(Q37004725)

17 August 2017

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title

Targeting insulin-like growth factor-1 to treat Alzheimer's disease (English)

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17 August 2017

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1 reference

Ignacio Torres-Aleman

series ordinal

1

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17 August 2017

language of work or name

English

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publication date

1 December 2007

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Expert Opinion on Therapeutic Targets

17 August 2017

published in

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17 August 2017

volume

11

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17 August 2017

issue

12

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17 August 2017

page(s)

1535-1542

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Alzheimer disease therapy: can the amyloid cascade be halted?

17 August 2017

cites work

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Clearing the brain's amyloid cobwebs

21 January 2018

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Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

21 January 2018

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Inhibition of neurofibrillary degeneration: a promising approach to Alzheimer's disease and other tauopathies

21 January 2018

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The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review

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Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type

21 January 2018

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Increased risk of type 2 diabetes in Alzheimer disease

21 January 2018

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Potential roles of insulin and IGF-1 in Alzheimer's disease.

21 January 2018

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The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease

21 January 2018

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Food intake and serum insulin responses to intraventricular infusions of insulin and IGF-I

21 January 2018

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Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors.

21 January 2018

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The insulin-like growth factor system and its pleiotropic functions in brain

21 January 2018

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Clinical utility of measurements of insulin-like growth factor 1.

21 January 2018

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Role of serum insulin-like growth factor I in mammalian brain aging.

21 January 2018

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Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic-ischemic injury

21 January 2018

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Transport of insulin-related peptides and glucose across the blood-brain barrier

21 January 2018

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Serum growth factors and neuroprotective surveillance: focus on IGF-1.

21 January 2018

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New roles for VEGF in nervous tissue--beyond blood vessels

21 January 2018

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Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

21 January 2018

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Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights

21 January 2018

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Learning of the conditioned eye-blink response is impaired by an antisense insulin-like growth factor I oligonucleotide

21 January 2018

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21 January 2018

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21 January 2018

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Decreased plasma insulin-like growth factor-I level in familial Alzheimer's disease patients carrying the Swedish APP 670/671 mutation.

21 January 2018

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Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type.

21 January 2018

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Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice.

21 January 2018

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Serum insulin-like growth factor I in brain function

21 January 2018

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Insulin and insulin-like growth factor I signalling in neurons

21 January 2018

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Ageing and local growth factors in muscle

21 January 2018

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Distribution and levels of insulin-like growth factor I mRNA across the life span in the Brown Norway x Fischer 344 rat brain

21 January 2018

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21 January 2018

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Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

21 January 2018

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Serum insulin-like growth factor I regulates brain amyloid-beta levels

21 January 2018

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IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways

21 January 2018

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Tau is hyperphosphorylated in the insulin-like growth factor-I null brain

21 January 2018

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Peripheral hyperinsulinemia promotes tau phosphorylation in vivo

21 January 2018

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Inflammation and Alzheimer's disease

21 January 2018

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The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease

21 January 2018

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Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

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Calcineurin in reactive astrocytes plays a key role in the interplay between proinflammatory and anti-inflammatory signals

21 January 2018

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Reactive oxygen species have a causal role in multiple forms of insulin resistance

21 January 2018

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RETRACTED: A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide

21 January 2018

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Endocrine regulation of ageing

21 January 2018

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Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction

21 January 2018

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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

21 January 2018

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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

21 January 2018

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The common biology of cancer and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Alzheimer's disease is a synaptic failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Effects of insulin-like growth factor I on climbing fibre synapse elimination during cerebellar development

21 January 2018

1 reference

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Transynaptic modulation by insulin-like growth factor I of dendritic spines in Purkinje cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Will a healthy lifestyle help prevent Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Insulin-like growth factor I is required for vessel remodeling in the adult brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Molecular pathways to neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Glutamate excitotoxicity attenuates insulin-like growth factor-I prosurvival signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

'Unfolding' pathways in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

The effect of neurodegenerative diseases on the subventricular zone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Insulin-like growth factor-I and neurogenesis in the adult mammalian brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Does insulin dysfunction play a role in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Neuroscience. Insulin insults may spur Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

Role of insulin-like growth factors in neuronal plasticity and neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.12.1535

10.1517/14728222.11.12.1535

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference