(Q36864053)

16 August 2017

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title

Universal strategies in research and drug discovery based on protein-fragment complementation assays (English)

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16 August 2017

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1

Stephen W Michnick

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16 August 2017

Po Hien Ear

2

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16 August 2017

Emily N Manderson

series ordinal

3

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16 August 2017

Ingrid Remy

series ordinal

4

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16 August 2017

Eduard Stefan

series ordinal

5

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16 August 2017

1 July 2007

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Nature Reviews Drug Discovery

16 August 2017

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16 August 2017

6

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16 August 2017

569-582

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16 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrd2311

16 August 2017

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cites work

Drug discovery: a historical perspective

1 reference

Accessing genetic information with high-density DNA arrays.

31 March 2020

1 reference

How molecular profiling could revolutionize drug discovery

31 March 2020

1 reference

Drug target validation and identification of secondary drug target effects using DNA microarrays

31 March 2020

1 reference

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

31 March 2020

1 reference

Functional discovery via a compendium of expression profiles

31 March 2020

1 reference

Genomic profiling of drug sensitivities via induced haploinsufficiency.

31 March 2020

1 reference

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

31 March 2020

1 reference

Integrating genetic approaches into the discovery of anticancer drugs

31 March 2020

1 reference

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

31 March 2020

1 reference

Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays.

31 March 2020

1 reference

Detection of protein-protein interactions in plants using bimolecular fluorescence complementation

31 March 2020

1 reference

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

31 March 2020

1 reference

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

31 March 2020

1 reference

From molecular to modular cell biology

31 March 2020

1 reference

Global mapping of the yeast genetic interaction network

31 March 2020

1 reference

Functional and topological characterization of protein interaction networks.

31 March 2020

1 reference

Revealing modular organization in the yeast transcriptional network.

31 March 2020

1 reference

The identification of functional modules from the genomic association of genes

31 March 2020

1 reference

Modular organization of cellular networks

31 March 2020

1 reference

Interaction networks in yeast define and enumerate the signaling steps of the vertebrate aryl hydrocarbon receptor

31 March 2020

1 reference

Split ubiquitin as a sensor of protein interactions in vivo

31 March 2020

1 reference

Redesigned anti-human placental alkaline phosphatase single-chain Fv: soluble expression, characterization and in vivo tumour targeting

31 March 2020

1 reference

Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragments.

31 March 2020

1 reference

Detection of protein-protein interactions by protein fragment complementation strategies

31 March 2020

1 reference

Clonal selection and in vivo quantitation of protein interactions with protein-fragment complementation assays

31 March 2020

1 reference

Erythropoietin receptor activation by a ligand-induced conformation change

31 March 2020

1 reference

Visualization of biochemical networks in living cells

31 March 2020

1 reference

Beta-lactamase protein fragment complementation assays as in vivo and in vitro sensors of protein protein interactions

31 March 2020

1 reference

Time-lapse imaging of a dynamic phosphorylation-dependent protein-protein interaction in mammalian cells

31 March 2020

1 reference

Protein-protein interactions monitored in mammalian cells via complementation of beta -lactamase enzyme fragments

31 March 2020

1 reference

Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation

31 March 2020

1 reference

A cDNA library functional screening strategy based on fluorescent protein complementation assays to identify novel components of signaling pathways

31 March 2020

1 reference

Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt

31 March 2020

1 reference

PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3.

31 March 2020

1 reference

Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals

31 March 2020

1 reference

Locating a protein-protein interaction in living cells via split Renilla luciferase complementation

31 March 2020

1 reference

Monitoring Protein−Protein Interactions Using Split Synthetic Renilla Luciferase Protein-Fragment-Assisted Complementation

31 March 2020

1 reference

A highly sensitive protein-protein interaction assay based on Gaussia luciferase

31 March 2020

1 reference

Monitoring protein-protein interactions in intact eukaryotic cells by beta-galactosidase complementation

31 March 2020

1 reference

A fluorescent indicator for detecting protein-protein interactions in vivo based on protein splicing

31 March 2020

1 reference

An in vivo library-versus-library selection of optimized protein-protein interactions

31 March 2020

1 reference

Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism.

31 March 2020

1 reference

Capturing protein interactions in the secretory pathway of living cells

31 March 2020

1 reference

A heterodimeric coiled-coil peptide pair selected in vivo from a designed library-versus-library ensemble.

31 March 2020

1 reference

Massive sequence perturbation of a small protein.

31 March 2020

1 reference

The transition state of the ras binding domain of Raf is structurally polarized based on Phi-values but is energetically diffuse.

