(Q46065953)

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Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21929287

Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms (English)

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21929287

G protein-coupled receptor

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PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21929287

Roberta Ghidoni

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19 December 2017

http://europepmc.org/abstract/MED/21929287

Susanna Genedani

10

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19 December 2017

http://europepmc.org/abstract/MED/21929287

11

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21929287

Michele Guescini

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Michele Guescini

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Marina Pizzi

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Francisco Ciruela

9

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Francisco Ciruela

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19 December 2017

http://europepmc.org/abstract/MED/21929287

3

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Giuseppina Leo

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19 December 2017

http://europepmc.org/abstract/MED/21929287

Luigi Francesco Agnati

1

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Luigi Francesco Agnati

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19 December 2017

http://europepmc.org/abstract/MED/21929287

Vilberto Stocchi

6

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Vilberto Stocchi

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Europe PubMed Central

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19 December 2017

http://europepmc.org/abstract/MED/21929287

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Pier Francesco Spano

7

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19 December 2017

http://europepmc.org/abstract/MED/21929287

publication date

1 October 2011

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21929287

Journal of Receptors and Signal Transduction

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21929287

31

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21929287

5

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21929287

315-331

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Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21929287

GPCR drug discovery through the exploitation of allosteric drug binding sites

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Current perspectives on the selective regulation of dopamine D₂ and D₃ receptors

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

The psychiatric side-effects of rimonabant

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

A robustness-based approach to systems-oriented drug design.

1 reference

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21 January 2018

Characterization of dopamine receptors in various species of invertebrates and vertebrates

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Understanding wiring and volume transmission.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

New concepts on the structure of the neuronal networks: the miniaturization and hierarchical organization of the central nervous system. (Hypothesis).

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Understanding neuronal molecular networks builds on neuronal cellular network architecture

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

G protein coupled receptors as allosteric proteins and the role of allosteric modulators

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Ligand detection in the allosteric world

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Structural plasticity in G-protein coupled receptors as demonstrated by the allosteric actions of homocysteine and computer-assisted analysis of disordered domains.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Allosteric regulation and catalysis emerge via a common route.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Allosteric proteins and cellular control systems

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Allostery: an illustrated definition for the 'second secret of life'.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Is allostery an intrinsic property of all dynamic proteins?

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Modular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkages

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Cooperativity and biological complexity

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Allosteric theory: taking therapeutic advantage of the malleable nature of GPCRs

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

'7TM receptor allostery: putting numbers to shapeshifting proteins

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Structural symmetry and protein function

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Evolutionarily conserved networks of residues mediate allosteric communication in proteins

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Receptor-receptor interactions: A novel concept in brain integration

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Allosteric communication occurs via networks of tertiary and quaternary motions in proteins

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Caveolins, liquid-ordered domains, and signal transduction

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

How receptor mosaics decode transmitter signals. Possible relevance of cooperativity.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Exploring a role for heteromerization in GPCR signalling specificity

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

The changing world of G protein-coupled receptors: from monomers to dimers and receptor mosaics with allosteric receptor-receptor interactions

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Domains in biological membranes

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Docosahexaenoic acid modifies the clustering and size of lipid rafts and the lateral organization and surface expression of MHC class I of EL4 cells

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Signalosomes as Therapeutic Targets

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

The brain as a system of nested but partially overlapping networks. Heuristic relevance of the model for brain physiology and pathology.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Receptor-receptor interactions, receptor mosaics, and basic principles of molecular network organization: possible implications for drug development

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Voltage-dependent anion channel as a resident protein of lipid rafts: post-transductional regulation by estrogens and involvement in neuronal preservation against Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Cardioprotective signaling to mitochondria

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Real-time monitoring of membrane cholesterol reveals new insights into epidermal differentiation

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Lipid membrane interactions of indacaterol and salmeterol: do they influence their pharmacological properties?

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Allosteric modulation of heterodimeric G-protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

The fluid mosaic model of the structure of cell membranes

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Determinants of specificity at the protein-lipid interface in membranes

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Spatial organization of transmembrane receptor signalling

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Plasma membrane microdomains in aging and disease

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

G protein-coupled receptor systems and their lipid environment in health disorders during aging.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Membrane-associated stress proteins: more than simply chaperones.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

The complex regulation of receptor-coupled G-proteins

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Evidence for disaggregation of oligomeric G(o)alpha induced by guanosine-5;-3-O-(thio)triphosphate activation

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

A boolean network modelling of receptor mosaics relevance of topology and cooperativity

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Lateral organization of membrane proteins: tetraspanins spin their web.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Shedding microvesicles: artefacts no more

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Membrane vesicles as conveyors of immune responses

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Exosomes--vesicular carriers for intercellular communication

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Exosomes/microvesicles as a mechanism of cell-to-cell communication

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Exosomes: extracellular organelles important in intercellular communication

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Epigenetic influences on brain development and plasticity

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Epigenetic principles and mechanisms underlying nervous system functions in health and disease

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Perceptions of epigenetics

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Deconstructing the dogma: a new view of the evolution and genetic programming of complex organisms.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Epigenetic programming by maternal behavior

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Epigenetic transgenerational actions of endocrine disruptors and male fertility

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Transcription factors in long-term memory and synaptic plasticity

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Molecular basis of lysophosphatidic acid-induced NF-κB activation

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Angiotensin II-induced upregulation of AT(1) receptor expression: sequential activation of NF-kappaB and Elk-1 in neurons

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Distinct roles of diverse nuclear factor-kappaB complexes in neuropathological mechanisms.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

NF-kappaB RelA phosphorylation regulates RelA acetylation

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Regulation of transcription factors by neuronal activity.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

NF-kappa B functions in synaptic signaling and behavior

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Opposing roles for NF-kappa B/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1beta

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

NF-kappaB pathway: a target for preventing beta-amyloid (Abeta)-induced neuronal damage and Abeta42 production

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

NF-kappaB p50/RelA and c-Rel-containing dimers: opposite regulators of neuron vulnerability to ischaemia.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

G protein-coupled receptor allosterism and complexing

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Cholesterol, lipid rafts, and disease

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Targeting of tetraspanin proteins--potential benefits and strategies

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Tetraspanins in viral infections: a fundamental role in viral biology?

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Evolvability and hierarchy in rewired bacterial gene networks

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Generation of neuronal variability and complexity

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Epigenetic control of the S100A6 (calcyclin) gene expression

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

RNA editing, DNA recoding and the evolution of human cognition

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Noncoding RNAs: couplers of analog and digital information in nervous system function?

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Epigenetics and complex disease: from etiology to new therapeutics

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Modulating the expression of disease genes with RNA-based therapy.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Modelling the dynamics of the yeast pheromone pathway.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Modeling the binding and function of metabotropic glutamate receptors.

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Self organization of membrane proteins via dimerization

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2011.599393

21 January 2018

Identifiers

10.3109/10799893.2011.599393

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21929287

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 December 2017

http://europepmc.org/abstract/MED/21929287

ResearchGate publication ID

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