(Q36763477)

16 August 2017

1 reference

title

In vitro approaches to develop weight of evidence (WoE) and mode of action (MoA) discussions with positive in vitro genotoxicity results (English)

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16 August 2017

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Kirkland DJ

1

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16 August 2017

Aardema M

2

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16 August 2017

Banduhn N

3

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16 August 2017

Carmichael P

4

1 reference

16 August 2017

Fautz R

5

1 reference

16 August 2017

Meunier JR

6

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16 August 2017

Pfuhler S

7

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16 August 2017

16 March 2007

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16 August 2017

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16 August 2017

22

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16 August 2017

161-175

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16 August 2017

3

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Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity

16 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

A review of the genotoxicity of marketed pharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Aneuploidy in Drosophila, II. Further validation of the FIX and ZESTE genetic test systems employing female Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Concepts of threshold in mutagenesis and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Human biological relevance and the use of threshold-arguments in regulatory genotoxicity assessment: experience with pharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Semi-quantitative evaluation of genotoxic activity of chemical substances and evidence for a biological threshold of genotoxic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Threshold effects in genetic toxicity: perspective of chemicals regulation in Germany.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Thresholds in genotoxicity responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Interpretation of the biological relevance of genotoxicity test results: the importance of thresholds

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

DNA intercalative potential of marketed drugs testing positive in in vitro cytogenetics assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

The Salmonella/mammalian microsome mutagenicity test: comparison of human and rat livers as activating systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Advantage of the use of human liver S9 in the Ames test

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Genetically engineered V79 Chinese hamster cells metabolically activate the cytostatic drugs cyclophosphamide and ifosfamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

The use of genetically engineered V79 Chinese hamster cultures expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Micronucleus assays using cytochalasin-blocked MCL-5 cells, a proprietary human cell line expressing five human cytochromes P-450 and microsomal epoxide hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Studies on metabolism and toxicity of styrene: III. The effect of metabolic inactivation by rat-liver S9 on the mutagenicity of phenyloxirane toward Salmonella typhimurium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Characterization of p53 in Chinese hamster cell lines CHO-K1, CHO-WBL, and CHL: implications for genotoxicity testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

The mouse lymphoma L5178Y Tk+/- cell line is heterozygous for a codon 170 mutation in the p53 tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

The p53 status of Chinese hamster V79 cells frequently used for studies on DNA damage and DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Chromosome aberrations in Chinese hamster and human cells: a comparison using compounds with various genotoxicity profiles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Further debate of testing strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Oxidative stress in cell culture: an under-appreciated problem?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Factors affecting the ascorbate- and phenolic-dependent generation of hydrogen peroxide in Dulbecco's Modified Eagles Medium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Transgenic Chinese hamster V79 cell lines which exhibit variable levels of gpt mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Critical features of bacterial mutation assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Interactions of histidine-containing test substances and extraction methods with the Ames mutagenicity test

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Sodium azide mutagenesis in mammals: inability of mammalian cells to convert azide to a mutagenic intermediate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Kinetics and cofactor requirements for the nitroreductive metabolism of 1-nitropyrene and 3-nitrofluoranthene by rabbit liver aldehyde oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Genotoxicity assessment of the antiepileptic drug AMP397, an Ames-positive aromatic nitro compound.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

S9-mediated metabolism of 1-nitropyrene to a mutagen in Chinese hamster ovary cells by ring-oxidation under aerobic conditions and by nitroreduction under anaerobic conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Multiple mechanisms in hepatic microsomal azoreduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Reduction of azo dyes during in vitro percutaneous absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

The Mechanism of Action of Inhibitors of DNA Synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Detection of in vitro clastogens and spindle poisons by the mouse lymphoma assay using the microwell method: interim report of an international collaborative study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM Working Group on the in vitro micronucleus test. Gesellschaft für Umwelt-Mutations-forschung

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

SOS induction in Escherichia coli and Salmonella mutagenicity: a comparison using 330 compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Aphidicolin and bleomycin induced chromosome damage as biomarker of mutagen sensitivity: a twin study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Sodium fluoride-induced chromosome aberrations in different stages of the cell cycle: a proposed mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Inhibition of DNA polymerase-α and -β of calf thymus by 1-β-d-arabinofuranosylcytosine-5′-triphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Prophage induction by DNA topoisomerase II poisons and reactive-oxygen species: role of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