31 March 2020

1 reference

Massive sequence perturbation of the Raf ras binding domain reveals relationships between sequence conservation, secondary structure propensity, hydrophobic core organization and stability

31 March 2020

1 reference

Rapid selection of specific MAP kinase-binders from designed ankyrin repeat protein libraries

31 March 2020

1 reference

Direct Selection of Antibodies from Complex Libraries with the Protein Fragment Complementation Assay

31 March 2020

1 reference

Erythropoietin receptor and interleukin-2 receptor beta chain: a new receptor family

31 March 2020

1 reference

Expression cloning of a functional glycoprotein ligand for P-selectin

31 March 2020

1 reference

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

31 March 2020

1 reference

The art and design of genetic screens: mammalian culture cells

31 March 2020

1 reference

Signal transduction: signaling specificity- a complex affair

31 March 2020

1 reference

A comprehensive two-hybrid analysis to explore the yeast protein interactome

31 March 2020

1 reference

Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins

31 March 2020

1 reference

Progress and variations in two-hybrid and three-hybrid technologies

31 March 2020

1 reference

Protein interaction mapping in C. elegans using proteins involved in vulval development

31 March 2020

1 reference

Yeast forward and reverse 'n'-hybrid systems

31 March 2020

1 reference

A novel genetic system to detect protein-protein interactions

31 March 2020

1 reference

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

31 March 2020

1 reference

A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners

31 March 2020

1 reference

Identifying off-target effects and hidden phenotypes of drugs in human cells

31 March 2020

1 reference

Noninvasive imaging of protein-protein interactions in living subjects by using reporter protein complementation and reconstitution strategies

31 March 2020

1 reference

Molecular imaging of drug-modulated protein-protein interactions in living subjects

31 March 2020

1 reference

Molecular imaging of homodimeric protein-protein interactions in living subjects

31 March 2020

1 reference

Firefly luciferase enzyme fragment complementation for imaging in cells and living animals.

31 March 2020

1 reference

Finding function in novel targets: C. elegans as a model organism.

31 March 2020

1 reference

Combinatorial marking of cells and organelles with reconstituted fluorescent proteins

31 March 2020

1 reference

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

31 March 2020

1 reference

Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo

31 March 2020

1 reference

Ubiquitin-assisted dissection of protein transport across membranes.

31 March 2020

1 reference

A genetic system based on split-ubiquitin for the analysis of interactions between membrane proteins in vivo

31 March 2020

1 reference

A new screen for protein interactions reveals that the Saccharomyces cerevisiae high mobility group proteins Nhp6A/B are involved in the regulation of the GAL1 promoter

31 March 2020

1 reference

Mapping protein-protein interactions for the yeast ABC transporter Ycf1p by integrated split-ubiquitin membrane yeast two-hybrid analysis

31 March 2020

1 reference

Large-scale identification of yeast integral membrane protein interactions

31 March 2020

1 reference

The kinetics of formation of native ribonuclease during oxidation of the reduced polypeptide chain

31 March 2020

1 reference

Principles that govern the folding of protein chains

31 March 2020

1 reference

ON THE ENZYMIC ACTIVITY OF SUBTILISIN-MODIFIED RIBONUCLEASE

31 March 2020

1 reference

Creating new fluorescent probes for cell biology.

31 March 2020

1 reference

Probing minimal independent folding units in dihydrofolate reductase by molecular dissection

31 March 2020

1 reference

Dynamic visualization of expressed gene networks

31 March 2020

1 reference

Direct visualization of protein interactions in plant cells

31 March 2020

1 reference

Simultaneous visualization of multiple protein interactions in living cells using multicolor fluorescence complementation analysis

31 March 2020

1 reference

An improved mRFP1 adds red to bimolecular fluorescence complementation.

31 March 2020

1 reference

Proximal, selective, and dynamic interactions between integrin alphaIIbbeta3 and protein tyrosine kinases in living cells

31 March 2020

1 reference

Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes.

31 March 2020

1 reference

Visualization of protein interactions in living plant cells using bimolecular fluorescence complementation

31 March 2020

1 reference

Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells

31 March 2020

1 reference

Live cell imaging of Gs and the beta2-adrenergic receptor demonstrates that both alphas and beta1gamma7 internalize upon stimulation and exhibit similar trafficking patterns that differ from that of the beta2-adrenergic receptor

31 March 2020

1 reference

Novel fusion protein approach for efficient high-throughput screening of small molecule-mediating protein-protein interactions in cells and living animals

31 March 2020

1 reference

Binding and stability determinants of the PPARgamma nuclear receptor-coactivator interface as revealed by shotgun alanine scanning and in vivo selection

31 March 2020

1 reference

Enhanced catalytic efficiency of aminoglycoside phosphotransferase (3')-IIa achieved through protein fragmentation and reassembly

31 March 2020

1 reference

Regulation of Cre recombinase by ligand-induced complementation of inactive fragments

31 March 2020

1 reference

A bacterial two-hybrid system based on a reconstituted signal transduction pathway

31 March 2020

1 reference

Monitoring regulated protein-protein interactions using split TEV

31 March 2020

1 reference

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Analysis of G protein betagamma dimer formation in live cells using multicolor bimolecular fluorescence complementation demonstrates preferences of beta1 for particular gamma subunits

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD2311

1 reference

Dimensions Publication ID

16 August 2017

0 references

1 reference