(Q36809477)

English

Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases

scientific article published on 4 April 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases (English)

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

author name string

Y Zhu

1

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

P J Casey

2

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

A P Kumar

3

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

S Pervaiz

4

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

publication date

4 April 2013

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Cell Death and Disease

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

e568

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy

1 reference

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29 September 2017

Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

1 reference

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29 September 2017

Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation

1 reference

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29 September 2017

Bax activation by Bim?

1 reference

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29 September 2017

Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Statins activate a mitochondria-operated pathway of apoptosis in breast tumor cells by a mechanism regulated by ErbB2 and dependent on the prenylation of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors

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29 September 2017

Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells

1 reference

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29 September 2017

Simvastatin induces apoptosis in human breast cancer cells: p53 and estrogen receptor independent pathway requiring signalling through JNK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Breast cancer growth prevention by statins

1 reference

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29 September 2017

Statins and cancer prevention

1 reference

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29 September 2017

RhoGDIs revisited: novel roles in Rho regulation

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29 September 2017

Mechanisms of statin-mediated inhibition of small G-protein function

1 reference

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29 September 2017

Simvastatin induces proliferation inhibition and apoptosis in C6 glioma cells via c-jun N-terminal kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis.

1 reference

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29 September 2017

Spatial and temporal control of signaling through lipid rafts

1 reference

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29 September 2017

Depletion of membrane cholesterol causes ligand-independent activation of Fas and apoptosis

1 reference

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29 September 2017

Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells

1 reference

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29 September 2017

Rho is involved in superoxide formation during phagocytosis of opsonized zymosans

1 reference

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29 September 2017

Potential antitumor effects of statins (Review).

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29 September 2017

p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

The statins as anticancer agents

1 reference

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29 September 2017

Current molecular models for NADPH oxidase regulation by Rac GTPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Rho GTPases and their effector proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Functions of lipid rafts in biological membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

The caveolae membrane system

1 reference

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29 September 2017

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Functional rafts in cell membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Isolation of integral membrane proteins by phase partitioning with Triton X-114.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Phase separation of integral membrane proteins in Triton X-114 solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Cell cycle-specific effects of lovastatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

29 September 2017

Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

27 June 2018

Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

27 June 2018

RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription.

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27 June 2018

Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase

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27 June 2018

Geranylgeranylation facilitates proteasomal degradation of rho G-proteins in human trabecular meshwork cells.

1 reference

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5 September 2018

Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

5 September 2018

LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors

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5 September 2018

Preparation of membrane rafts

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5 September 2018

RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3641326

5 September 2018

Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells

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5 September 2018

Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S).

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5 September 2018

Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis.

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5 September 2018

Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels

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5 September 2018

Sterol-independent regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in tumor cells

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5 September 2018

Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

1 reference

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5 September 2018

Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells.

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5 September 2018

Comparison of kinetic properties between two mammalian ras p21 GDP/GTP exchange proteins, ras guanine nucleotide-releasing factor and smg GDP dissociation stimulation.

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5 September 2018

Effect of Anthrax Toxin's Lethal Factor on Ion Channels Formed by the Protective Antigen

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21 January 2018

Apoptosis induced by hydrogen peroxide is mediated by decreased superoxide anion concentration and reduction of intracellular milieu

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/23559002

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho GTPases and their effector proteins

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2013.103

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/CDDIS.2013.103

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 August 2017

ResearchGate publication ID

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