(Q37084502)

18 August 2017

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title

Treatment strategies for allergy and asthma (English)

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18 August 2017

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1

Stephen T Holgate

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18 August 2017

Riccardo Polosa

2

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18 August 2017

publication date

15 February 2008

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Nature Reviews Immunology

18 August 2017

published in

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18 August 2017

volume

8

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18 August 2017

issue

3

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18 August 2017

page(s)

218-230

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T-helper cell type-2 regulation in allergic disease

18 August 2017

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The safety of immunotherapy

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Update on the current status of peptide immunotherapy

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo

31 March 2020

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31 March 2020

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31 March 2020

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Identification of the Syk kinase inhibitor R112 by a human mast cell screen

31 March 2020

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Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis

31 March 2020

1 reference

An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

1 reference

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31 March 2020

1 reference

Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling

31 March 2020

1 reference

gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation

31 March 2020

1 reference

Modifications to an Fcgamma-Fcvarepsilon fusion protein alter its effectiveness in the inhibition of FcvarepsilonRI-mediated functions

31 March 2020

1 reference

A chimeric human-cat fusion protein blocks cat-induced allergy

31 March 2020

1 reference

Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial.

31 March 2020

1 reference

Efficacy of soluble IL-4 receptor for the treatment of adults with asthma

31 March 2020

1 reference

Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma

31 March 2020

1 reference

Control of allergic reactions in mice by an active anti-murine IL-4 immunization

31 March 2020

1 reference

Novel cytokine peptide-based vaccines: an interleukin-4 vaccine suppresses airway allergic responses in mice.

31 March 2020

1 reference

Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy

31 March 2020

1 reference

31 March 2020

IL-13 effector functions

1 reference

IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts

31 March 2020

1 reference

Requirement for IL-13 independently of IL-4 in experimental asthma

31 March 2020

1 reference

IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys

31 March 2020

1 reference

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31 March 2020

1 reference

Novel Recombinant Interleukin-13 Peptide-based Vaccine Reduces Airway Allergic Inflammatory Responses in Mice

31 March 2020

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31 March 2020

1 reference

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31 March 2020

1 reference

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31 March 2020

1 reference

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

31 March 2020

1 reference

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31 March 2020

1 reference

A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma.

31 March 2020

1 reference

Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway.

31 March 2020

1 reference

Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge

31 March 2020

1 reference

Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process

31 March 2020

1 reference

The eosinophil--quo vadis?

31 March 2020

1 reference

Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics

31 March 2020

1 reference

Intravenous anti-IL-5 monoclonal antibody reduces eosinophils and tenascin deposition in allergen-challenged human atopic skin

31 March 2020

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Remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthma

31 March 2020

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Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes.

31 March 2020

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Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis.

31 March 2020

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Anti-IL-5 recombinant humanized monoclonal antibody (mepolizumab) for the treatment of atopic dermatitis.

31 March 2020

1 reference

The effects of nebulized recombinant interferon-gamma in asthmatic airways

31 March 2020

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IFN-gamma-enhanced allergen penetration across respiratory epithelium augments allergic inflammation

31 March 2020

1 reference

Clinical and immunological effects of low-dose IFN-alpha treatment in patients with corticosteroid-resistant asthma

31 March 2020

1 reference

Interferon-alphacon-1 treatment of three patients with severe glucocorticoid-dependent asthma. Effect on disease control and systemic glucocorticosteroid dose

31 March 2020

1 reference

Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus

31 March 2020

1 reference

Role of deficient type III interferon-λ production in asthma exacerbations

31 March 2020

1 reference

Exacerbations: the asthma paradox

31 March 2020

1 reference

Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response

31 March 2020

1 reference

Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization

31 March 2020

1 reference

Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis

31 March 2020

1 reference

Effects of adenovirus-expressing IL-10 in alleviating airway inflammation in asthma

31 March 2020

1 reference

On the role of the epidermal differentiation complex in ichthyosis vulgaris, atopic dermatitis and psoriasis

31 March 2020

1 reference

Keratinocyte growth factor improves alterations of lung permeability and bronchial epithelium in allergic rats

31 March 2020

1 reference

Growth factors as treatment options for intestinal inflammation

31 March 2020

1 reference

Palifermin (Kepivance) for the treatment of oral mucositis in patients with hematologic malignancies requiring hematopoietic stem cell support

31 March 2020

1 reference

Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity

31 March 2020

1 reference

Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies

31 March 2020

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Asthma control during the year after bronchial thermoplasty.

31 March 2020

1 reference

Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo

31 March 2020

1 reference

IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells: role of MAPK (Erk1/2, JNK, and p38) pathways

31 March 2020

1 reference

Interleukin-17 is a negative regulator of established allergic asthma

31 March 2020

1 reference

Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma

31 March 2020

1 reference

Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation

31 March 2020

1 reference

IL-31: a new link between T cells and pruritus in atopic skin inflammation

31 March 2020

1 reference

Role of interleukin-21 in inflammation and allergy

31 March 2020

1 reference

Thymic stromal lymphopoietin: master switch for allergic inflammation

31 March 2020

1 reference

IL-2 and IL-18 attenuation of airway hyperresponsiveness requires STAT4, IFN-gamma, and natural killer cells

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI2262

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18 August 2017

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