(Q37059452)

18 August 2017

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title

Glial cell dysregulation: a new perspective on Alzheimer disease (English)

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18 August 2017

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Rommy von Bernhardi

1

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18 August 2017

publication date

1 December 2007

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18 August 2017

published in

Neurotoxicity Research

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18 August 2017

volume

12

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18 August 2017

issue

4

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18 August 2017

page(s)

215-232

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https://scigraph.springernature.com/pub.10.1007/bf03033906

18 August 2017

exact match

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cites work

Anti-apoptotic proteins are oxidized by Abeta25-35 in Alzheimer's fibroblasts.

1 reference

https://api.crossref.org/works/10.1007%2FBF03033906

CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033906

Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033906

Mechanisms of beta-amyloid neurotoxicity: perspectives of pharmacotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033906

Expression of scavenger receptor class B, type I, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033906

Pathways of neuron-astrocyte interactions and their possible role in neuroprotection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033906

Neuropathology of cognitively normal elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033906

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033906

Amyloid beta-protein and the genetics of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033906

Activation of human macrophages by amyloid-beta is attenuated by astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033906

Risk of Alzheimer's disease and duration of NSAID use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03033906

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

21 January 2018

1 reference

12 December 2020

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

1 reference

12 December 2020

Silent brain infarcts and the risk of dementia and cognitive decline

1 reference

12 December 2020

Inhibition of endotoxin-induced nitric oxide synthase production in microglial cells by the presence of astroglial cells: a role for transforming growth factor beta

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12 December 2020

Phagocytic clearance of apoptotic neurons by Microglia/Brain macrophages in vitro: involvement of lectin-, integrin-, and phosphatidylserine-mediated recognition.

1 reference

12 December 2020

Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid

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12 December 2020

The expression of transforming growth factor-beta1 (TGF-beta1) in hippocampal neurons: a temporary upregulated protein level after transient forebrain ischemia in the rat

1 reference

12 December 2020

Amyloid-beta fibril formation is not necessarily required for microglial activation by the peptides.

1 reference

12 December 2020

Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

1 reference

12 December 2020

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

1 reference

12 December 2020

Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology

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12 December 2020

Dementia epidemiology

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12 December 2020

Pathological features of cerebral cortical capillaries are doubled in Alzheimer's disease and Parkinson's disease.

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12 December 2020

Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation.

1 reference

12 December 2020

Increased intrathecal TGF-beta1, but not IL-12, IFN-gamma and IL-10 levels in Alzheimer's disease patients.

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12 December 2020

Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death.

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12 December 2020

Toxicity of amyloid beta peptide: tales of calcium, mitochondria, and oxidative stress

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12 December 2020

Pro-inflammatory conditions promote neuronal damage mediated by Amyloid Precursor Protein and decrease its phagocytosis and degradation by microglial cells in culture

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12 December 2020

Infiltration of the brain by pathogens causes Alzheimer's disease

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12 December 2020

Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways

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12 December 2020

Dystrophic microglia in the aging human brain

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12 December 2020

Dependence of neurones on astrocytes in a coculture system renders neurones sensitive to transforming growth factor beta1-induced glutamate toxicity

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12 December 2020

Microglial secretion products and their impact on the nervous system.

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12 December 2020

The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease

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12 December 2020

The origins of Alzheimer disease: a is for amyloid.

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12 December 2020

Increased beta-secretase activity and expression in rats following transient cerebral ischemia

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12 December 2020

Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism

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12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

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12 December 2020

Chronic glial activation, neurodegeneration, and APP immunoreactive deposits following acute administration of double-stranded RNA.

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12 December 2020

Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease

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12 December 2020

Alzheimer disease as a vascular disorder: nosological evidence

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12 December 2020

Microglia as a source and target of cytokines

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12 December 2020

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice

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12 December 2020

Synaptic vesicle transport and synaptic membrane transporter sites in excitatory amino acid nerve terminals in Alzheimer disease

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12 December 2020

Peripheral cytokine release in Alzheimer patients: correlation with disease severity

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12 December 2020

Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism.

1 reference

12 December 2020

Functional Genomic Analysis of Remyelination Reveals Importance of Inflammation in Oligodendrocyte Regeneration

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12 December 2020

Brain inflammatory response induced by intracerebroventricular infusion of lipopolysaccharide: an immunohistochemical study

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12 December 2020

Glial cytokines in Alzheimer's disease: Review and pathogenic implications

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12 December 2020

Brain glia release factors with opposing actions upon neuronal survival.

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12 December 2020

Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro.

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12 December 2020

Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease

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12 December 2020

Astrocytes contribute to neuronal impairment in beta A toxicity increasing apoptosis in rat hippocampal neurons.

