(Q36911359)

English

Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced Parkinsonism via activation of tyrosine kinase receptor signaling pathway

scientific article published on 16 August 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

1 reference

Europe PubMed Central

Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced Parkinsonism via activation of tyrosine kinase receptor signaling pathway (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Parkinson's disease

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

substantia nigra

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based on heuristic

inferred from title

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based on heuristic

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parkinsonian syndrome

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based on heuristic

inferred from title

Silvia A. Mandel

1

object named as

Silvia A Mandel

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

author name string

Yotam Sagi

2

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Tamar Amit

3

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

publication date

16 August 2007

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

Neurochemical Research

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Europe PubMed Central

PubMed publication ID

17 August 2017

32

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Europe PubMed Central

PubMed publication ID

17 August 2017

10

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

1694-1699

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

https://scigraph.springernature.com/pub.10.1007/s11064-007-9351-8

0 references

Neuroprotective agents for clinical trials in Parkinson's disease: a systematic assessment

1 reference

https://api.crossref.org/works/10.1007%2FS11064-007-9351-8

21 January 2018

The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implication of the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effect of rasagiline in a rodent model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of MPTP-induced neurotoxicity by AGN-1133 and AGN-1135, selective inhibitors of monoamine oxidase-B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by rasagiline: a new therapeutic approach to Parkinson's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus-mediated transduction with human glial cell line-derived neurotrophic factor gene prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopamine depletion in striatum of mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline Mesylate, a New Mao-B Inhibitor for the Treatment of Parkinson's Disease: A Double-Blind Study as Adjunctive Therapy to Levodopa

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measuring the rate of progression and estimating the preclinical period of Parkinson's disease with [18F]dopa PET.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology of rasagiline (N-propargyl-1R-aminoindan).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological inhibitors of glycogen synthase kinase 3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GDNF administration induces recovery of the nigrostriatal dopaminergic system both in young and aged parkinsonian mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multifunctional drugs with different CNS targets for neuropsychiatric disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effect of rasagiline, a selective monoamine oxidase-B inhibitor, against closed head injury in the mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies with rasagiline, a MAO-B inhibitor, in experimental focal ischemia in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline improves quality of life in patients with early Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotection by monoamine oxidase B inhibitors: a therapeutic strategy for Parkinson's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topographical distribution of [125I]-glial cell line-derived neurotrophic factor in unlesioned and MPTP-lesioned rhesus monkey brain following a bolus intraventricular injection

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of Parkinson's disease : what's on the horizon?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GSK-3beta inhibition/beta-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional recovery in parkinsonian monkeys treated with GDNF

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives in MAPK-dependent amyloid precursor protein processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17701352

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11064-007-9351-8

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 August 2017

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