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Microglia dynamics and function in the CNS.
scientific article published on 10 August 2010
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scholarly article
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Europe PubMed Central
PMCID
3708473
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17 August 2017
review article
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Europe PubMed Central
title
Microglia dynamics and function in the CNS.
(English)
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Europe PubMed Central
PMCID
3708473
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17 August 2017
main subject
microglia
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author name string
Christopher N Parkhurst
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1
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Europe PubMed Central
PMCID
3708473
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17 August 2017
Wen-Biao Gan
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2
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PMCID
3708473
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17 August 2017
language of work or name
English
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publication date
10 August 2010
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Europe PubMed Central
PMCID
3708473
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17 August 2017
published in
Current Opinion in Neurobiology
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Europe PubMed Central
PMCID
3708473
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17 August 2017
volume
20
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Europe PubMed Central
PMCID
3708473
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17 August 2017
issue
5
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Europe PubMed Central
PMCID
3708473
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17 August 2017
page(s)
595-600
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Europe PubMed Central
PMCID
3708473
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17 August 2017
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P2Y12 receptor-mediated integrin-beta1 activation regulates microglial process extension induced by ATP
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Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain
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Microglial activation by Citrobacter koseri is mediated by TLR4- and MyD88-dependent pathways
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The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis.
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Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury
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Microglia processes block the spread of damage in the brain and require functional chloride channels
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Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity
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29 September 2017
ATP and NO dually control migration of microglia to nerve lesions
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29 September 2017
Fibrillar amyloid-beta peptides activate microglia via TLR2: implications for Alzheimer's disease
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29 September 2017
A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS.
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29 September 2017
The P2Y12 receptor regulates microglial activation by extracellular nucleotides
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PubMed Central
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29 September 2017
ATP mediates rapid microglial response to local brain injury in vivo
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PubMed Central
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29 September 2017
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
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29 September 2017
Signalling pathways of the TNF superfamily: a double-edged sword
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29 September 2017
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
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29 September 2017
Individual microglia move rapidly and directly to nerve lesions in the leech central nervous system
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29 September 2017
The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstruction
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27 June 2018
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
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27 June 2018
Attenuation of proliferation in oligodendrocyte precursor cells by activated microglia
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4 September 2018
Critical role of TLR4 response in the activation of microglia induced by ethanol
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
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4 September 2018
The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
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4 September 2018
Glutamate induces directed chemotaxis of microglia.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
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4 September 2018
Activation of microglia by amyloid {beta} requires P2X7 receptor expression
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
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4 September 2018
Microglia protect neurons against ischemia by synthesis of tumor necrosis factor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
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4 September 2018
Live imaging of Toll-like receptor 2 response in cerebral ischaemia reveals a role of olfactory bulb microglia as modulators of inflammation.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
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4 September 2018
P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
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4 September 2018
Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
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4 September 2018
Monocyte chemoattractant protein-1 (MCP-1) produced via NF-kappaB signaling pathway mediates migration of amoeboid microglia in the periventricular white matter in hypoxic neonatal rats.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
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4 September 2018
Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
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4 September 2018
A 2A adenosine receptor regulates glia proliferation and pain after peripheral nerve injury
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
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4 September 2018
Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
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4 September 2018
P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
retrieved
4 September 2018
Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7 receptor-mediated IL-1beta release
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
retrieved
4 September 2018
P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
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4 September 2018
Resting microglial motility is independent of synaptic plasticity in mammalian brain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
retrieved
4 September 2018
P2X(7) receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamate transport
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
retrieved
4 September 2018
Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
retrieved
4 September 2018
Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
retrieved
4 September 2018
Entry and distribution of microglial cells in human embryonic and fetal cerebral cortex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
retrieved
4 September 2018
Purines induce directed migration and rapid homing of microglia to injured pyramidal neurons in developing hippocampus.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
retrieved
4 September 2018
ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
retrieved
4 September 2018
Time course of proliferation and elimination of microglia/macrophages in different neurodegenerative conditions.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
retrieved
4 September 2018
Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3708473
retrieved
4 September 2018
Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20705452
retrieved
12 December 2020
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inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CONB.2010.07.002
1 reference
stated in
Europe PubMed Central
PMCID
3708473
retrieved
17 August 2017
Fatcat ID
release_7qjhp6nlnzbutgplbz3pkqjji4
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Fatcat
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https://api.fatcat.wiki/v0/release/7qjhp6nlnzbutgplbz3pkqjji4
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
PMCID
3708473
1 reference
stated in
Europe PubMed Central
PMCID
3708473
retrieved
17 August 2017
PubMed ID
20705452
1 reference
stated in
Europe PubMed Central
PMCID
3708473
retrieved
17 August 2017
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