(Q36725226)

15 August 2017

1 reference

title

Intestinal UGTs as potential modifiers of pharmacokinetics and biological responses to drugs and xenobiotics (English)

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15 August 2017

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Joseph K Ritter

1

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15 August 2017

language of work or name

English

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publication date

1 February 2007

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Expert Opinion on Drug Metabolism & Toxicology

15 August 2017

published in

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15 August 2017

volume

3

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15 August 2017

issue

1

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15 August 2017

page(s)

93-107

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Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Role of gut in xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

UDP-glucuronosyltransferase activity in human liver and colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

First-pass elimination. Basic concepts and clinical consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

First-pass effect: significance of the intestine for absorption and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Pharmacokinetic interpretation of the enterohepatic recirculation and first-pass elimination of morphine in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Comparison of the activity and disposition of the novel cholesterol absorption inhibitor, SCH58235, and its glucuronide, SCH60663

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Disposition and metabolism of [2-14C]quercetin-4'-glucoside in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Metabolism of flavonoids via enteric recycling: role of intestinal disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

The splanchnic metabolism of flavonoids highly differed according to the nature of the compound.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Extrahepatic morphine metabolism in man during the anhepatic phase of orthotopic liver transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Changes in apparent systemic clearance of propofol during transplantation of living related donor liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: relationship between UGT1A1 promoter genotype and variability in a liver bank

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Carboxyl nonsteroidal anti-inflammatory drugs are efficiently glucuronidated by microsomes of the human gastrointestinal tract.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Clinical pharmacokinetics of mycophenolate mofetil

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

In vitro-in vivo correlations for drugs eliminated by glucuronidation: investigations with the model substrate zidovudine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Altered AZT (3'-azido-3'-deoxythymidine) glucuronidation kinetics in liver microsomes as an explanation for underprediction of in vivo clearance: comparison to hepatocytes and effect of incubation environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

The effect of incubation conditions on the enzyme kinetics of udp-glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Mycophenolate mofetil is effective and well tolerated in the treatment of refractory acute and chronic graft-versus-host disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Pharmacokinetic mechanisms for reduced toxicity of irinotecan by coadministered thalidomide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

A possible mechanism of gastrointestinal toxicity posed by mycophenolic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Glucuronidation by human colorectal adenocarcinoma cells as a mechanism of resistance to mycophenolic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Adenovirus-mediated gene therapy to restore expression and functionality of multiple UDP-glucuronosyltransferase 1A enzymes in Gunn rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Hepatic and extrahepatic glucuronidation of bile acids in man. Characterization of bile acid uridine 5'-diphosphate-glucuronosyltransferase in hepatic, renal, and intestinal microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

The glucuronidation of mycophenolic acid by human liver, kidney and jejunum microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Resveratrol is efficiently glucuronidated by UDP-glucuronosyltransferases in the human gastrointestinal tract and in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Cloning and expression of human UDP-glucuronosyltransferase (UGT) 1A8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Identification of bilirubin UDP-GTs in the human alimentary tract in accordance with the gut as a putative metabolic organ

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Characterization of two UDP glucuronosyltransferases that are predominantly expressed in human colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Regulation of UDP glucuronosyltransferases in the gastrointestinal tract.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Coordinate regulation of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 genes by hepatocyte nuclear factor 1alpha and the caudal-related homeodomain protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Evidence for phosphorylation requirement for human bilirubin UDP-glucuronosyltransferase (UGT1A1) activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Pharmacokinetics of intravenous and oral dihydrocodeine and its acid metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Glucuronidation of dihydrocodeine by human liver microsomes and the effect of inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Pharmacokinetic drug data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Correlation of plasma clearance of 54 extensively metabolized drugs between humans and rats: mean allometric coefficient of 0.66.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human udp-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Determination of drug glucuronidation and UDP-glucuronosyltransferase selectivity using a 96-well radiometric assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Glucuronidation of Etoposide in Human Liver Microsomes Is Specifically Catalyzed by UDP-Glucuronosyltransferase 1A1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Prominent but reverse stereoselectivity in propranolol glucuronidation by human UDP-glucuronosyltransferases 1A9 and 1A10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Etodolac clinical pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Pharmacokinetics of sustained-release etodolac

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Influence of nonsynonymous polymorphisms of UGT1A8 and UGT2B7 metabolizing enzymes on the formation of phenolic and acyl glucuronides of mycophenolic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Metabolism and bioavailability of trans-resveratrol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Glucuronidation of trans-resveratrol by human liver and intestinal microsomes and UGT isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

High absorption but very low bioavailability of oral resveratrol in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Differential and Special Properties of the Major Human UGT1-encoded Gastrointestinal UDP-glucuronosyltransferases Enhance Potential to Control Chemical Uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Resveratrol Is Absorbed in the Small Intestine as Resveratrol Glucuronide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

Epicatechin and Catechin are O-Methylated and Glucuronidated in the Small Intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.3.1.93

21 January 2018

Identifiers

DOI

10.1517/17425255.3.1.93

1 reference

15 August 2017

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