(Q36734932)

16 August 2017

1 reference

title

The hERG potassium channel as a therapeutic target (English)

1 reference

16 August 2017

Harry J Witchel

1

1 reference

PubMed ID

17298291

16 August 2017

language of work or name

English

0 references

publication date

1 March 2007

1 reference

Expert Opinion on Therapeutic Targets

16 August 2017

1 reference

16 August 2017

11

1 reference

16 August 2017

321-336

1 reference

16 August 2017

3

1 reference

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels

16 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

A family of potassium channel genes related to eag in Drosophila and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

HERG, a human inward rectifier in the voltage-gated potassium channel family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Molecular and cellular mechanisms of cardiac arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

hERG potassium channels and cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Thorough QT/QTc not so thorough: removes torsadogenic predictors from the T-wave, incriminates safe drugs, and misses profibrillatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Psychotropic drugs, cardiac arrhythmia, and sudden death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

21 January 2018

The long Q-T syndrome

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Pharmacological treatment of atrial fibrillation: mechanisms of action and efficacy of class III drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Time course and voltage dependence of expressed HERG current compared with native "rapid" delayed rectifier K current during the cardiac ventricular action potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

X-ray structure of a voltage-dependent K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

The inward rectification mechanism of the HERG cardiac potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Biophysical properties of heteromultimeric erg K+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Determination of the subunit stoichiometry of a voltage-activated potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Electrophysiological characterization of an alternatively processed ERG K+ channel in mouse and human hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Cardiac IKr channels minimally comprise hERG 1a and 1b subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

A K+ channel splice variant common in human heart lacks a C-terminal domain required for expression of rapidly activating delayed rectifier current.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

A minK-HERG complex regulates the cardiac potassium current I(Kr)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

A common polymorphism associated with antibiotic-induced cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

HERG K+ channels: friend and foe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

A structural basis for drug-induced long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Physicochemical features of the HERG channel drug binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Alteration of HERG current profile during the cardiac ventricular action potential, following a pore mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Inhibition of HERG potassium channel current by the class 1a antiarrhythmic agent disopyramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Antiarrhythmic drugs for maintaining sinus rhythm after cardioversion of atrial fibrillation: a systematic review of randomized controlled trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Medical management of atrial fibrillation: state of the art.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

A comparison of rate control and rhythm control in patients with atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Functional and pharmacological properties of canine ERG potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Molecular determinants of HERG channel block.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

A radiolabeled peptide ligand of the hERG channel, [125I]-BeKm-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

BeKm-1 Is a HERG-Specific Toxin that Shares the Structure with ChTx but the Mechanism of Action with ErgTx1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Characterization of a hERG screen using the IonWorks HT: comparison to a hERG rubidium efflux screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Population patch clamp improves data consistency and success rates in the measurement of ionic currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Targeted therapy for short QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Short QT Syndrome: a familial cause of sudden death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Sudden death associated with short-QT syndrome linked to mutations in HERG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Short QT syndrome and atrial fibrillation caused by mutation in KCNH2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Modulation of I(Kr) inactivation by mutation N588K in KCNH2: a link to arrhythmogenesis in short QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

The N588K-HERG K+ channel mutation in the 'short QT syndrome': mechanism of gain-in-function determined at 37 degrees C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Congenital short QT syndrome and implantable cardioverter defibrillator treatment: inherent risk for inappropriate shock delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Short QT syndrome: pharmacological treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

HERG K+ channels activation during beta(1) integrin-mediated adhesion to fibronectin induces an up-regulation of alpha(v)beta(3) integrin in the preosteoclastic leukemia cell line FLG 29.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Signalling pathways that mediate skeletal muscle hypertrophy and atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Merg1a K+ channel induces skeletal muscle atrophy by activating the ubiquitin proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Sotalol: An important new antiarrhythmic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Electrophysiologic basis for the antiarrhythmic actions of sotalol and comparison with other agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Structural determinants of HERG channel block by clofilium and ibutilide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

High affinity HERG K(+) channel blockade by the antiarrhythmic agent dronedarone: resistance to mutations of the S6 residues Y652 and F656.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea].

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Mechanism of action of a novel human ether-a-go-go-related gene channel activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Thapsigargin selectively rescues the trafficking defective LQT2 channels G601S and F805C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Pharmacological rescue of human K(+) channel long-QT2 mutations: human ether-a-go-go-related gene rescue without block

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Researchers and regulators reflect on first gene therapy death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

In vitro and in vivo models for testing arrhythmogenesis in drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

QT prolongation in anaesthetized guinea-pigs: an experimental approach for preliminary screening of torsadogenicity of drugs and drug candidates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Medicinal chemistry of hERG optimizations: Highlights and hang-ups

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Pharmacogenetics and drug-induced arrhythmias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

Expression and Role of hERG Channels in Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.321

10.1517/14728222.11.3.321

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17298291