(Q37072442)

English

Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation

scientific article published on 22 October 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

metabolic profiling

1 reference

based on heuristic

inferred from title

object named as

Liza Makowski

1

0 references

Deborah M Muoio

object named as

Deborah M Muoio

8

0 references

author name string

Robert C Noland

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Timothy R Koves

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Weibing Xing

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Olga R Ilkayeva

5

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Michael J Muehlbauer

6

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Robert D Stevens

7

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

language of work or name

0 references

publication date

22 October 2008

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

23

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

586-604

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630792

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Carnitine supplementation induces acylcarnitine production in tissues of very long-chain acyl-CoA dehydrogenase-deficient mice, without replenishing low free carnitine

1 reference

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29 September 2017

PPAR alpha mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis

1 reference

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Diet-induced obesity alters protein synthesis: tissue-specific effects in fasted versus fed mice

1 reference

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Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

1 reference

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Grip strength and the metabolic syndrome: findings from the Hertfordshire Cohort Study.

1 reference

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Hypoxia-inducible factor 1 (HIF-1) pathway

1 reference

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Metabolic inflexibility in skeletal muscle: a prelude to the cardiometabolic syndrome?

1 reference

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29 September 2017

Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats

1 reference

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Nutrient signaling components controlling protein synthesis in striated muscle

1 reference

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29 September 2017

Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress

1 reference

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Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

1 reference

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Effect of PPARalpha activation of macrophages on the secretion of inflammatory cytokines in cultured adipocytes

1 reference

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Sarcopenic obesity and inflammation in the InCHIANTI study

1 reference

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Fuel metabolism in starvation

1 reference

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29 September 2017

Obesity-related derangements in metabolic regulation

1 reference

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29 September 2017

Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion

1 reference

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29 September 2017

Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-alpha activators: clinical and experimental evidence

1 reference

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29 September 2017

A phytol-enriched diet induces changes in fatty acid metabolism in mice both via PPARalpha-dependent and -independent pathways

1 reference

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29 September 2017

Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus

1 reference

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29 September 2017

Peroxisome proliferator-activated receptor alpha target genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630792

29 September 2017

Serum carnitine concentrations correlated to clinical outcome parameters in chronic hemodialysis patients

1 reference

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29 September 2017

Possible beneficial role of exercise in modulating low-grade inflammation in the elderly

1 reference

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29 September 2017

Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart

1 reference

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29 September 2017

Carnitine biosynthesis in mammals

1 reference

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29 September 2017

IL-6-like cytokines and cancer cachexia: consequences of chronic inflammation

1 reference

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29 September 2017

Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system

1 reference

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29 September 2017

Molecular enzymology of carnitine transfer and transport

1 reference

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29 September 2017

Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

1 reference

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29 September 2017

Sarcopenic obesity: does muscle loss cause fat gain? Lessons from rheumatoid arthritis and osteoarthritis.

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29 September 2017

A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders

1 reference

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29 September 2017

Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)

1 reference

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29 September 2017

A novel disease with deficiency of mitochondrial very-long-chain acyl-CoA dehydrogenase

1 reference

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29 September 2017

Molecular characterization of inherited medium-chain acyl-CoA dehydrogenase deficiency

1 reference

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29 September 2017

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

1 reference

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27 June 2018

Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression

1 reference

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27 June 2018

Characterization of carnitine and fatty acid metabolism in the long-chain acyl-CoA dehydrogenase-deficient mouse

1 reference

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27 June 2018

Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta

1 reference

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27 June 2018

Dietary L-carnitine suppresses mitochondrial branched-chain keto acid dehydrogenase activity and enhances protein accretion and carcass characteristics of swine

1 reference

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27 June 2018

Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting.

1 reference

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Effects of ciprofibrate and 2-[5-(4-chlorophenyl)pentyl]oxirane-2-carboxylate (POCA) on the distribution of carnitine and CoA and their acyl-esters and on enzyme activities in rats. Relation between hepatic carnitine concentration and carnitine acet

1 reference

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27 June 2018

A comparative metabolomic study of NHR-49 in Caenorhabditis elegans and PPAR-alpha in the mouse.

1 reference

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Systemic and distal repercussions of liver-specific peroxisome proliferator-activated receptor-alpha control of the acute-phase response

1 reference

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Insulin action on glucose and protein metabolism during L-carnitine supplementation in maintenance haemodialysis patients

1 reference

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4 September 2018

PPAR alpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation.

1 reference

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4 September 2018

Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition study.

1 reference

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4 September 2018

Carnitine revisited: potential use as adjunctive treatment in diabetes.

1 reference

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4 September 2018

Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.

1 reference

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4 September 2018

A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome.

1 reference

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4 September 2018

Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy

1 reference

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4 September 2018

Physical frailty and body composition in obese elderly men and women.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630792

4 September 2018

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630792

4 September 2018

Peroxisomal proliferator-activated receptor alpha deficiency diminishes insulin-responsiveness of gluconeogenic/glycolytic/pentose gene expression and substrate cycle flux.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630792

4 September 2018

Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630792

4 September 2018

The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630792

4 September 2018

Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630792

4 September 2018

Targeted disruption of the peroxisome proliferator-activated receptor alpha gene, PPAR alpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630792

4 September 2018

Short-chain acyl-CoA dehydrogenase deficiency associated with a lipid-storage myopathy and secondary carnitine deficiency.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630792

4 September 2018

Cardiac hypertrophy is enhanced in PPAR -/- mice in response to chronic pressure overload

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2630792

4 December 2018

Increase in hepatic carnitine acetyltransferase activity associated with peroxisomal (microbody) proliferation induced by the hypolipidemic drugs clofibrate, nafenopin, and methyl clofenapate

1 reference

https://pubmed.ncbi.nlm.nih.gov/18945875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of increased hepatic concentration of carnitine by clofibrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/18945875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the effect of intravenous L-carnitine therapy on function, structure and fatty acid metabolism of skeletal muscle in patients receiving chronic hemodialysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18945875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 stimulates gluconeogenesis in primary cultures of rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18945875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective trophic effect of L-carnitine in type I and IIa skeletal muscle fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18945875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fenofibrate modifies transaminase gene expression via a peroxisome proliferator activated receptor α-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18945875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined therapy with PPARalpha agonist and L-carnitine rescues lipotoxic cardiomyopathy due to systemic carnitine deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/18945875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18945875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beyond lipids, pharmacological PPARalpha activation has important effects on amino acid metabolism as studied in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18945875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay for free and total carnitine in human plasma using tandem mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/18945875

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1096/FJ.08-119420

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

0 references

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