(Q36840442)

16 August 2017

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title

Chemopreventive efficacy of silymarin in skin and prostate cancer (English)

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16 August 2017

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1

Gagan Deep

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16 August 2017

2

Rajesh Agarwal

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16 August 2017

language of work or name

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1 June 2007

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Integrative Cancer Therapies

16 August 2017

published in

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16 August 2017

volume

6

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16 August 2017

issue

2

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16 August 2017

page(s)

130-145

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Cancer chemoprevention with dietary phytochemicals

16 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Dietary flavonoids and cancer risk: evidence from human population studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silymarin: a review of its clinical properties in the management of hepatic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Anti-angiogenic effect of silymarin on colon cancer LoVo cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Chemopreventive effects of a flavonoid antioxidant silymarin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Dietary silymarin suppresses 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

The carcinogenic risks of modern tanning equipment: is UV-A safer than UV-B?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

UV-induced skin cancer in a hairless mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Relevance of animal models of photocarcinogenesis to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

UV light-induced cyclobutane pyrimidine dimers are mutagenic in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

The biology of the (6-4) photoproduct

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Oxidant, antioxidant status and photocarcinogenesis: the role of gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Flavonoid antioxidant silymarin and skin cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Inhibitory effect of silymarin, an anti-hepatotoxic flavonoid, on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

21 January 2018

Oxy-radicals and cancer

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Active Oxygen Species as Factors in Multistage Carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Mechanisms of lipid peroxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Tyrosine kinase inhibition: an approach to drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Natural flavonoids targeting deregulated cell cycle progression in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Multistage carcinogenesis in mouse skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Constitutive expression of 8-lipoxygenase in papillomas and clastogenic effects of lipoxygenase-derived arachidonic acid metabolites in keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors: suppression of skin tumor promotion by inhibition of prostaglandin H synthase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Mechanisms and preclinical efficacy of silibinin in preventing skin cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin decreases prostate-specific antigen with cell growth inhibition via G1 arrest, leading to differentiation of prostate carcinoma cells: implications for prostate cancer intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Antiproliferative and apoptotic effects of silibinin in rat prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Androgen receptor in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Inhibitory effect of silibinin on ligand binding to erbB1 and associated mitogenic signaling, growth, and DNA synthesis in advanced human prostate carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Selective inhibition of NF-kappaB activation by the flavonoid hepatoprotector silymarin in HepG2. Evidence for different activating pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silymarin inhibits TNF-alpha-induced expression of adhesion molecules in human umbilical vein endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Angiogenesis and tumor metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Milk thistle: is there a role for its use as an adjunct therapy in patients with cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Toward a core nutraceutical program for cancer management

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silymarin augments human cervical cancer HeLa cell apoptosis via P38/JNK MAPK pathways in serum-free medium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin efficacy against human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin inhibits UVB- and epidermal growth factor-induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-kappaB in mouse epidermal JB6 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Silibinin modulates UVB-induced apoptosis via mitochondrial proteins, caspases activation, and mitogen-activated protein kinase signaling in human epidermoid carcinoma A431 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Induction of human promyelocytic leukemia HL-60 cell differentiation into monocytes by silibinin: involvement of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Antitumour activity of the silybin-phosphatidylcholine complex, IdB 1016, against human ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Effect of silibinin on the growth and progression of primary lung tumors in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

Randomized, double-blind, placebo-controlled crossover study in men with prostate cancer and rising PSA: effectiveness of a dietary supplement

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1534735407301441

21 January 2018

Identifiers

DOI

10.1177/1534735407301441

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16 August 2017

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