(Q36969182)

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The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins

scientific article published on September 2007

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scholarly article

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Europe PubMed Central

PMC publication ID

17 August 2017

3 references

Europe PubMed Central

24 November 2020

25 November 2020

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

1 reference

based on heuristic

inferred from title

multigene family

1 reference

24 November 2020

1 reference

25 November 2020

research impact

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based on heuristic

inferred from title

object named as

Wen Hwa Lee

3

0 references

Susanne Müller

object named as

Susanne Müller

5

0 references

object named as

Opher Gileadi

1

0 references

object named as

Stefan Knapp

2

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author name string

Brian D Marsden

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Frank H Niesen

6

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Kathryn L Kavanagh

7

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Linda J Ball

8

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Frank von Delft

9

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Declan A Doyle

10

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Udo C T Oppermann

11

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Michael Sundström

12

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

publication date

1 September 2007

3 references

Europe PubMed Central

PMC publication ID

17 August 2017

24 November 2020

25 November 2020

Journal of Structural and Functional Genomics

3 references

Europe PubMed Central

PMC publication ID

17 August 2017

24 November 2020

25 November 2020

8

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

2-3

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

107-119

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

https://scigraph.springernature.com/pub.10.1007/s10969-007-9027-2

0 references

The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs

1 reference

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29 September 2017

Structure and regulation of the human Nek2 centrosomal kinase

1 reference

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29 September 2017

A stress response pathway involving sirtuins, forkheads and 14-3-3 proteins

1 reference

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29 September 2017

Structural basis for protein-protein interactions in the 14-3-3 protein family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity

1 reference

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29 September 2017

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

1 reference

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29 September 2017

Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?

1 reference

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29 September 2017

Solution NMR in structural genomics

1 reference

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29 September 2017

New paradigms in anticancer therapy: targeting multiple signaling pathways with kinase inhibitors.

1 reference

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29 September 2017

14-3-3 proteins in cell cycle regulation

1 reference

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29 September 2017

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

1 reference

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29 September 2017

Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase

1 reference

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29 September 2017

The impact of structural genomics: expectations and outcomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Disseminating structural genomics data to the public: from a data dump to an animated story

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

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Regulation of drug transporters by PDZ adaptor proteins and nuclear receptors

1 reference

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29 September 2017

Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase

1 reference

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29 September 2017

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease

1 reference

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29 September 2017

Inhibition of 11beta-HSD1 as a novel treatment for the metabolic syndrome: do glucocorticoids play a role?

1 reference

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29 September 2017

Role of 14-3-3 proteins in eukaryotic signaling and development

1 reference

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29 September 2017

Kinomics: characterizing the therapeutically validated kinase space.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

A structural basis for 14-3-3sigma functional specificity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Coot: model-building tools for molecular graphics

1 reference

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29 September 2017

PDZ domain proteins of synapses

1 reference

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29 September 2017

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Protein kinase inhibitors: insights into drug design from structure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Kinomics-structural biology and chemogenomics of kinase inhibitors and targets

1 reference

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29 September 2017

11beta-hydroxysteroid dehydrogenase type 1 as a novel therapeutic target in metabolic and neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Structural basis for the autoinhibition of c-Abl tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

The protein kinase complement of the human genome

1 reference

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29 September 2017

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

1 reference

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29 September 2017

The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports--principles and applications

1 reference

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29 September 2017

Protein kinases--the major drug targets of the twenty-first century?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Fatty acid oxidation disorders

1 reference

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29 September 2017

High-density miniaturized thermal shift assays as a general strategy for drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Solution structure of a Nedd4 WW domain-ENaC peptide complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Inborn errors of mitochondrial fatty acid oxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

Validation of protein crystal structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2140095

29 September 2017

14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove

1 reference

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29 September 2017

The structural basis for 14-3-3:phosphopeptide binding specificity

1 reference

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29 September 2017

PDZ domain of neuronal nitric oxide synthase recognizes novel C-terminal peptide sequences

1 reference

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29 September 2017

Recognition of unique carboxyl-terminal motifs by distinct PDZ domains

1 reference

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29 September 2017

Crystal structure of a PDZ domain

1 reference

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29 September 2017

Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ

1 reference

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29 September 2017

Crystal structure of the zeta isoform of the 14-3-3 protein

1 reference

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29 September 2017

Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways

1 reference

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29 September 2017

14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking

1 reference

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Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy.

1 reference

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4 September 2018

Screening and optimization strategies for macromolecular crystal growth

1 reference

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4 September 2018

The structure and dynamics of tandem WW domains in a negative regulator of notch signaling, Suppressor of deltex

1 reference

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4 September 2018

pH and temperature-induced molten globule-like denatured states of equinatoxin II: a study by UV-melting, DSC, far- and near-UV CD spectroscopy, and ANS fluorescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/17932789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of 11 beta-hydroxysteroid dehydrogenase in central obesity and osteoporosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17932789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S10969-007-9027-2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

ResearchGate publication ID

0 references

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