(Q37014638)

English

Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action

scientific article published on March 2006

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scholarly article

1 reference

Europe PubMed Central

17 August 2017

Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action (English)

1 reference

Europe PubMed Central

17 August 2017

0 references

object named as

Lucia Nencioni

12

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Clementina Maria Galluzzo

object named as

Clementina Maria Galluzzo

11

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object named as

Roberta Costi

2

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Luciana Marinelli

object named as

Luciana Marinelli

6

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Mauro Andreotti

object named as

Mauro Andreotti

9

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Antonio Lavecchia

object named as

Antonio Lavecchia

5

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Roberto Di Santo

object named as

Roberto Di Santo

1

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Anna Teresa Palamara

object named as

Anna Teresa Palamara

13

0 references

Ettore Novellino

object named as

Ettore Novellino

7

0 references

14

object named as

Yves Pommier

1 reference

Europe PubMed Central

17 August 2017

Christophe H Marchand

15

object named as

Christophe Marchand

1 reference

Europe PubMed Central

17 August 2017

Alessandra Roux

3

object named as

Alessandra Roux

1 reference

Europe PubMed Central

17 August 2017

4

object named as

Marino Artico

1 reference

Europe PubMed Central

17 August 2017

Lucia Palmisano

8

object named as

Lucia Palmisano

1 reference

Europe PubMed Central

17 August 2017

10

object named as

Roberta Amici

1 reference

Europe PubMed Central

17 August 2017

language of work or name

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publication date

1 March 2006

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Europe PubMed Central

17 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

17 August 2017

49

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Europe PubMed Central

17 August 2017

6

1 reference

Europe PubMed Central

17 August 2017

1939-1945

1 reference

Europe PubMed Central

17 August 2017

Clinical practice. Management of newly diagnosed HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Design, synthesis and biological evaluation of heteroaryl diketohexenoic and diketobutanoic acids as HIV-1 integrase inhibitors endowed with antiretroviral activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Integrase inhibitors to treat HIV/AIDS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

HIV-1 integrase inhibitors: a decade of research and two drugs in clinical trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implication for binding to two metal ions on the active site of integrase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

2,6-Bis(3,4,5-trihydroxybenzylydene) derivatives of cyclohexanone: novel potent HIV-1 integrase inhibitors that prevent HIV-1 multiplication in cell-based assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Molecular dynamics studies on the HIV-1 integrase catalytic domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Inhibitors of human immunodeficiency virus integrase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Inhibitory effect of the polyanionic drug suramin on the in vitro HIV DNA integration reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Inhibition of HIV-1 integration protein by aurintricarboxylic acid monomers, monomer analogs, and polymer fractions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Mutational analysis of the integrase protein of human immunodeficiency virus type 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

29 September 2017

Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

27 June 2018

6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

4 September 2018

Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

4 September 2018

Modeling HIV-1 integrase complexes based on their hydrodynamic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

4 September 2018

VEGA: a versatile program to convert, handle and visualize molecular structure on Windows-based PCs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

4 September 2018

Therapies. Confronting the limits of success.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

4 September 2018

Computational drug design accommodating receptor flexibility: the relaxed complex scheme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

4 September 2018

Structural determinants for HIV-1 integrase inhibition by beta-diketo acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602756

4 September 2018

Identifiers

10.1021/JM0511583

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

1 reference

Europe PubMed Central

17 August 2017

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