(Q37036297)

English

Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance

scientific article published on January 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

3

object named as

Peter Wipf

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

8

object named as

Paul Dent

1 reference

Europe PubMed Central

17 August 2017

PMC publication ID

10

object named as

Garth Powis

1 reference

Europe PubMed Central

17 August 2017

PMC publication ID

Gordon B. Mills

7

object named as

Gordon B Mills

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

author name string

Nathan T Ihle

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Robert Lemos

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Adly Yacoub

4

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Clint Mitchell

5

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Doris Siwak

6

1 reference

Europe PubMed Central

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17 August 2017

D Lynn Kirkpatrick

9

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Europe PubMed Central

PMC publication ID

17 August 2017

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publication date

1 January 2009

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Europe PubMed Central

PMC publication ID

17 August 2017

Cancer Research

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Europe PubMed Central

PMC publication ID

17 August 2017

69

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Europe PubMed Central

PMC publication ID

17 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

143-150

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation

1 reference

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RalGDS couples growth factor signaling to Akt activation

1 reference

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TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic cancer cells

1 reference

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The selectivity of protein kinase inhibitors: a further update

1 reference

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4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications

1 reference

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

1 reference

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Predictive medicine: incipient reality or fata morgana?

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KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer

1 reference

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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

1 reference

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Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer

1 reference

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K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling

1 reference

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Exploring the specificity of the PI3K family inhibitor LY294002.

1 reference

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Proteomics-based identification of biomarkers for predicting sensitivity to a PI3-kinase inhibitor in cancer

1 reference

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Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells

1 reference

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Oncogenic PI3K and its role in cancer

1 reference

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High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma

1 reference

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The Akt/PKB pathway: molecular target for cancer drug discovery

1 reference

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Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance

1 reference

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BRAF mutation predicts sensitivity to MEK inhibition

1 reference

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The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

1 reference

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29 September 2017

The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts

1 reference

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Mutant PIK3CA promotes cell growth and invasion of human cancer cells

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

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Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2613546

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The LKB1 tumor suppressor negatively regulates mTOR signaling

1 reference

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Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling

1 reference

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Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin

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Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays

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Distinct requirements for Ras oncogenesis in human versus mouse cells

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1 reference

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Ras enhances Myc protein stability.

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1 reference

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1 reference

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Multiple Ras functions can contribute to mammalian cell transformation

1 reference

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1 reference

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Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase

1 reference

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Non-parametric quantification of protein lysate arrays

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PIK3CA is implicated as an oncogene in ovarian cancer.

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High-throughput oncogene mutation profiling in human cancer

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic H-ras induces cyclin B1 expression in a p53-independent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/19117997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-07-6656

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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