(Q37023918)

17 August 2017

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title

Histone deacetylases: target enzymes for cancer therapy (English)

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17 August 2017

1

Denis Mottet

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17 August 2017

2

Vincent Castronovo

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17 August 2017

publication date

5 December 2007

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Clinical & Experimental Metastasis

17 August 2017

published in

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17 August 2017

volume

25

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17 August 2017

issue

2

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17 August 2017

page(s)

183-189

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https://scigraph.springernature.com/pub.10.1007/s10585-007-9131-5

17 August 2017

exact match

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cites work

Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10585-007-9131-5

The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance.

21 January 2018

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12 December 2020

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12 December 2020

Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin

1 reference

12 December 2020

Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis

1 reference

12 December 2020

Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB.

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12 December 2020

Genes modulated by histone acetylation as new effectors of butyrate activity

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12 December 2020

Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo

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12 December 2020

The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.

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12 December 2020

Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells

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12 December 2020

Depsipeptide inhibits migration of primary and metastatic uveal melanoma cell lines in vitro: a potential strategy for uveal melanoma

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12 December 2020

Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors

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12 December 2020

The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells

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12 December 2020

Histone deacetylases (HDACs): characterization of the classical HDAC family

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12 December 2020

Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling

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12 December 2020

Inhibitors of histone deacetylases induce tumor-selective cytotoxicity through modulating Aurora-A kinase

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12 December 2020

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

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12 December 2020

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

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12 December 2020

The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide

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12 December 2020

Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase

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12 December 2020

Valproic acid inhibits angiogenesis in vitro and in vivo

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12 December 2020

Post-transcriptional regulation of endothelial nitric-oxide synthase by an overlapping antisense mRNA transcript

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12 December 2020

Histone deacetylase inhibitor, FK228, induces apoptosis and suppresses cell proliferation of human glioblastoma cells in vitro and in vivo

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12 December 2020

Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites.

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12 December 2020

Drug insight: Histone deacetylase inhibitors--development of the new targeted anticancer agent suberoylanilide hydroxamic acid

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12 December 2020

The human histone deacetylase family

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12 December 2020

Histone deacetylase inhibitors promote apoptosis and differential cell cycle arrest in anaplastic thyroid cancer cells

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12 December 2020

Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10

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12 December 2020

Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824.

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12 December 2020

Acetylation and deacetylation of non-histone proteins

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12 December 2020

p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y

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12 December 2020

Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

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12 December 2020

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

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12 December 2020

Suberoylanilide hydroxamic acid as a potential therapeutic agent for human breast cancer treatment

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12 December 2020

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

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12 December 2020

Role of the histone deacetylase complex in acute promyelocytic leukaemia

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12 December 2020

Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK.

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12 December 2020

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo

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12 December 2020

Bim plays a crucial role in synergistic induction of apoptosis by the histone deacetylase inhibitor SBHA and TRAIL in melanoma cells

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12 December 2020

Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion.

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12 December 2020

Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy

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12 December 2020

Histone deacetylase inhibitors: development as cancer therapy.

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12 December 2020

Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity

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12 December 2020

Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589.

1 reference

12 December 2020

Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors.

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12 December 2020

Depsipeptide a histone deacetlyase inhibitor down regulates levels of matrix metalloproteinases 2 and 9 mRNA and protein expressions in lung cancer cells (A549).

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12 December 2020

Functional interplay between modulation of histone deacetylase activity and its regulatory role in G2–M transition

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12 December 2020

Histone deacetylases, transcriptional control, and cancer

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12 December 2020

Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR

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12 December 2020

Histone deacetylase inhibitors: from target to clinical trials

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12 December 2020

Trichostatin A Induces Morphological Changes and Gelsolin Expression by Inhibiting Histone Deacetylase in Human Carcinoma Cell Lines

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12 December 2020

Histone acetylation and disease

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12 December 2020

Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials

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12 December 2020

The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584.

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12 December 2020

Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells

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12 December 2020

p21Waf1/Cip1 is a common target induced by short-chain fatty acid HDAC inhibitors (valproic acid, tributyrin and sodium butyrate) in neuroblastoma cells.

1 reference

12 December 2020

Paradoxical effects of trichostatin A: inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and downregulation of cyclin A and B1 mRNA.

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12 December 2020

Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis

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12 December 2020

The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code.

1 reference

12 December 2020

Histone deacetylase 7 silencing alters endothelial cell migration, a key step in angiogenesis

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12 December 2020

The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells.

1 reference

12 December 2020

Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer.

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12 December 2020

Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90.

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12 December 2020

Histone deacetylase inhibitor suppression of autoantibody-mediated arthritis in mice via regulation of p16INK4a and p21(WAF1/Cip1) expression

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12 December 2020

Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications

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12 December 2020

Histone acetylation modifiers in the pathogenesis of malignant disease

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12 December 2020

Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines

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12 December 2020

Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells

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12 December 2020

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

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12 December 2020

10.1007/S10585-007-9131-5

Identifiers

DOI

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17 August 2017

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