(Q36960486)

17 August 2017

1 reference

title

mRNA stability and cancer: an emerging link? (English)

1 reference

17 August 2017

Don Benjamin

1

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17 August 2017

Christoph Moroni

series ordinal

2

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17 August 2017

language of work or name

English

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publication date

1 October 2007

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Expert Opinion on Biological Therapy

17 August 2017

published in

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17 August 2017

volume

7

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17 August 2017

issue

10

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17 August 2017

page(s)

1515-1529

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The highways and byways of mRNA decay

17 August 2017

cites work

1 reference

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P bodies and the control of mRNA translation and degradation

21 January 2018

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Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation.

21 January 2018

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Global analysis of stress-regulated mRNA turnover by using cDNA arrays

21 January 2018

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Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability

21 January 2018

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AU-rich elements: characterization and importance in mRNA degradation

21 January 2018

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Functional characterization of a non-AUUUA AU-rich element from the c-jun proto-oncogene mRNA: evidence for a novel class of AU-rich elements

21 January 2018

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Modulation of the fate of cytoplasmic mRNA by AU-rich elements: key sequence features controlling mRNA deadenylation and decay

21 January 2018

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ARED 2.0: an update of AU-rich element mRNA database.

21 January 2018

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ARED 3.0: the large and diverse AU-rich transcriptome.

21 January 2018

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Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

A Constitutive Decay Element Promotes Tumor Necrosis Factor Alpha mRNA Degradation via an AU-Rich Element-Independent Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Destabilization of interleukin-6 mRNA requires a putative RNA stem-loop structure, an AU-rich element, and the RNA-binding protein AUF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Involvement of microRNA in AU-rich element-mediated mRNA instability

21 January 2018

1 reference

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A hairpin-like structure within an AU-rich mRNA-destabilizing element regulates trans-factor binding selectivity and mRNA decay kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Control of c-myc mRNA half-life in vitro by a protein capable of binding to a coding region stability determinant

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Purification and characterization of a polysome-associated endoribonuclease that degrades c-myc mRNA in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

CRD-BP shields c-myc and MDR-1 RNA from endonucleolytic attack by a mammalian endoribonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Rapid cytoplasmic turnover of c-myc mRNA: requirement of the 3' untranslated sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Selective degradation of AU-rich mRNAs promoted by the p37 AUF1 protein isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

AU binding proteins recruit the exosome to degrade ARE-containing mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

c-Jun ARE targets mRNA deadenylation by an EDEN-BP (embryo deadenylation element-binding protein)-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Hu proteins regulate polyadenylation by blocking sites containing U-rich sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

mRNA openers and closers: modulating AU-rich element-controlled mRNA stability by a molecular switch in mRNA secondary structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

c-Src activates endonuclease-mediated mRNA decay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Decapping the message: a beginning or an end.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Reconstitution, activities, and structure of the eukaryotic RNA exosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

ARE-mRNA degradation requires the 5'-3' decay pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

A+U-rich instability elements differentially activate 5'-3' and 3'-5' mRNA decay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Relief of microRNA-mediated translational repression in human cells subjected to stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Modulation of mRNA stability as a novel therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Phosphorylation of p40AUF1 regulates binding to A + U-rich mRNA-destabilizing elements and protein-induced changes in ribonucleoprotein structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Control of mRNA decay by heat shock-ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3' untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

The role of cytokine mRNA stability in the pathogenesis of autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5' element and c-fos 3' sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Determinants that contribute to cytoplasmic stability of human c-fos and beta-globin mRNAs are located at several sites in each mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Correlation of amplification and overexpression of the c-myc oncogene in high-grade breast cancer: FISH, in situ hybridisation and immunohistochemical analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Complex translocation disrupts c-myc regulation in a human plasma cell myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Healthy mice with an altered c-myc gene: role of the 3' untranslated region revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Redundant cyclin overexpression and gene amplification in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Characterization of a candidate bcl-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

HuR regulates p21 mRNA stabilization by UV light

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

MAP kinases and hypoxia in the control of VEGF expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Prognostic significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in human gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Identification of nucleolin as an AU-rich element binding protein involved in bcl-2 mRNA stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Interleukin-3 mRNA stabilization by a trans-acting mechanism in autocrine tumors lacking interleukin-3 gene rearrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

c-jun N-terminal kinase is involved in AUUUA-mediated interleukin-3 mRNA turnover in mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Tumor suppression involves down-regulation of interleukin 3 expression in hybrids between autocrine mastocytoma and interleukin 3-dependent parental mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

A novel mechanism of tumor suppression by destabilizing AU-rich growth factor mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

The Wnt/beta-catenin-->Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

A transcriptional response to Wnt protein in human embryonic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

A global expression-based analysis of the consequences of the t(4;14) translocation in myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

TIS11D is a candidate pro-apoptotic p53 target gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Stabilization of cyclin D1 mRNA via the phosphatidylinositol 3-kinase pathway in MCF-7 human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Translational repression of human matrix metalloproteinases-13 by an alternatively spliced form of T-cell-restricted intracellular antigen-related protein (TIAR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Increased interleukin-10 mRNA stability in melanoma cells is associated with decreased levels of A + U-rich element binding factor AUF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

A "liaison dangereuse" between AUF1/hnRNPD and the oncogenic tyrosine kinase NPM-ALK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Creation of human tumour cells with defined genetic elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Coordinate stabilization of growth-regulatory transcripts in T cell malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Patterns of coordinate down-regulation of ARE-containing transcripts following immune cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Genome-wide analysis of mRNA decay in resting and activated primary human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

A module of negative feedback regulators defines growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

microRNAs as oncogenes and tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

mRNA stability control: a clandestine force in normal and malignant hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Stabilization of Urokinase and Urokinase Receptor mRNAs by HuR Is Linked to Its Cytoplasmic Accumulation Induced by Activated Mitogen-Activated Protein Kinase-Activated Protein Kinase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Deregulated c-fos expression interferes with normal bone development in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

Cyclosporin A inhibits growth of autocrine tumour cell lines by destabilizing interleukin-3 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.7.10.1515

10.1517/14712598.7.10.1515

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference