(Q37062108)

18 August 2017

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title

CNTF: a target therapeutic for obesity-related metabolic disease? (English)

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18 August 2017

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Vance B Matthews

1

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18 August 2017

Mark A Febbraio

series ordinal

2

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18 August 2017

publication date

22 January 2008

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Journal of Molecular Medicine

18 August 2017

published in

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18 August 2017

volume

86

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18 August 2017

issue

4

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18 August 2017

page(s)

353-361

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Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance

18 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00109-007-0286-Y

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00109-007-0286-Y

PKC-theta knockout mice are protected from fat-induced insulin resistance

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00109-007-0286-Y

Obesity wars: molecular progress confronts an expanding epidemic

21 January 2018

1 reference

12 December 2020

Ciliary neurotrophic factor is a regulator of muscular strength in aging

1 reference

12 December 2020

The ciliary neurotrophic factor and its receptor, CNTFR alpha

1 reference

12 December 2020

Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.

1 reference

12 December 2020

Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function

1 reference

12 December 2020

Cholinergic neuronotrophic factors: intraocular distribution of trophic activity for ciliary neurons

1 reference

12 December 2020

Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice

1 reference

12 December 2020

Skeletal muscle triglyceride levels are inversely related to insulin action.

1 reference

12 December 2020

Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain

1 reference

12 December 2020

Weight-reducing effects of the plasma protein encoded by the obese gene

1 reference

12 December 2020

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors

1 reference

12 December 2020

Positional cloning of the mouse obese gene and its human homologue

1 reference

12 December 2020

Recombinant human ciliary neurotrophic factor reduces weight partly by regulating nuclear respiratory factor 1 and mitochondrial transcription factor A.

1 reference

12 December 2020

Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues

1 reference

12 December 2020

Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: microarray deoxyribonucleic acid-chip analysis of gene expression

1 reference

12 December 2020

Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses

1 reference

12 December 2020

Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase

1 reference

12 December 2020

The receptor for ciliary neurotrophic factor

1 reference

12 December 2020

Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study

1 reference

12 December 2020

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

1 reference

12 December 2020

A central role for JNK in obesity and insulin resistance

1 reference

12 December 2020

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.

1 reference

12 December 2020

A family of cytokine-inducible inhibitors of signalling

1 reference

12 December 2020

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

1 reference

12 December 2020

gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor

1 reference

12 December 2020

Neurogenesis in the hypothalamus of adult mice: potential role in energy balance

1 reference

12 December 2020

Molecular mechanisms associated with leptin resistance: n-3 polyunsaturated fatty acids induce alterations in the tight junction of the brain

1 reference

12 December 2020

Acquiring signalling specificity from the cytokine receptor gp130.

1 reference

12 December 2020

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

12 December 2020

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

1 reference

12 December 2020

New perspectives on the design of cytokines and growth factors.

1 reference

12 December 2020

Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin

1 reference

12 December 2020

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

1 reference

12 December 2020

A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group

1 reference

12 December 2020

Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

1 reference

12 December 2020

Overcoming insulin resistance with CNTF

1 reference

12 December 2020

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

1 reference

12 December 2020

The regulation and activation of ciliary neurotrophic factor signaling proteins in adipocytes

1 reference

12 December 2020

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

1 reference

12 December 2020

Pathophysiology of type 2 diabetes: rationale for different oral antidiabetic treatment strategies

1 reference

12 December 2020

The novel mechanism of recombinant human ciliary neurotrophic factor on the anti-diabetes activity

1 reference

12 December 2020

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

1 reference

12 December 2020

Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor

1 reference

12 December 2020

Techniques: new pharmacological perspectives for the leptin receptor

1 reference

12 December 2020

Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity

1 reference

12 December 2020

Dedifferentiation of adult human myoblasts induced by ciliary neurotrophic factor in vitro

1 reference

12 December 2020

Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice

1 reference

12 December 2020

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

1 reference

12 December 2020

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

1 reference

12 December 2020

Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice

1 reference

12 December 2020

CNTF genotype is associated with muscular strength and quality in humans across the adult age span

1 reference

12 December 2020

Direct effects of ciliary neurotrophic factor on brown adipocytes: evidence for a role in peripheral regulation of energy homeostasis

1 reference

12 December 2020

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

1 reference

12 December 2020

Circumventing leptin resistance for weight control

1 reference

12 December 2020

The burden of chronic disease.

1 reference

12 December 2020

Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice

1 reference

12 December 2020

Prevalence and Trends in Obesity Among US Adults, 1999-2000

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12 December 2020

CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.

1 reference

12 December 2020

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

1 reference

12 December 2020

Identification and expression cloning of a leptin receptor, OB-R

1 reference

12 December 2020

Screening for variability in the ciliary neurotrophic factor (CNTF) gene: no evidence for association with human obesity

1 reference

12 December 2020

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

1 reference

12 December 2020

A null mutation in the human CNTF gene is not causally related to neurological diseases

1 reference

12 December 2020

Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF

1 reference

12 December 2020

Purification, cloning, and expression of ciliary neurotrophic factor (CNTF).

1 reference

12 December 2020

10.1007/S00109-007-0286-Y

Identifiers

DOI

1 reference

release_dv2ftjcbjjgqvc4x2b2bnk63hm

18 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/dv2ftjcbjjgqvc4x2b2bnk63hm

24 November 2022

mapped directly with Wikidata item

1 reference