(Q36928990)

English

Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion

scientific article published on 29 April 2013

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29 February 2020

Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion (English)

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29 February 2020

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Poul Henning Jensen

6

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29 February 2020

Frederik Vilhardt

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29 February 2020

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Patrick Ejlerskov

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29 February 2020

Izabela Rasmussen

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29 February 2020

Troels Tolstrup Nielsen

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29 February 2020

Ann-Louise Bergström

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29 February 2020

Yumi Tohyama

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29 April 2013

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29 February 2020

Journal of Biological Chemistry

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29 February 2020

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29 February 2020

17313-17335

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29 February 2020

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11 June 2022

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Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

1 reference

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29 September 2017

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

1 reference

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29 September 2017

Mechanism of evenness interrupted (Evi)-exosome release at synaptic boutons

1 reference

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29 September 2017

The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.

1 reference

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29 September 2017

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

1 reference

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29 September 2017

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

1 reference

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29 September 2017

α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

1 reference

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29 September 2017

Pathogenic lysosomal depletion in Parkinson's disease

1 reference

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29 September 2017

Overview of macroautophagy regulation in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Lysosomal degradation of alpha-synuclein in vivo.

1 reference

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29 September 2017

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Unconventional secretion of Acb1 is mediated by autophagosomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Rab27a and Rab27b control different steps of the exosome secretion pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless

1 reference

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29 September 2017

Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Autophagy and multivesicular bodies: two closely related partners

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

1 reference

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29 September 2017

The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Autophagosome formation: core machinery and adaptations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3682534

29 September 2017

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

1 reference

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29 September 2017

MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway.

1 reference

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29 September 2017

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

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29 September 2017

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

1 reference

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29 September 2017

Loss of autophagy in the central nervous system causes neurodegeneration in mice

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29 September 2017

Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

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29 September 2017

p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies

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29 September 2017

Role for Rab7 in maturation of late autophagic vacuoles

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29 September 2017

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

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29 September 2017

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

1 reference

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29 September 2017

TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation

1 reference

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29 September 2017

Antisense downregulation of mutant huntingtin in a cell model.

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29 September 2017

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29 September 2017

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29 September 2017

Late endosome motility depends on lipids via the small GTPase Rab7.

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

The autophagic and endocytic pathways converge at the nascent autophagic vacuoles

1 reference

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29 September 2017

Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

1 reference

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27 June 2018

Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein.

1 reference

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27 June 2018

Characterization of the Rab8-specific membrane traffic route linked to protrusion formation

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27 June 2018

Quantitative measurement of mast cell degranulation using a novel flow cytometric annexin-V binding assay

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27 June 2018

Rab27a negatively regulates phagocytosis by prolongation of the actin-coating stage around phagosomes

1 reference

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4 September 2018

Autophagy: a broad role in unconventional protein secretion?

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4 September 2018

The expression of tubulin polymerization promoting protein TPPP/p25alpha is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress

1 reference

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4 September 2018

The Rab8 GTPase regulates apical protein localization in intestinal cells

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4 September 2018

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

1 reference

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4 September 2018

Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions

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4 September 2018

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

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4 September 2018

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

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4 September 2018

The origin of the autophagosomal membrane

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21 January 2018

Selective autophagy: ubiquitin-mediated recognition and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/23629650

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.401174

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Europe PubMed Central

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29 February 2020

1 reference

Europe PubMed Central

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29 February 2020

1 reference

Europe PubMed Central

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29 February 2020

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