(Q37029352)

17 August 2017

1 reference

title

The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications (English)

1 reference

17 August 2017

0 references

Qingguang Jiang

1

1 reference

17 August 2017

Michael Heneka

series ordinal

2

1 reference

17 August 2017

Gary E Landreth

series ordinal

3

1 reference

17 August 2017

language of work or name

1 reference

1 January 2008

1 reference

17 August 2017

1 reference

17 August 2017

volume

22

1 reference

17 August 2017

issue

1

1 reference

17 August 2017

page(s)

1-14

1 reference

Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study

17 August 2017

cites work

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200822010-00001

Mouse models of Alzheimer's disease: insight into treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200822010-00001

Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200822010-00001

Endothelial inflammation in insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200822010-00001

Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200822010-00001

Apolipoproteins modulate the inflammatory response to lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200822010-00001

Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200822010-00001

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F00023210-200822010-00001

Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease.

21 January 2018

1 reference

12 December 2020

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

1 reference

12 December 2020

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

1 reference

12 December 2020

Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype.

1 reference

12 December 2020

Emerging roles of PPARs in inflammation and immunity

1 reference

12 December 2020

Insulin resistance in depressive disorders and Alzheimer's disease: revisiting the missing link hypothesis

1 reference

12 December 2020

Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism

1 reference

12 December 2020

Cardiovascular risk factors and Alzheimer's disease

1 reference

12 December 2020

A rational approach to pathogenesis and treatment of type 2 diabetes mellitus, insulin resistance, inflammation, and atherosclerosis

1 reference

12 December 2020

Pioglitazone: update on an oral antidiabetic drug with antiatherosclerotic effects

1 reference

12 December 2020

Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study.

1 reference

12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

12 December 2020

Neurodegenerative disorders associated with diabetes mellitus

1 reference

12 December 2020

Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression

1 reference

12 December 2020

Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?

1 reference

12 December 2020

Apolipoprotein E suppresses the type I inflammatory response in vivo

1 reference

12 December 2020

Hyperinsulinaemia and Alzheimer's disease.

1 reference

12 December 2020

Genetic discoveries as the basis of personalized therapy: rosiglitazone treatment of Alzheimer's disease.

1 reference

12 December 2020

Gene expression in atherosclerotic lesion of ApoE deficient mice

1 reference

12 December 2020

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

1 reference

12 December 2020

Effect of endotoxin on cholesterol biosynthesis and distribution in serum lipoproteins in Syrian hamsters

1 reference

12 December 2020

IKK-beta links inflammation to obesity-induced insulin resistance

1 reference

12 December 2020

Cyp46 (24S-cholesterol hydroxylase): a genetic risk factor for Alzheimer disease

1 reference

12 December 2020

Insulin resistance, inflammation, and the prediabetic state

1 reference

12 December 2020

Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines.

1 reference

12 December 2020

Role of inflammation in neurodegenerative diseases

1 reference

12 December 2020

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice

1 reference

12 December 2020

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

1 reference

12 December 2020

Insulin resistance, inflammation, and cognition in Alzheimer's Disease: lessons for multiple sclerosis

1 reference

12 December 2020

Phosphorylation of PPARγ via active ERK1/2 leads to its physical association with p65 and inhibition of NF‐κβ

1 reference

12 December 2020

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

1 reference

12 December 2020

Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults

1 reference

12 December 2020

PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice

1 reference

12 December 2020

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

1 reference

12 December 2020

Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation

1 reference

12 December 2020

Orphan nuclear receptors: shifting endocrinology into reverse

1 reference

12 December 2020

Nuclear hormone receptors and gene expression

1 reference

12 December 2020

Roles of PPARs in health and disease.

1 reference

12 December 2020

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

1 reference

12 December 2020

Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study

1 reference

12 December 2020

PPARgamma as a therapeutic target in central nervous system diseases

1 reference

12 December 2020

Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

1 reference

12 December 2020

Anti-inflammatory agents in Alzheimer's disease

1 reference

12 December 2020

Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene.

1 reference

12 December 2020

Are cerebrovascular factors involved in Alzheimer's disease?

1 reference

12 December 2020

Effect of LPS on basal and induced apo E secretion by 25-OH chol and 9cRA in differentiated CaCo-2.

1 reference

12 December 2020

Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort

1 reference

12 December 2020

Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender.

1 reference

12 December 2020

Apolipoprotein-E epsilon-4 is associated with increased neurofibrillary pathology in the Lewy body variant of Alzheimer's disease

1 reference

12 December 2020

Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains

1 reference

12 December 2020

Inflammation and Alzheimer's disease: mechanisms and therapeutic strategies

1 reference

12 December 2020

Insulin resistance and the endothelium

1 reference

12 December 2020

Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures

1 reference

12 December 2020

Alzheimer's disease: the cholesterol connection

1 reference

12 December 2020

Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease.

1 reference

12 December 2020

Cyclooxygenase-independent actions of cyclooxygenase inhibitors

1 reference

12 December 2020

APOE is a major susceptibility gene for Alzheimer's disease

1 reference

12 December 2020

Combinatorial roles of nuclear receptors in inflammation and immunity

1 reference

12 December 2020

Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: a longitudinal study.

1 reference

12 December 2020

The many faces of PPARgamma

1 reference

12 December 2020

Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils

1 reference

12 December 2020

Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effects

1 reference

12 December 2020

Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional study

1 reference

12 December 2020

Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?

1 reference

12 December 2020

Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease

1 reference

12 December 2020

Hippocampal formation glucose metabolism and volume losses in MCI and AD.

