(Q37080843)

18 August 2017

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title

Review: genetic models of acute myeloid leukaemia (English)

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18 August 2017

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3

B T Gjertsen

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18 August 2017

E McCormack

1

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18 August 2017

O Bruserud

series ordinal

2

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18 August 2017

language of work or name

English

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publication date

11 February 2008

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18 August 2017

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18 August 2017

volume

27

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18 August 2017

issue

27

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18 August 2017

page(s)

3765-3779

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Of mice and models: improved animal models for biomedical research

18 August 2017

cites work

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Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs

21 January 2018

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A PMLRARalpha transgene initiates murine acute promyelocytic leukemia

21 January 2018

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Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.

21 January 2018

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Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia

21 January 2018

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Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

21 January 2018

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Oncogenic K-ras in mouse models of myeloproliferative disease and acute myeloid leukemia

21 January 2018

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Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.16

Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha

21 January 2018

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Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development.

21 January 2018

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21 January 2018

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Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: a model for human AML

21 January 2018

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Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia

21 January 2018

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A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

21 January 2018

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The ETO domain is necessary for the developmental abnormalities associated with AML1-ETO expression in the hematopoietic stem cell compartment in vivo.

21 January 2018

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Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation

21 January 2018

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The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.16

The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.16

Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.16

Transgenic expression of PML/RARalpha impairs myelopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.

21 January 2018

1 reference

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Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.16

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.16

Transcriptional activation by tetracyclines in mammalian cells

21 January 2018

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Transgenesis by means of blastocyst-derived embryonic stem cell lines

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2008.16

Role of nucleophosmin in embryonic development and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

NUP98-topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

The World Health Organization classification of neoplasms of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting--Airlie House, Virginia, November, 1997.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Retroviruses and embryogenesis: microinjection of Moloney leukemia virus into midgestation mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Chromosomal position and activation of retroviral genomes inserted into the germ line of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Animal models of acute myelogenous leukaemia - development, application and future perspectives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Cytogenetics in acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Clinical importance of cytogenetics in acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Germ-line transformation of mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Conditional transgenic technologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Practice points, consensus, and controversial issues in the management of patients with newly diagnosed acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Role of cyclic AMP response element binding protein in human leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Mutant N-ras preferentially drives human CD34+ hematopoietic progenitor cells into myeloid differentiation and proliferation both in vitro and in the NOD/SCID mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Retroviruses as probes for mammalian development: allocation of cells to the somatic and germ cell lineages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

The role of FLT3 in haematopoietic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Myeloid leukemia with promyelocytic features in transgenic mice expressing hCG-NuMA-RARalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Creating a transloxation. Engineering interchromosomal translocations in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Prognostically useful gene-expression profiles in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Tools for targeted manipulation of the mouse genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Role of PML in cell growth and the retinoic acid pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARα expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Engineering chromosomal rearrangements in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

High Expression Levels of theETS-Related Gene,ERG, Predict Adverse Outcome and Improve Molecular Risk-Based Classification of Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Gene transfer into mouse embryos: production of transgenic mice by pronuclear injection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

In vivo optical imaging of acute myeloid leukemia by green fluorescent protein: time-domain autofluorescence decoupling, fluorophore quantification, and localization.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

RXR is an essential component of the oncogenic PML/RARA complex in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.16

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.16

1 reference

Dimensions Publication ID

18 August 2017

1049216459

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