazopyrimidines: Characterization of the Active Forms and Their Inhibitory Action on a DNA Polymerase from Bacillus subtilis

31 March 2020

1 reference

Inhibition of a DNA Polymerase from Bacillus subtilis by Hydroxyphenylazopyrimidines

31 March 2020

1 reference

In vitro antimicrobial activities of novel anilinouracils which selectively inhibit DNA polymerase III of gram-positive bacteria

31 March 2020

1 reference

Low frequencies of resistance among Staphylococcus and Enterococcus species to the bactericidal DNA polymerase inhibitor N(3)-hydroxybutyl 6-(3'-ethyl-4'-methylanilino) uracil

31 March 2020

1 reference

Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils

31 March 2020

1 reference

Biological characterization of novel inhibitors of the gram-positive DNA polymerase IIIC enzyme

31 March 2020

1 reference

Active site directed inhibitors of replication-specific bacterial DNA polymerases

31 March 2020

1 reference

RO 23-9424, a new cephalosporin 3'-quinolone: in-vitro antimicrobial activity and tentative disc diffusion interpretive criteria.

31 March 2020

1 reference

Structure–activity relationship in the oxazolidinone–quinolone hybrid series: influence of the central spacer on the antibacterial activity and the mode of action

31 March 2020

1 reference

Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors

31 March 2020

1 reference

Glycopeptides: Update on an old successful antibiotic class

31 March 2020

1 reference

Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureus

31 March 2020

1 reference

Multidrug-resistant Mycobacterium tuberculosis: molecular perspectives

31 March 2020

1 reference

Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update

31 March 2020

1 reference

The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria

31 March 2020

1 reference

Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs

31 March 2020

1 reference

Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus

31 March 2020

1 reference

The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase

31 March 2020

1 reference

Evolution of drug resistance in Mycobacterium tuberculosis: clinical and molecular perspective

31 March 2020

1 reference

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

31 March 2020

1 reference

Guidelines for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the UK.

31 March 2020

1 reference

Society for Healthcare Epidemiology of America and Infectious Diseases Society of America Joint Committee on the Prevention of Antimicrobial Resistance: guidelines for the prevention of antimicrobial resistance in hospitals

31 March 2020

1 reference

Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria

31 March 2020

1 reference

Screening of natural products for antimicrobial agents.

31 March 2020

1 reference

MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.II. INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS.

31 March 2020

1 reference