(Q36709232)

English

An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK

scientific article published on April 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

author name string

Tae Hyun Kim

1

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Jeong Sik Eom

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Chan Gyu Lee

3

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Yoon Mee Yang

4

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Yong Sup Lee

5

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Sang Geon Kim

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

language of work or name

0 references

publication date

1 April 2013

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

British Journal of Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

168

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

7

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

1647-1661

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction

1 reference

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The role of thiazolidinediones in non-alcoholic steatohepatitis - a systematic review and meta analysis.

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Animal research: reporting in vivo experiments: the ARRIVE guidelines

1 reference

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30 September 2017

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

1 reference

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Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis

1 reference

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PPARalpha: energy combustion, hypolipidemia, inflammation and cancer

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Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications

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AMPK: an emerging drug target for diabetes and the metabolic syndrome

1 reference

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AMPK: a metabolic gauge regulating whole-body energy homeostasis

1 reference

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Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome

1 reference

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Inhibition of arachidonic acid and iron-induced mitochondrial dysfunction and apoptosis by oltipraz and novel 1,2-dithiole-3-thione congeners

1 reference

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High-fat diets cause insulin resistance despite an increase in muscle mitochondria

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Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention

1 reference

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Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway

1 reference

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Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation

1 reference

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30 September 2017

Differential effects of the oxidized metabolites of oltipraz on the activation of CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 for GSTA2 gene induction

1 reference

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Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

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Liver X receptors as integrators of metabolic and inflammatory signaling

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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30 September 2017

Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz

1 reference

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30 September 2017

Autoregulation of the human liver X receptor alpha promoter

1 reference

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Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia

1 reference

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Fatty acid import into mitochondria

1 reference

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Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

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Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression

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Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice.

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Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation.

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Pharmacokinetics of Oltipraz and Its Major Metabolite (RM) in Patients With Liver Fibrosis or Cirrhosis: Relationship With Suppression of Circulating TGF-β1

1 reference

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Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation.

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Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones

1 reference

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1 reference

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Transient intervention with oltipraz protects against aflatoxin-induced hepatic tumorigenesis

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23145499

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A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis

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Identifiers

10.1111/BPH.12057

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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