(Q36188726)

PubMed publication ID

12 August 2017

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title

Neuroprotection by rasagiline: a new therapeutic approach to Parkinson's disease? (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741719&resulttype=core&format=json

12 May 2020

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1 reference

Fabio Blandini

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741719&resulttype=core&format=json

12 May 2020

publication date

1 January 2005

1 reference

PubMed publication ID

16007239

CNS Neuroscience & Therapeutics

12 August 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741719&resulttype=core&format=json

12 May 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741719&resulttype=core&format=json

12 May 2020

issue

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741719&resulttype=core&format=json

12 May 2020

page(s)

183-194

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741719&resulttype=core&format=json

The mitochondrial permeability transition: its molecular mechanism and role in reperfusion injury

12 May 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2005.TB00269.X

Clinical trials of neuroprotection for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2005.TB00269.X

Oxidative damage and cytogenetic analysis in leukocytes of Parkinson's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2005.TB00269.X

Deprenyl is metabolized to methamphetamine and amphetamine in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2005.TB00269.X

Clinical applications of MAO-inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2005.TB00269.X

A review of the mechanisms and role of monoamine oxidase inhibitors in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2005.TB00269.X

Neuroprotective effect of rasagiline, a selective monoamine oxidase-B inhibitor, against closed head injury in the mouse

21 January 2018

1 reference

12 December 2020

Dopaminergic neurons degenerate by apoptosis in Parkinson's disease.

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12 December 2020

Apoptotic signal transduction: emerging pathways

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12 December 2020

Rasagiline, a monoamine oxidase-B inhibitor, protects NGF-differentiated PC12 cells against oxygen-glucose deprivation

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12 December 2020

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.

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12 December 2020

Cell death mechanisms in Parkinson's disease

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12 December 2020

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12 December 2020

Functional changes of the basal ganglia circuitry in Parkinson's disease.

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12 December 2020

Mechanisms underlying hypoxia-induced neuronal apoptosis

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12 December 2020

Studies with rasagiline, a MAO-B inhibitor, in experimental focal ischemia in the rat

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12 December 2020

Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease

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12 December 2020

Levodopa motor complications in Parkinson's disease

1 reference

12 December 2020

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

1 reference

12 December 2020

Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B

1 reference

12 December 2020

Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022

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12 December 2020

Changes in cytokines and neurotrophins in Parkinson's disease

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12 December 2020

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12 December 2020

Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease?

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12 December 2020

Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.

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12 December 2020

Glutamatergic influences on the basal ganglia.

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12 December 2020

How protein kinase C activation protects nerve cells from oxidative stress-induced cell death.

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12 December 2020

Mitochondria: a target for myocardial protection.

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12 December 2020

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

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12 December 2020

Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022.

1 reference

12 December 2020

The anti-Parkinson drug rasagiline and its cholinesterase inhibitor derivatives exert neuroprotection unrelated to MAO inhibition in cell culture and in vivo

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12 December 2020

Causes of neuronal death in Parkinson's disease.

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12 December 2020

Pathogenesis of Parkinson's disease

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12 December 2020

Rasagiline Mesylate, a New Mao-B Inhibitor for the Treatment of Parkinson's Disease: A Double-Blind Study as Adjunctive Therapy to Levodopa

1 reference

12 December 2020

Rasagiline and its (S) enantiomer increase survival and prevent stroke in salt-loaded stroke-prone spontaneously hypertensive rats

1 reference

12 December 2020

Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: comparison of rasagiline (TVP 1012) with selegiline

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12 December 2020

Neuroprotective and neurotoxic effects of monoamine oxidase-B inhibitors and derived metabolites under ischemia in PC12 cells

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12 December 2020

Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate].

1 reference

12 December 2020

Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines

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12 December 2020

Morphological and biochemical aspects of apoptosis, oncosis and necrosis

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12 December 2020

Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes

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12 December 2020

Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan

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12 December 2020

A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study

1 reference

12 December 2020

Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, reserpine reversal, serotonergic and dopaminergic behaviours

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12 December 2020

Bcl-2 and Bax modulate adenine nucleotide translocase activity.

