(Q36761837)

English

Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors.

scientific article published on 16 May 2008

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18487206%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18487206%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

5

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7 January 2020

author name string

Jonathan A Roberts

1

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7 January 2020

Helen R Digby

2

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7 January 2020

Madina Kara

3

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7 January 2020

Sam El Ajouz

4

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7 January 2020

Richard J Evans

6

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7 January 2020

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publication date

16 May 2008

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7 January 2020

number of pages

11

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inferred from page(s)

Journal of Biological Chemistry

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7 January 2020

283

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7 January 2020

29

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7 January 2020

20126-20136

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18487206%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Thr339-to-serine substitution in rat P2X2 receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys308.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Role of aromatic and charged ectodomain residues in the P2X(4) receptor functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Cysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Identification of an intersubunit cross-link between substituted cysteine residues located in the putative ATP binding site of the P2X1 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Molecular properties of P2X receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

A C-terminal lysine that controls human P2X4 receptor desensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Pathophysiology and therapeutic potential of purinergic signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

ATP signaling is crucial for communication from taste buds to gustatory nerves

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Non-canonical YXXGPhi endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Molecular determinants of the agonist binding domain of a P2X receptor channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Molecular properties of ATP-gated P2X receptor ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Molecular physiology of P2X receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Identification of a non-canonical tyrosine-based endocytic motif in an ionotropic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

P2X receptor trafficking in neurons is subunit specific.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Mutational analysis of the conserved cysteines of the rat P2X2 purinoceptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Amino acid residues involved in gating identified in the first membrane-spanning domain of the rat P2X(2) receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Identification of amino acid residues contributing to the pore of a P2X receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

An antagonist-insensitive P2X receptor expressed in epithelia and brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2459275

29 September 2017

Molecular dissection of purinergic P2X receptor channels.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800294200

21 January 2018

The role of positively charged amino acids in ATP recognition by human P2X(1) receptors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800294200

21 January 2018

A P2X purinoceptor cDNA conferring a novel pharmacological profile.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800294200

21 January 2018

ATP binding at human P2X1 receptors. Contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800294200

21 January 2018

Identification of Amino Acid Residues Contributing to the ATP-binding Site of a Purinergic P2X Receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M800294200

21 January 2018

A domain contributing to the ion channel of ATP-gated P2X2 receptors identified by the substituted cysteine accessibility method

1 reference

https://pubmed.ncbi.nlm.nih.gov/18487206

12 December 2020

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Identifiers

10.1074/JBC.M800294200

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18487206%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18487206%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18487206%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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