1 reference

12 December 2020

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

1 reference

12 December 2020

Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs

1 reference

12 December 2020

Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death.

1 reference

12 December 2020

Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation

1 reference

12 December 2020

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

1 reference

12 December 2020

Brain cholesterol: long secret life behind a barrier.

1 reference

12 December 2020

Patterns of brain activation in people at risk for Alzheimer's disease.

1 reference

12 December 2020

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

1 reference

12 December 2020

Alzheimer's disease: genetic studies and transgenic models

1 reference

12 December 2020

Enhanced processing of APP induced by IL-1 beta can be reduced by indomethacin and nordihydroguaiaretic acid

1 reference

12 December 2020

Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease

1 reference

12 December 2020

Ibuprofen decreases cytokine-induced amyloid beta production in neuronal cells.

1 reference

12 December 2020

Differential expression of cholesterol hydroxylases in Alzheimer's disease

1 reference

12 December 2020

Downregulation of liver X receptor-alpha in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines

1 reference

12 December 2020

Inflammation and Alzheimer's disease

1 reference

12 December 2020

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

1 reference

12 December 2020

Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment

1 reference

12 December 2020

Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study

1 reference

12 December 2020

Inflammation and insulin resistance

1 reference

12 December 2020

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

1 reference

12 December 2020

Transcriptional control of adipogenesis

1 reference

12 December 2020

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein

1 reference

12 December 2020

Inflammation, apoptosis, and Alzheimer's disease

1 reference

12 December 2020

Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease

1 reference

12 December 2020

1 reference

12 December 2020

Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's disease

1 reference

12 December 2020

Differential modulation of plasma beta-amyloid by insulin in patients with Alzheimer disease.

1 reference

12 December 2020

Insulin resistance, affective disorders, and Alzheimer's disease: review and hypothesis

1 reference

12 December 2020

Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism

1 reference

12 December 2020

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

1 reference

12 December 2020

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

1 reference

12 December 2020

Inflammation and Alzheimer's disease pathogenesis

1 reference

12 December 2020

Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models

1 reference

12 December 2020

Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling

1 reference

12 December 2020

Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype

1 reference

12 December 2020

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

1 reference

12 December 2020

Divergent effects of peroxisome proliferator-activated receptor gamma agonists and tumor necrosis factor alpha on adipocyte ApoE expression.

1 reference

12 December 2020

Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes

1 reference

12 December 2020

Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.

1 reference

12 December 2020

New pharmacological perspectives and therapeutic potential of PPAR-gamma agonists

1 reference

12 December 2020

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

1 reference

12 December 2020

Rosiglitazone induces mitochondrial biogenesis in mouse brain.

1 reference

12 December 2020

The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment

1 reference

12 December 2020

Inflammation: the link between insulin resistance, obesity and diabetes

1 reference

12 December 2020

Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages.

1 reference

12 December 2020

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

1 reference

12 December 2020

Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

1 reference

12 December 2020

Effects of transforming growth factor-beta (isoforms 1-3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures.

1 reference

12 December 2020

Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.

1 reference

12 December 2020

Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice.

1 reference

12 December 2020

Rosiglitazone reduces the accelerated neointima formation after arterial injury in a mouse injury model of type 2 diabetes

1 reference

12 December 2020

Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease

1 reference

12 December 2020

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.

1 reference

12 December 2020

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

1 reference

12 December 2020

Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene

1 reference

12 December 2020

Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis.

1 reference

12 December 2020

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

1 reference

12 December 2020

PPAR(gamma) and glucose homeostasis

1 reference

12 December 2020

The clinical and biological relationship between Type II diabetes mellitus and Alzheimer's disease

1 reference

12 December 2020

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

1 reference

12 December 2020

Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials

1 reference

12 December 2020

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

12 December 2020

Altered PPARgamma expression and activation after transient focal ischemia in rats

1 reference

12 December 2020

Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease.

1 reference

12 December 2020

Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease

1 reference

12 December 2020

Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse

1 reference

12 December 2020

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

1 reference

12 December 2020

The role of insulin, insulin growth factor, and insulin-degrading enzyme in brain aging and Alzheimer's disease

1 reference

12 December 2020

Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300.

1 reference

12 December 2020

The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

1 reference

12 December 2020

Genetic models for CNS inflammation

1 reference

12 December 2020

Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease

1 reference

12 December 2020

The coregulator exchange in transcriptional functions of nuclear receptors

1 reference

12 December 2020

Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures

1 reference

12 December 2020

Interleukin-1beta and glutamate activate the NF-kappaB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures.

1 reference

12 December 2020

Liver X receptors as integrators of metabolic and inflammatory signaling

1 reference

12 December 2020

A perspective on inflammation in Alzheimer's disease.

1 reference

12 December 2020

Inflammation and the degenerative diseases of aging

1 reference

12 December 2020

Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B

1 reference

12 December 2020

The mechanisms of action of PPARs

1 reference

12 December 2020

Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences.

1 reference

12 December 2020

Effects of rosiglitazone and atorvastatin on the expression of genes that control cholesterol homeostasis in differentiating monocytes

1 reference

12 December 2020

Cholesterol and the biology of Alzheimer's disease.

1 reference

12 December 2020

Disposition of the new antidiabetic agent pioglitazone in rats, dogs, and monkeys

1 reference

12 December 2020

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

1 reference

12 December 2020

Pioglitazone: a review of its use in type 2 diabetes mellitus

1 reference

12 December 2020

10.2165/00023210-200822010-00001

Identifiers

DOI

1 reference

Dimensions Publication ID

17 August 2017

1010335399

0 references

1 reference