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12 December 2020

RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides

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12 December 2020

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

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12 December 2020

Microglia derived from aging mice exhibit an altered inflammatory profile.

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12 December 2020

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

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12 December 2020

Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain

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12 December 2020

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

1 reference

12 December 2020

Large-scale microarray studies of gene expression in multiple regions of the brain in schizophrenia and Alzheimer's disease

1 reference

12 December 2020

Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease

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12 December 2020

Beta amyloid toxicity does not require RAGE protein

1 reference

12 December 2020

Microglial interleukin-1 alpha expression in human head injury: correlations with neuronal and neuritic beta-amyloid precursor protein expression

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12 December 2020

Role of macrophage activation in the pathogenesis of Alzheimer's disease and human immunodeficiency virus type 1-associated dementia

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

A dual role for interleukin-1 in LTP in mouse hippocampal slices

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12 December 2020

The microglial phagocytic role with specific plaque types in the Alzheimer disease brain

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12 December 2020

Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells.

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12 December 2020

Characterization of glial cultures from rapid autopsies of Alzheimer's and control patients.

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12 December 2020

Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies

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12 December 2020

beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.

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12 December 2020

Gene polymorphisms of interleukin-1alpha influence the course of Alzheimer's disease

1 reference

12 December 2020

Increased neuronal beta-amyloid precursor protein expression in human temporal lobe epilepsy: association with interleukin-1 alpha immunoreactivity

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12 December 2020

Alzheimer's disease: the two-hit hypothesis

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12 December 2020

Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology

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12 December 2020

Temporal profile of microglial response following transient (2 h) middle cerebral artery occlusion

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12 December 2020

Microglia-astrocyte interaction in Alzheimer's disease: friends or foes for the nervous system?

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12 December 2020

In-vivo measurement of activated microglia in dementia

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12 December 2020

Cyclooxygenase-independent actions of cyclooxygenase inhibitors

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12 December 2020

Inflammation, autotoxicity and Alzheimer disease

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12 December 2020

Alzheimer's disease is a synaptic failure

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12 December 2020

Dexamethasone inhibits TNF-alpha synthesis more effectively in Alzheimer's disease patients than in healthy individuals.

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12 December 2020

Transforming growth factor-beta 1 produced by hippocampal cells modulates microglial reactivity in culture.

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12 December 2020

Comorbidity in dementia: an autopsy study

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12 December 2020

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

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12 December 2020

Interleukin-1 beta inhibits glutamate release in hippocampus of young, but not aged, rats.

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12 December 2020

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

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12 December 2020

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

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12 December 2020

A glia-derived signal regulating neuronal differentiation.

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12 December 2020

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

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12 December 2020

Role of insulin-like growth factor I signaling in neurodegenerative diseases.

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12 December 2020

Increased expression of TGF-beta 1 in brain tissue after ischemic stroke in humans

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12 December 2020

Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide

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12 December 2020

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

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12 December 2020

Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease

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12 December 2020

Microglial reactivity to beta-amyloid is modulated by astrocytes and proinflammatory factors

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12 December 2020

Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms.

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12 December 2020

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells

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12 December 2020

Glial responses to steroids as markers of brain aging

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12 December 2020

Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice

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12 December 2020

Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease.

1 reference

12 December 2020

Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release.

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12 December 2020

Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation

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12 December 2020

Apolipoprotein E in neurology

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12 December 2020

Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF.

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12 December 2020

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor.

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12 December 2020

Inflammation in neurodegenerative disease--a double-edged sword

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12 December 2020

Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma

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12 December 2020

Inflammation and Alzheimer's disease

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12 December 2020

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

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12 December 2020

Amyloid beta vaccination: reduced plaques and improved cognition.

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12 December 2020

Immobilized amyloid precursor protein constructs: a tool for the in vitro screening of glial cell reactivity

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12 December 2020

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

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12 December 2020

The amyloid precursor protein in ischemic brain injury and chronic hypoperfusion

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12 December 2020

Interleukin 1 in the brain: biology, pathology and therapeutic target

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12 December 2020

Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death

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12 December 2020

Microglia as neuroprotective, immunocompetent cells of the CNS.

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12 December 2020

Neurons induce the activation of microglial cells in vitro

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12 December 2020

Microglial interleukin-1 alpha expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution.

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12 December 2020

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12 December 2020

A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease.

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12 December 2020

Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid[25-35].

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12 December 2020

Glial-derived proteins activate cultured astrocytes and enhance beta amyloid-induced glial activation

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12 December 2020

TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs

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12 December 2020

Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity.

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12 December 2020

Protection of rat primary hippocampal cultures from A beta cytotoxicity by pro-inflammatory molecules is mediated by astrocytes.

