(Q40641130)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12797118%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

title

Antisense downregulation of mutant huntingtin in a cell model (English)

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4 November 2019

3

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4 November 2019

Lis Frydenreich Hasholt

1

object named as

Lis Hasholt

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4 November 2019

4

Christine Nellemann

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4 November 2019

author name string

Kathrine Abell

2

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4 November 2019

Kirsten Fenger

5

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4 November 2019

Sven Asger Sørensen

6

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4 November 2019

publication date

1 June 2003

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4 November 2019

published in

Journal of Gene Medicine

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4 November 2019

volume

5

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4 November 2019

issue

6

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4 November 2019

page(s)

528-538

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

4 November 2019

cites work

1 reference

Widespread expression of Huntington's disease gene (IT15) protein product

21 January 2018

1 reference

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

21 January 2018

1 reference

Protein fate in neurodegenerative proteinopathies: polyglutamine diseases join the (mis)fold

21 January 2018

1 reference

Lessons from animal models of Huntington's disease

21 January 2018

1 reference

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

21 January 2018

1 reference

A cellular model that recapitulates major pathogenic steps of Huntington's disease

21 January 2018

1 reference

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

21 January 2018

1 reference

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

21 January 2018

1 reference

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

21 January 2018

1 reference

Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease

21 January 2018

1 reference

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

21 January 2018

1 reference

Huntington's disease: translating a CAG repeat into a pathogenic mechanism

21 January 2018

1 reference

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

1 reference

Therapeutic strategies for Huntington's disease based on a molecular understanding of the disorder.

21 January 2018

1 reference

Antisense gene therapy for neurodegenerative disease?

21 January 2018

1 reference

Inhibition of Huntington synthesis by antisense oligodeoxynucleotides

21 January 2018

1 reference

Sequence-specific cleavage of Huntingtin mRNA by catalytic DNA.

21 January 2018

1 reference

Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro

21 January 2018

1 reference

Antisense therapy in oncology: new hope for an old idea?

21 January 2018

1 reference

Sensible use of antisense: how to use oligonucleotides as research tools

21 January 2018

1 reference

Mechanism of oligonucleotide release from cationic liposomes

21 January 2018

1 reference

Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix

21 January 2018

1 reference

Inhibition of high affinity basic fibroblast growth factor binding by oligonucleotides

21 January 2018

1 reference

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

21 January 2018

1 reference

The HD mutation causes progressive lethal neurological disease in mice expressing reduced levels of huntingtin.

21 January 2018

1 reference

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

21 January 2018

1 reference

Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening

21 January 2018

1 reference

Ubiquitin, cellular inclusions and their role in neurodegeneration

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/JGM.378

1 reference

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4 November 2019

1 reference