(Q36734919)

16 August 2017

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title

Antimalarial drug discovery: targeting protein kinases (English)

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16 August 2017

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Christian Doerig

1

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Laurent Meijer

series ordinal

2

object named as

Laurent Meijer

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16 August 2017

language of work or name

English

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publication date

1 March 2007

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Expert Opinion on Therapeutic Targets

16 August 2017

published in

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16 August 2017

volume

11

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16 August 2017

issue

3

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16 August 2017

page(s)

279-290

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The economic and social burden of malaria

16 August 2017

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Human members of the eukaryotic protein kinase family

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Protein kinases--the major drug targets of the twenty-first century?

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The design of drug candidate molecules as selective inhibitors of therapeutically relevant protein kinases

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Protein kinases as targets for anti-parasitic chemotherapy

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Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes

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Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone

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A new Apicomplexa-specific protein kinase family: multiple members in Plasmodium falciparum, all with an export signature

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A novel protein kinase family in Plasmodium falciparum is differentially transcribed and secreted to various cellular compartments of the host cell

21 January 2018

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Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi

21 January 2018

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Calcium signaling through protein kinases. The Arabidopsis calcium-dependent protein kinase gene family.

21 January 2018

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A MAP kinase homologue from the human malaria parasite, Plasmodium falciparum

21 January 2018

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An atypical mitogen-activated protein kinase (MAPK) homologue expressed in gametocytes of the human malaria parasite Plasmodium falciparum. Identification of a MAPK signature.

21 January 2018

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21 January 2018

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Stage-specific expression of a Plasmodium falciparum protein related to the eukaryotic mitogen-activated protein kinases

21 January 2018

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The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum

21 January 2018

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Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum Biochemical properties and possible involvement in MAPK regulation.

21 January 2018

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Gene targeting in malaria parasites

21 January 2018

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Pfmrk, a MO15-related protein kinase from Plasmodium falciparum. Gene cloning, sequence, stage-specific expression and chromosome localization

21 January 2018

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Targeting malaria with specific CDK inhibitors.

21 January 2018

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Rational inhibitor design and iterative screening in the identification of selective plasmodial cyclin dependent kinase inhibitors.

21 January 2018

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Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp.

21 January 2018

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A mitogen-activated protein kinase regulates male gametogenesis and transmission of the malaria parasite Plasmodium berghei

21 January 2018

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An atypical mitogen-activated protein kinase controls cytokinesis and flagellar motility during male gamete formation in a malaria parasite

21 January 2018

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Sexual stage-specific expression of a third calcium-dependent protein kinase from Plasmodium falciparum.

21 January 2018

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Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

21 January 2018

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Isolation and expression of a gene specifying a cdc2-like protein kinase from the human malaria parasite Plasmodium falciparum

21 January 2018

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21 January 2018

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21 January 2018

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The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes

21 January 2018

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PfPKB, a protein kinase B-like enzyme from Plasmodium falciparum: II. Identification of calcium/calmodulin as its upstream activator and dissection of a novel signaling pathway

21 January 2018

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Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

21 January 2018

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A study of selected Plasmodium yoelii messenger RNAs during hepatocyte infection.

21 January 2018

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Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite

21 January 2018

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21 January 2018

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21 January 2018

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A calcium-dependent protein kinase regulates Plasmodium ookinete access to the midgut epithelial cell.

21 January 2018

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Plasmodium berghei calcium-dependent protein kinase 3 is required for ookinete gliding motility and mosquito midgut invasion

21 January 2018

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Protein kinases as drug targets in parasitic protozoa

21 January 2018

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21 January 2018

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Kinase selectivity profiling by inhibitor affinity chromatography

21 January 2018

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The purinome, a complex mix of drug and toxicity targets

21 January 2018

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Roscovitine targets, protein kinases and pyridoxal kinase

21 January 2018

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Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum.

21 January 2018

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Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

21 January 2018

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Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target

21 January 2018

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A role for coccidian cGMP-dependent protein kinase in motility and invasion

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Cyclin-dependent protein kinases as therapeutic drug targets for antimalarial drug development

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

21 January 2018

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Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K

21 January 2018

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The use of anticancer drugs in antiparasitic chemotherapy

21 January 2018

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The liver stage of Plasmodium berghei inhibits host cell apoptosis

21 January 2018

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Erythrocyte signal transduction pathways, their oxygenation dependence and functional significance

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Modulation of Ca2+-activated K+ channels of human erythrocytes by endogenous protein kinase C.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Differential effects of quercetin and resveratrol on Band 3 tyrosine phosphorylation signalling of red blood cells.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model

21 January 2018

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Cdk2 knockout mice are viable

21 January 2018

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Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

21 January 2018

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21 January 2018

Biological revelations

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.279

A genomic perspective of protein kinases in Plasmodium falciparum

21 January 2018

1 reference

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10.1517/14728222.11.3.279

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

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