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12 December 2020

Oxidative stress in Parkinson's disease

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12 December 2020

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

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12 December 2020

Fine Structure and Biochemical Mechanisms Underlying Nigrostriatal Inclusions and Cell Death after Proteasome Inhibition

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12 December 2020

The Adenine Nucleotide Translocator: A New Potential Chemotherapeutic Target

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12 December 2020

The essentiality of Bcl-2, PKC and proteasome–ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline

1 reference

12 December 2020

N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor

1 reference

12 December 2020

Therapeutic applications of selective and non-selective inhibitors of monoamine oxidase A and B that do not cause significant tyramine potentiation

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12 December 2020

Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline

1 reference

12 December 2020

Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide

1 reference

12 December 2020

A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease

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12 December 2020

Neuroprotective effect of rasagiline in a rodent model of Parkinson's disease

1 reference

12 December 2020

Regulation of protein kinase C by the anti-Parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo

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12 December 2020

Mechanism of neurodegenerative disease: role of the ubiquitin proteasome system

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12 December 2020

Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

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12 December 2020

Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members

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12 December 2020

Modifications of apoptosis-related protein levels in lymphocytes of patients with Parkinson's disease. The effect of dopaminergic treatment

1 reference

12 December 2020

Double-blind, randomized, controlled trial of rasagiline as monotherapy in early Parkinson's disease patients

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12 December 2020

Application of proteasomal inhibitors to mouse sympathetic neurons activates the intrinsic apoptotic pathway

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12 December 2020

Rasagiline alone and in combination with riluzole prolongs survival in an ALS mouse model

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12 December 2020

Inhibition of proteasome activity sensitizes dopamine neurons to protein alterations and oxidative stress

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12 December 2020

Tolerability, safety, pharmacodynamics, and pharmacokinetics of rasagiline: a potent, selective, and irreversible monoamine oxidase type B inhibitor

1 reference

12 December 2020

A randomized placebo-controlled trial of rasagiline in levodopa-treated patients with Parkinson disease and motor fluctuations: the PRESTO study

1 reference

12 December 2020

Neuroprotective effect of rasagiline, a monoamine oxidase-B inhibitor, on spontaneous cell degeneration in a rat model

1 reference

12 December 2020

Rasagiline as an adjunct to levodopa in patients with Parkinson's disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallel-group trial

1 reference

12 December 2020

DATATOP: a multicenter controlled clinical trial in early Parkinson's disease. Parkinson Study Group

1 reference

12 December 2020

The pharmacology of the parkinsonian syndrome producing neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and structurally related compounds

1 reference

12 December 2020

Prevention of MPTP-induced neurotoxicity by AGN-1133 and AGN-1135, selective inhibitors of monoamine oxidase-B.

1 reference

12 December 2020

1 reference

12 December 2020

Glutamate-induced apoptosis results in a loss of striatal neurons in the parkinsonian rat.

1 reference

12 December 2020

Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease

1 reference

12 December 2020

(-)-Deprenyl alters the survival of adult murine facial motoneurons after axotomy: increases in vulnerable C57BL strain but decreases in motor neuron degeneration mutants

1 reference

12 December 2020

Glutamate and Parkinson's disease

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12 December 2020

Histochemical detection of apoptosis in Parkinson's disease.

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12 December 2020

Neuropathology of Parkinson's disease

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12 December 2020

Effect of long-term treatment with selective monoamine oxidase A and B inhibitors on dopamine release from rat striatum in vivo.

1 reference

12 December 2020

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1 reference

12 December 2020

Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons.

1 reference

12 December 2020

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1 reference

12 December 2020

Upregulation of the anti-apoptotic protein Bcl-2 may be an early event in neurodegeneration: studies on Parkinson's and incidental Lewy body disease

1 reference

12 December 2020

1 reference

12 December 2020

Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders

1 reference

12 December 2020

Oxidative mechanisms in nigral cell death in Parkinson's disease.

1 reference

12 December 2020

Secondary excitotoxicity contributes to dopamine-induced apoptosis of dopaminergic neuronal cultures

1 reference

12 December 2020

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1 reference

12 December 2020

Programmed cell death: does it play a role in Parkinson's disease?

1 reference

12 December 2020

A revolution in apoptosis: from a nucleocentric to a mitochondriocentric perspective

1 reference

12 December 2020

Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations. Nomecomt Study Group

1 reference

12 December 2020

Caspase-3-like proteases and 6-hydroxydopamine induced neuronal cell death.

1 reference

12 December 2020

10.1111/J.1527-3458.2005.TB00269.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741719&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741719&resulttype=core&format=json

12 May 2020

PubMed publication ID

16007239

1 reference