(Q36870572)

16 August 2017

1 reference

title

Technology insight: therapeutic RNA interference--how far from the neurology clinic? (English)

1 reference

16 August 2017

1 reference

Pedro Gonzalez-Alegre

series ordinal

1

1 reference

PubMed ID

17611488

16 August 2017

Henry L Paulson

series ordinal

2

1 reference

16 August 2017

1 July 2007

1 reference

Nature Clinical Practice Neurology

16 August 2017

1 reference

16 August 2017

3

1 reference

16 August 2017

7

1 reference

16 August 2017

394-404

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

16 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

1 reference

7 January 2021

Therapeutic RNA interference for neurodegenerative diseases: From promise to progress

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Molecular medicine for the brain: silencing of disease genes with RNA interference

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Silencing neurodegenerative disease: bringing RNA interference to the clinic

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

MicroRNAs: genomics, biogenesis, mechanism, and function

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

RNase III enzymes and the initiation of gene silencing

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Transcription and processing of human microRNA precursors

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

microPrimer: the biogenesis and function of microRNA.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

MicroRNA biogenesis: coordinated cropping and dicing

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Mechanisms of gene silencing by double-stranded RNA

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

miRNAs on the move: miRNA biogenesis and the RNAi machinery

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Perspective: machines for RNAi

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

MicroRNA biogenesis: drosha can't cut it without a partner

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

RNA interference in neuroscience: progress and challenges

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

RNAi as a tool to study cell biology: building the genome-phenome bridge

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

The silent revolution: RNA interference as basic biology, research tool, and therapeutic

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Identification of hundreds of conserved and nonconserved human microRNAs

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Phylogenetic shadowing and computational identification of human microRNA genes

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

How do microRNAs regulate gene expression?

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

The neuronal microRNA system

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

MicroRNAs regulate brain morphogenesis in zebrafish

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

RNA and microRNAs in fragile X mental retardation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

RNAi therapeutics: a potential new class of pharmaceutical drugs

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

The prospect of silencing disease using RNA interference

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Strategies for silencing human disease using RNA interference

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Short interfering RNAs as a tool for cancer gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

RNA interference for antiviral therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Toward an understanding of polyglutamine neurodegeneration

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Polyglutamine disease and neuronal cell death.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Aberrant cellular behavior of mutant torsinA implicates nuclear envelope dysfunction in DYT1 dystonia.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Mislocalization to the nuclear envelope: an effect of the dystonia-causing torsinA mutation.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Allele-specific RNA interference for neurological disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Toward therapy for DYT1 dystonia: allele-specific silencing of mutant TorsinA

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Allele-specific silencing of dominant disease genes

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Designing siRNA that distinguish between genes that differ by a single nucleotide

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

The neurobiology of the tuberous sclerosis complex

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Ataxia and hereditary disorders

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Toward cell specificity in SCA1

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Transgenic Small Interfering RNA Halts Amyotrophic Lateral Sclerosis in a Mouse Model

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Silencing of human alpha-synuclein in vitro and in rat brain using lentiviral-mediated RNAi

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-beta peptide in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Viral vectors for gene delivery to the nervous system

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Delivering RNA interference to the mammalian brain.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Therapeutic potential of RNA interference for neurological disorders

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Retraction of synapses and dendritic spines induced by off-target effects of RNA interference.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

How cells respond to interferons

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Induction of an interferon response by RNAi vectors in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Determinants of interferon-stimulated gene induction by RNAi vectors

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Activation of the interferon system by short-interfering RNAs

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Lack of interferon response in animals to naked siRNAs

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

A computational study of off-target effects of RNA interference

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Functional siRNAs and miRNAs Exhibit Strand Bias

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Asymmetry in the assembly of the RNAi enzyme complex

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Progress in transcriptionally targeted and regulatable vectors for genetic therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0551

7 January 2021

Identifiers

DOI

10.1038/NCPNEURO0551

1 reference

16 August 2017

1 reference

PubMed ID

17611488