(Q37014106)

English

Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior.

scientific article published on January 2013

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22 February 2020

Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior (English)

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22 February 2020

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allosteric inhibitor

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based on heuristic

inferred from title

Alexander Agarkov

4

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22 February 2020

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22 February 2020

Fernanda Laezza

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22 February 2020

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22 February 2020

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Noelle C Anastasio

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22 February 2020

Scott R Gilbertson

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22 February 2020

Marcy J Bubar

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22 February 2020

Sonja J Stutz

5

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22 February 2020

Yowjiun Jeng

6

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22 February 2020

Nicole M Bremer

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22 February 2020

Thressa D Smith

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22 February 2020

Robert G Fox

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22 February 2020

Sarah E Swinford

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22 February 2020

Patricia K Seitz

11

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22 February 2020

Marc N Charendoff

12

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22 February 2020

Cheryl S Watson

15

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22 February 2020

Kathryn A Cunningham

17

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22 February 2020

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1 January 2013

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22 February 2020

Journal of Neuroscience

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22 February 2020

33

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22 February 2020

4

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22 February 2020

1615-1630

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22 February 2020

All-atom empirical potential for molecular modeling and dynamics studies of proteins

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29 September 2017

Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction

1 reference

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Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT2C receptor allosteric modulators

1 reference

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Quantitative changes in intracellular calcium and extracellular-regulated kinase activation measured in parallel in CHO cells stably expressing serotonin (5-HT) 5-HT2A or 5-HT2C receptors

1 reference

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Synthesis and evaluation of dimeric derivatives of 5-HT(2A) receptor (5-HT(2A)R) antagonist M-100907.

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Selective serotonin 5-HT(2C) receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues

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G protein coupled receptors as allosteric proteins and the role of allosteric modulators

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Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.

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Serotonin 5-HT2C receptor protein expression is enriched in synaptosomal and post-synaptic compartments of rat cortex

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PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors

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5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

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Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse

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Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling.

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Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions

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The neuropharmacology of impulsive behaviour

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Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test

1 reference

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Serotonin2C receptor localization in GABA neurons of the rat medial prefrontal cortex: implications for understanding the neurobiology of addiction

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Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors

1 reference

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Pharmacological profile of the 5-HT(2C) receptor agonist WAY-163909; therapeutic potential in multiple indications

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Role of the anterior cingulate and medial orbitofrontal cortex in processing drug cues in cocaine addiction

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Direct observation of individual endogenous protein complexes in situ by proximity ligation

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Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability

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Pharmacology. Hitting the hot spots of cell signaling cascades

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Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse

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Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503.

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Scalable molecular dynamics with NAMD

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Central serotonin and melanocortin pathways regulating energy homeostasis

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Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats.

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Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding

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The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry

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Multiplicity of mechanisms of serotonin receptor signal transduction

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Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors

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5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion

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Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior

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4 September 2018

Positive allosteric modulator of the human 5-HT2C receptor

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Rapid desensitization of the serotonin(2C) receptor system: effector pathway and agonist dependence

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711763

4 September 2018

Differences in rapid desensitization of 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptor-mediated phospholipase C activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711763

4 September 2018

Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711763

4 September 2018

Hydrophobic docking: a proposed enhancement to molecular recognition techniques.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711763

4 September 2018

Computed circular dichroism spectra for the evaluation of protein conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23345234

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of small cyclic peptides via reverse turn induced ring closing metathesis of tripeptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/23345234

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Software news and updates. Carma: a molecular dynamics analysis program

1 reference

https://pubmed.ncbi.nlm.nih.gov/23345234

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma insulin, tryptophan and serotonin levels during the glucose tolerance test among habitually violent and impulsive offenders

1 reference

https://pubmed.ncbi.nlm.nih.gov/23345234

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of specific hydrophobic, but not hydrophilic, amino acids in the third intracellular loop of the beta-adrenergic receptor in the activation of Gs

1 reference

https://pubmed.ncbi.nlm.nih.gov/23345234

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid method for the regional dissection of the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/23345234

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural analysis of integrin recognition and the inhibition of integrin-mediated cell functions by novel nonpeptidic surrogates of the Arg-Gly-Asp sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/23345234

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.2656-12.2013

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23345234%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23345234%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23345234%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

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