The VITOTOX test, an SOS bioluminescence Salmonella typhimurium test to measure genotoxicity kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Poly(ADP-ribose)polymerase-activity of chicken embryo cells exposed to nucleotoxic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Genotoxicity of 17 gyrase- and four mammalian topoisomerase II-poisons in prokaryotic and eukaryotic test systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Evaluation of the clastogenic, DNA intercalative, and topoisomerase II-interactive properties of bioflavonoids in Chinese hamster V79 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Inhibitors of topoisomerase II enzymes: a unique group of environmental mutagens and carcinogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Enhancement of bleomycin-induced micronucleus formation in V79 cells as a rapid and sensitive screen for non-covalent DNA-binding compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Clastogenic effects of two tyrosine kinase inhibitors, tyrphostin 23 and tyrphostin 46, on a transformed (CHO-K1) and on a primary embryonic chinese hamster cell line (CHE).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Mutagenesis and deoxyribonucleotide pool imbalance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

International Commission for Protection Against Environmental Mutagens and Carcinogens. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Inhibition of mitochondrial respiration by flavoskyrin, a toxic metabolite of Penicillium islandicum Sopp

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Cytotoxicity and genotoxicity of xenoclauxin and desacetyl duclauxin from Penicillium duclauxii (Delacroix).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Inability of chlorophenols to induce 6-thioguanine-resistant mutants in V79 Chinese hamster cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Experiments on the mechanism of action of tetrasodium 2 - methyl - 1 : 4- naphthohydroquinone diphosphate as a mitotic inhibitor and radiosensitiser, using the technique of tissue culture: relation between cytological effects and chemical constitut

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Assessment of mitochondrial membrane potential as an indicator of cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Genotoxicity study of CS (ortho-chlorobenzylidenemalononitrile) in Salmonella, Drosophila, and mice. Failure to detect mutagenic effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Discrimination between genotoxicity and cytotoxicity in the induction of DNA double-strand breaks in cells treated with etoposide, melphalan, cisplatin, potassium cyanide, Triton X-100, and gamma-irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Series: current issues in mutagenesis and carcinogenesis, No. 65. The genotoxicity and carcinogenicity of paracetamol: a regulatory (re)view

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Role of oxygen radicals in DNA damage and cancer incidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Experimental study of oxidative DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Chloroform, carbon tetrachloride and glutathione depletion induce secondary genotoxicity in liver cells via oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

The role of oxidative stress in the in vitro induction of micronuclei by pesticides in mouse lung fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Oxidative DNA damage in peripheral blood cells in type 2 diabetes mellitus: higher vulnerability of polymorphonuclear leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Detection of oxidative DNA damage in isolated marine bivalve hemocytes using the comet assay and formamidopyrimidine glycosylase (Fpg).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Role of cellular antioxidants in metal-induced damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Ricin-induced hepatic lipid peroxidation, glutathione depletion, and DNA single-strand breaks in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Chemical reactivity, cytotoxicity, and mutagenicity of chloropropanones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

The reactivity of selected acrylate esters toward glutathione and deoxyribonucleosides in vitro: structure-activity relationships.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Oxidative mechanisms in the toxicity of metal ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Dissociation of DDVP-induced DNA strand breaks from oxidative damage in isolated rat hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Mouse lymphoma L5178Y thymidine kinase locus assay of 50 compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Effect of dieldrin on the stability of lysosomes in the rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

The mutagenicity of sodium fluoride to L5178Y [wild-type and TK+/- (3.7.2c)] mouse lymphoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

N-chloropiperidine and calcium hypochlorite: possible examples of toxicity-dependent clastogenicity in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Analysis of chromosome segregation in cytokinesis-blocked human lymphocytes: non-disjunction is the prevalent damage resulting from low dose exposure to spindle poisons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Chromosomal aberration tests in vitro: problems with protocol design and interpretation of results.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Genotoxicity of 'gudakhu', a tobacco preparation. I. In mice in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Population doubling: a simple and more accurate estimation of cell growth suppression in the in vitro assay for chromosomal aberrations that reduces irrelevant positive results.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Hypothesis: some mutagens directly alter specific chromosomal proteins (DNA topoisomerase II and peripheral proteins) to produce chromosome stickiness, which causes chromosome aberrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Inducibility of chromosomal aberrations by metal compounds in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Induction of superoxide dismutase, chromosomal aberrations and sister-chromatid exchanges by paraquat in Chinese hamster fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Studies on the ability of hypotonic solutions to induce chromosomal aberrations in V 79 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Primary mutagenicity screening of food additives currently used in Japan

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

The genotoxicity of sodium saccharin and sodium chloride in relation to their cancer-promoting properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Vitamins, phytochemicals, diets, and their implementation in cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM006

21 January 2018

Identifiers

DOI

10.1093/MUTAGE/GEM006

1 reference

16 August 2017

1 reference