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12 December 2020

Cyclooxygenase and inflammation in Alzheimer's disease: experimental approaches and clinical interventions

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12 December 2020

Region-Specific Neurotrophin Imbalances in Alzheimer Disease

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12 December 2020

Innate immunity: the missing link in neuroprotection and neurodegeneration?

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12 December 2020

TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination.

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12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

Apoptosis in neurodegenerative disorders

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12 December 2020

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

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12 December 2020

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

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12 December 2020

Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling.

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12 December 2020

Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer's disease.

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12 December 2020

Cytotoxic fragment of amyloid precursor protein accumulates in hippocampus after global forebrain ischemia.

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12 December 2020

Subacute NO generation induced by Alzheimer's beta-amyloid in the living brain: reversal by inhibition of the inducible NO synthase

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12 December 2020

"Inflammatory" cytokines: neuromodulators in normal brain?

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12 December 2020

Anti-inflammatory drugs protect against Alzheimer disease at low doses.

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12 December 2020

Direct signaling from astrocytes to neurons in cultures of mammalian brain cells

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12 December 2020

APP processing and synaptic function

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12 December 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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12 December 2020

Neuro-glia interaction effects on GFAP gene: a novel role for transforming growth factor-beta1.

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12 December 2020

Shift from anti- to proinflammatory cytokine profiles in microglia through LPS- or IFN-gamma-mediated pathways

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12 December 2020

Pro- and anti-inflammatory cytokines regulate the ERK pathway: implication of the timing for the activation of microglial cells

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12 December 2020

Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity.

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12 December 2020

The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APP(SW) mice.

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12 December 2020

Astrocyte protection of neurons: role of transforming growth factor-beta signaling via a c-Jun-AP-1 protective pathway

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12 December 2020

Upregulation of the macrophage scavenger receptor in response to different forms of injury in the CNS

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12 December 2020

Dysregulation of IFN-gamma signaling pathways in the absence of TGF-beta 1

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12 December 2020

Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor

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12 December 2020

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12 December 2020

Neuroinflammation in Alzheimer's disease and prion disease.

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12 December 2020

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

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12 December 2020

Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures

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12 December 2020

Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage.

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12 December 2020

Microglia cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plague degradation

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12 December 2020

The nitric oxide hypothesis of brain aging

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12 December 2020

Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.

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12 December 2020

Oligodendrocytes damage in Alzheimer's disease: beta amyloid toxicity and inflammation.

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12 December 2020

Neuroinflammatory perspectives on the two faces of Alzheimer's disease

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12 December 2020

Microglial activation by components of gram-positive and -negative bacteria: distinct and common routes to the induction of ion channels and cytokines.

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12 December 2020

Neuroinflammatory signaling upregulation in Alzheimer's disease

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12 December 2020

Amyloid-beta-induced chemokine production in primary human macrophages and astrocytes

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12 December 2020

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

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12 December 2020

Modification of microglia function protects from lesion-induced neuronal alterations and promotes sprouting in the hippocampus

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12 December 2020

Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress.

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12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia.

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12 December 2020

Transforming growth factor-betas in neurodegenerative disease

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12 December 2020

CD36 mediates the innate host response to beta-amyloid

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12 December 2020

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

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12 December 2020

Glial activation in Alzheimer's disease: the role of Abeta and its associated proteins

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12 December 2020

β-AMYLOID FRAGMENT POTENTIATES IL-6 AND TNF-α SECRETION BY LPS IN ASTROCYTES BUT NOT IN MICROGLIA

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12 December 2020

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

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12 December 2020

Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection.

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12 December 2020

The pathogenesis of senile plaques

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12 December 2020

Neuronal control of the immune response in the central nervous system: linking brain immunity to neurodegeneration.

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12 December 2020

Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity.

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12 December 2020

Neuroprotection by transforming growth factor-beta1 involves activation of nuclear factor-kappaB through phosphatidylinositol-3-OH kinase/Akt and mitogen-activated protein kinase-extracellular-signal regulated kinase1,2 signaling pathways.

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12 December 2020

Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein.

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12 December 2020

Altered subcellular location of phosphorylated Smads in Alzheimer's disease

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12 December 2020

Interleukin-1: a master regulator of neuroinflammation

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12 December 2020

Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system

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12 December 2020

Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences.

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12 December 2020

Neuronal changes in normal human aging and Alzheimer's disease

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12 December 2020

beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis.

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12 December 2020

Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.

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12 December 2020

The progression of the lesions in Alzheimer disease: insights from a prospective clinicopathological study.

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12 December 2020

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

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12 December 2020

Identifiers

DOI

10.1007/BF03033906

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18 August 2017

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