(Q36867029)

English

The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview

scientific article published on 29 June 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

1 reference

Europe PubMed Central

The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview (English)

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

cognitive dysfunction

1 reference

based on heuristic

inferred from title

author name string

Jiankang Liu

1

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

publication date

29 June 2007

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Neurochemical Research

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

33

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

194-203

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Mitochondrial decay in aging

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9403-0

21 January 2018

The biologic clock: the mitochondria?

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9403-0

21 January 2018

Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9403-0

21 January 2018

Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9403-0

21 January 2018

Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9403-0

21 January 2018

Risk factors for Alzheimer's disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9403-0

21 January 2018

Neurotoxicity at the N-methyl-D-aspartate receptor in energy-compromised neurons. An hypothesis for cell death in aging and disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial free radical generation, oxidative stress, and aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: protective effect of alpha-lipoic acid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-lipoic acid: a metabolic antioxidant and potential redox modulator of transcription.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain synaptosomal aging: free radicals and membrane fluidity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of oxidized and reduced lipoic acid using high-performance liquid chromatography and coulometric detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective efficacy of alpha-lipoic acid on acetylcholinesterase activity in aged rat brain regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein oxidation and enzyme activity decline in old brown Norway rats are reduced by dietary restriction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidants, antioxidants, and the degenerative diseases of aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular and mitochondrial changes in glutamate-induced HT4 neuronal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-lipoic acid increases Na+K+ATPase activity and reduces lipofuscin accumulation in discrete brain regions of aged rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting cellular energy production in neurological disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by the metabolic antioxidant alpha-lipoic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

"Brain-specific" nutrients: a memory cure?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of AMP-activated protein kinase in mitochondrial biogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Timing and the control of variation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA-dependent superoxide production and neurotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial DNA modifies cognition in interaction with the nuclear genome and age in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developments of a water-maze procedure for studying spatial learning in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by thiols of the mitochondrial complexes from 4-hydroxy-2-nonenal

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein oxidation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory amino acid uptake and N-methyl-D-aspartate-mediated secretion in a neural cell line

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitotoxic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nutritional approaches to combat oxidative stress in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beneficial effects of alpha-lipoic acid plus vitamin E on neurological deficit, reactive gliosis and neuronal remodeling in the penumbra of the ischemic rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative damage and mitochondrial decay in aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress, aging, and brain oxidative damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-lipoic acid in liver metabolism and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of L-carnitine and DL-alpha-lipoic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Micronutrient deficiencies and cognitive functioning

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-lipoic acid as a biological antioxidant

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of alpha-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relationship to NMDA receptor deficits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of oxidative stress and antioxidants in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caffeine, carnitine and choline supplementation of rats decreases body fat and serum leptin concentration as does exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamin E and neurodegenerative disorders associated with oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate neurotoxicity and diseases of the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of gamma-linolenic acid-alpha-lipoic acid on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptors activate the arachidonic acid cascade system in striatal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of alpha-lipoic acid and its positively charged amide analogue

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in mitochondrial membrane fluidity by lipid peroxidation products

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress, caloric restriction, and aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-dopa- and dopamine-(R)-alpha-lipoic acid conjugates as multifunctional codrugs with antioxidant properties.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoic acid as a novel treatment for Alzheimer's disease and related dementias.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The free radical theory of aging matures

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of alpha lipoic acid on intracerebroventricular streptozotocin model of cognitive impairment in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dihydrolipoic acid maintains ubiquinone in the antioxidant active form by two-electron reduction of ubiquinone and one-electron reduction of ubisemiquinone

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis, pulse radiolysis, and in vitro radioprotection studies of melatoninolipoamide, a novel conjugate of melatonin and alpha-lipoic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and mitochondrial dysfunction in neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mitochondrial biogenesis in skeletal muscle by CaMK

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioenergetic approaches for neuroprotection in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effect of alpha-lipoic acid and its positively charged amide analogue on nitric oxide production in RAW 264.7 macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AMP-activated protein kinase: a key system mediating metabolic responses to exercise

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delaying the mitochondrial decay of aging-a metabolic tune-up.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nutritional cofactor treatment in mitochondrial disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of aging and acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the effect of α-lipoic acid and α-tocopherol supplementation on measures of oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17605107

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11064-007-9403-0

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

ResearchGate publication ID

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