(Q36999076)

17 August 2017

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title

Organ protection by hypoxia and hypoxia-inducible factors (English)

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17 August 2017

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6

Kai-Uwe Eckardt

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17 August 2017

Wanja M Bernhardt

1

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17 August 2017

Christina Warnecke

2

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17 August 2017

Carsten Willam

3

1 reference

17 August 2017

Tetsuhiro Tanaka

4

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17 August 2017

Michael S Wiesener

5

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17 August 2017

language of work or name

English

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publication date

1 January 2007

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17 August 2017

published in

Methods in Enzymology

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17 August 2017

volume

435

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17 August 2017

page(s)

221-245

1 reference

Physiological activation of hypoxia inducible factor-1 in human skeletal muscle

17 August 2017

cites work

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7 January 2021

Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors

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7 January 2021

An essential role for p300/CBP in the cellular response to hypoxia

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7 January 2021

Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues

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7 January 2021

Erythropoietin regulates endothelial progenitor cells

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7 January 2021

Erythropoietin mimics ischemic preconditioning

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7 January 2021

Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain

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7 January 2021

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

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7 January 2021

Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance.

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7 January 2021

Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure

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7 January 2021

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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7 January 2021

Gene transfer-induced local heme oxygenase-1 overexpression protects rat kidney transplants from ischemia/reperfusion injury

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7 January 2021

Preconditioning: a paradigm shift in the biology of myocardial ischemia

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7 January 2021

Kidney ischemic preconditioning

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7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

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7 January 2021

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury

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7 January 2021

Effects of whole-body hypoxic preconditioning on hypoxia/reoxygenation-induced intestinal injury in newborn rats

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7 January 2021

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

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7 January 2021

HIF-1alpha is essential for myeloid cell-mediated inflammation

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7 January 2021

Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation

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7 January 2021

Hypoxia-induced gene activity in disused oxidative muscle.

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7 January 2021

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades

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7 January 2021

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

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7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

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7 January 2021

Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases

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7 January 2021

Cerebral preconditioning and ischaemic tolerance

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7 January 2021

Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors

1 reference

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7 January 2021

HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration

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7 January 2021

Syncatalytic inactivation of prolyl 4-hydroxylase by anthracyclines

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7 January 2021

Hypoxia-inducible factors in the kidney

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7 January 2021

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

1 reference

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7 January 2021

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

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7 January 2021

Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Carbon monoxide from heme oxygenase-2 Is a tonic regulator against NO-dependent vasodilatation in the adult rat cerebral microcirculation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

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7 January 2021

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

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7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

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7 January 2021

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

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7 January 2021

Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain

1 reference

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7 January 2021

Hypoxic preconditioning produces differential expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and its regulatory enzyme HIF prolyl hydroxylase 2 in neonatal rat brain.

1 reference

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7 January 2021

Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium

1 reference

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7 January 2021

Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway.

1 reference

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7 January 2021

Preconditioning improves function and recovery of single muscle fibers during severe hypoxia and reoxygenation

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7 January 2021

The protective role of heme oxygenase-1 on the liver after hypoxic preconditioning in rats

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7 January 2021

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

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7 January 2021

The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis

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7 January 2021

Hypoxic preconditioning and tolerance via hypoxia inducible factor (HIF) 1alpha-linked induction of P450 2C11 epoxygenase in astrocytes

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7 January 2021

Novel strategies for stimulating erythropoiesis and potential new treatments for anaemia

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7 January 2021

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

1 reference

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7 January 2021

Loss of skeletal muscle HIF-1alpha results in altered exercise endurance

1 reference

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7 January 2021

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Hypoxia-inducible factor as a physiological regulator

1 reference

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

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7 January 2021

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

1 reference

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7 January 2021

HIF activation by pH-dependent nucleolar sequestration of VHL.

1 reference

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7 January 2021

Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element

1 reference

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7 January 2021

Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.

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7 January 2021

Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study

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7 January 2021

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium

1 reference

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7 January 2021

Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury

1 reference

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7 January 2021

Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation

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7 January 2021

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

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7 January 2021

Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury.

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7 January 2021

Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer

1 reference

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7 January 2021

Mutations of von Hippel-Lindau tumor-suppressor gene and congenital polycythemia.

1 reference

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7 January 2021

Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo

1 reference

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7 January 2021

Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS.

1 reference

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7 January 2021

Stabilization of hypoxia inducible factor rather than modulation of collagen metabolism improves cardiac function after acute myocardial infarction in rats

1 reference

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7 January 2021

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

1 reference

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7 January 2021

Understanding hypoxia signalling in cells--a new therapeutic opportunity?

1 reference

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7 January 2021

Cellular responses to hypoxia after renal segmental infarction

1 reference

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7 January 2021

Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys

1 reference

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7 January 2021

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Hypoxic preconditioning triggers myocardial angiogenesis: a novel approach to enhance contractile functional reserve in rat with myocardial infarction

1 reference

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7 January 2021

Ischemic preconditioning: clinical relevance and investigative studies

1 reference

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7 January 2021

Oxygen sensing by HIF hydroxylases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

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7 January 2021

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

1 reference

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7 January 2021

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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7 January 2021

Novel applications of recombinant erythropoietin

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Hypoxic preconditioning of ischaemic canine myocardium

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Hypoxic preconditioning attenuates stunning caused by repeated coronary artery occlusions in dog heart

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

1 reference

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7 January 2021

HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Hypoxia-inducible factor modulates tubular cell survival in cisplatin nephrotoxicity

1 reference

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7 January 2021

Inhibition of ischemia/reperfusion injury and chronic graft deterioration by a single-donor treatment with cobalt-protoporphyrin for the induction of heme oxygenase-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Role of endogenous vascular endothelial growth factor in tubular cell protection against acute cyclosporine toxicity

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7 January 2021

Purification and characterization of hypoxia-inducible factor 1

1 reference

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7 January 2021

Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppression.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Inconsistent effects of acidosis on HIF-alpha protein and its target genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1alpha and AP-1 and iNOS signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Induction of hypoxia inducible factor-1 attenuates metabolic insults induced by 3-nitropropionic acid in rat C6 glioma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Whole-body hypoxic preconditioning protects mice against acute hypoxia by improving lung function.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

Hypoxic preconditioning and erythropoietin protect retinal neurons from degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2935012-X

7 January 2021

10.1016/S0076-6879(07)35012-X

Identifiers

DOI

1 reference

17 August 2017

1 reference