(Q41684485)

7 October 2017

1 reference

title

First-pass effect: significance of the intestine for absorption and metabolism (English)

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7 October 2017

Doherty MM

1

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7 October 2017

Pang KS

series ordinal

2

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7 October 2017

publication date

1 November 1997

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Drug and Chemical Toxicology

7 October 2017

published in

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7 October 2017

volume

20

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7 October 2017

issue

4

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7 October 2017

page(s)

329-344

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Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2).

7 October 2017

cites work

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Development of Caco-2 cells expressing high levels of cDNA-derived cytochrome P4503A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

A drug absorption model based on the mucus layer producing human intestinal goblet cell line HT29-H.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Improving intestinal absorption of water-insoluble compounds: a membrane metabolism strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Characterization of the oral absorption of beta-lactam antibiotics. I. Cephalosporins: determination of intrinsic membrane absorption parameters in the rat intestine in situ.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Destruction of chlorpromazine during absorption in the rat in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Intestinal metabolism of ethinyloestradiol and paracetamol in vitro: studies using Ussing chambers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

The absorption and first-pass metabolism of [14C]-1,3-dinitrobenzene in the isolated vascularly perfused rat small intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

In vivo assessment of intestinal, hepatic, and pulmonary first pass metabolism of propofol in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

The relationship between rat intestinal permeability and hydrophilic probe size

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Characterization of fluids from the stomach and proximal jejunum in men and women.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Direct effect of bile salts and phospholipids on the physical properties of mucus

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Gastric acid inactivation of erythromycin stearate in solid dosage forms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Kinetic analysis of penicillin degradation in acidic media

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Drugs, diseases and altered gastric emptying

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and beta-lactam antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Mechanisms of the human intestinal H+-coupled oligopeptide transporter hPEPT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Interaction of taurine on baclofen intestinal absorption: a nonlinear mathematical treatment using differential equations to describe kinetic inhibition models.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Carrier-mediated intestinal transport of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Inhibition of intestinal P-glycoprotein and effects on etoposide absorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Multidrug resistance in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Dose-dependent intestinal absorption and significant intestinal excretion (exsorption) of the beta-blocker pafenolol in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

The contribution of intestinal secretion to the dose-dependent absorption of celiprolol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Intestinal microsomal drug metabolism. A comparison of rat and guinea-pig enzymes, and of rat crypt and villous tip cell enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Metabolism of drugs and other xenobiotics in the gut lumen and wall

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Extrahepatic metabolism of drugs in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

The effect of enzymatic reaction on dissolution rate: theoretical analysis and experimental test.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Erythromycin enhances the absorption of cyclosporin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Effect of 'unstirred' water layer in the intestine on the rate and extent of absorption after oral administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

First-pass metabolism of midazolam by the human intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Extrahepatic metabolism of morphine occurs in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

Decreased intestinal CYP3A in celiac disease: Reversal after successful gluten-free diet: A potential source of interindividual variability in first-pass drug metabolism*

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549709003891

10.3109/01480549709003891

21 January 2018

Identifiers

DOI

1 reference

7 October 2017

1 reference