(Q36942517)

17 August 2017

1 reference

title

B-cell self-tolerance in humans (English)

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17 August 2017

author

Michel C. Nussenzweig

series ordinal

2

object named as

Michel C Nussenzweig

1 reference

17 August 2017

Hedda Wardemann

1

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17 August 2017

publication date

1 January 2007

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17 August 2017

language of work

Advances in Immunology

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17 August 2017

volume

95

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17 August 2017

page(s)

83-110

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B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production

17 August 2017

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Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus

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BAFF selectively enhances the survival of plasmablasts generated from human memory B cells.

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Type I interferon in systemic lupus erythematosus and other autoimmune diseases

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7 January 2021

BAFF mediates survival of peripheral immature B lymphocytes

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7 January 2021

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

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Maturation of the immune response in germinal centers

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Maintenance of serological memory by polyclonal activation of human memory B cells.

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A complete immunoglobulin gene is created by somatic recombination

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Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human

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Regulatory mechanisms that determine the development and function of plasma cells

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Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: relationships with B cell depletion, circulating antibodies, and clinical relapse

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Peripheral B-cell maturation: the intersection of selection and homeostasis

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7 January 2021

The complement system in regulation of adaptive immunity

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7 January 2021

Transitional B cells are the target of negative selection in the B cell compartment

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7 January 2021

Peripheral development of B cells in mouse and man.

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7 January 2021

Contribution of Receptor Editing to the Antibody Repertoire

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Transitional B cells: step by step towards immune competence

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Molecular basis of immunoglobulin variable region gene usage in systemic autoimmunity

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7 January 2021

Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells

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7 January 2021

Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

The regulation of lupus-associated autoantibodies: immunoglobulin transgenic models

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow

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7 January 2021

Receptor editing: an approach by autoreactive B cells to escape tolerance

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7 January 2021

Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain gene loci

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Most peripheral B cells in mice are ligand selected

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Reassessing the function of immune-complex retention by follicular dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

1 reference

7 January 2021

CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

BCR ligation induces receptor editing in IgM+IgD- bone marrow B cells in vitro

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Intraclonal generation of antibody mutants in germinal centres

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

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7 January 2021

Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Autoreactive B cells in the marginal zone that express dual receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Generation of peripheral B cells occurs via two spatially and temporally distinct pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

What do mouse models teach us about human SLE?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Development and selection of marginal zone B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Viral superantigen drives extrafollicular and follicular B cell differentiation leading to virus-specific antibody production

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

1 reference

7 January 2021

Maintenance of serum antibody levels

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Toll-like receptors in systemic autoimmune disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Antibody regulation of B cell development

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies

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7 January 2021

B cell tolerance--how to make it and how to break it.

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7 January 2021

Challenges in bringing the bench to bedside in drug development for SLE.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Positive and negative selection during B lymphocyte development

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Bruton's tyrosine kinase is essential for human B cell tolerance

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Fcgamma receptors: old friends and new family members

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Visualization of the genesis and fate of isotype-switched B cells during a primary immune response

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

BAFF overexpression is associated with autoantibody production in autoimmune diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

High affinity germinal center B cells are actively selected into the plasma cell compartment.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Light chain replacement: a new model for antibody gene rearrangement

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https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

OCA-B integrates B cell antigen receptor-, CD40L- and IL 4-mediated signals for the germinal center pathway of B cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to Activation-Induced Cytidine Deaminase deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Competence and competition: the challenge of becoming a long-lived plasma cell

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Clonal selection and learning in the antibody system

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

1 reference

7 January 2021

Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Initiation and processing of signals from the B cell antigen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Receptor editing occurs frequently during normal B cell development.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Predictive value of autoantibodies for activity of systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Impaired early B cell tolerance in patients with rheumatoid arthritis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

B cell receptor-induced apoptosis in primary transitional murine B cells: signaling requirements and modulation by T cell help

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

B-cell-specif ic coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

In vivo imaging of germinal centres reveals a dynamic open structure

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Role of BCR affinity in T cell dependent antibody responses in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Antigen-induced B-cell death and elimination during germinal-centre immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Autoimmunity versus horror autotoxicus: the struggle for recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

A uniform deleting element mediates the loss of kappa genes in human B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

The splenic marginal zone in humans and rodents: an enigmatic compartment and its inhabitants

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

BlySfulness does not equal blissfulness in systemic lupus erythematosus: a therapeutic role for BLyS antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Autoantibodies and autoimmunity: a three-decade perspective. A tribute to Henry G. Kunkel

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Identification of functional human splenic memory B cells by expression of CD148 and CD27.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

BAFF, APRIL and human B cell disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Regulation of peripheral B cell maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Receptor editing in self-reactive bone marrow B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Autoreactivity in human IgG+ memory B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Somatic generation of antibody diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

A checkpoint for autoreactivity in human IgM+ memory B cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

The scope of receptor editing and its association with autoimmunity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Delineating the genetic basis of systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Predominant autoantibody production by early human B cell precursors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Human autoantibody silencing by immunoglobulin light chains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Rearrangement of genetic information may produce immunoglobulin diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

A bird's eye view on human B cells.

1 reference

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7 January 2021

CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Splenic marginal zone B cells in humans: where do they mutate their Ig receptor?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

The evolution of human anti-double-stranded DNA autoantibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

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7 January 2021

Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

FcγRIIb controls bone marrow plasma cell persistence and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Defective B cell tolerance checkpoints in systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

Persistent expression of autoantibodies in SLE patients in remission

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

1 reference

7 January 2021

The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2807%2995003-8

7 January 2021

10.1016/S0065-2776(07)95003-8

Identifiers

DOI

1 reference

17 August 2017

1 reference