(Q37096732)

18 August 2017

1 reference

8 February 2021

FLIP as an anti-cancer therapeutic target (English)

1 reference

CASP8 and FADD like apoptosis regulator

18 August 2017

1 reference

7 November 2020

1 reference

8 February 2021

Jin Kuk Yang

1

1 reference

18 August 2017

1 February 2008

1 reference

PMC publication ID

2615266

18 August 2017

29 February 2008

5 references

3 April 2019

20 November 2019

28 November 2019

7 November 2020

8 February 2021

9

1 reference

inferred from page(s)

published in

Yonsei Medical Journal

6 references

18 August 2017

3 April 2019

20 November 2019

28 November 2019

7 November 2020

8 February 2021

49

1 reference

18 August 2017

1

1 reference

18 August 2017

19-27

1 reference

Creative Commons Attribution-NonCommercial 3.0 Unported

18 August 2017

5 references

3 April 2019

20 November 2019

28 November 2019

7 November 2020

on focus list of Wikimedia project

8 February 2021

ScienceSource

0 references

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Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition

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Regulation of the resistance to TRAIL-induced apoptosis as a new strategy for pancreatic cancer.

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29 September 2017

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c-FLIPR, a new regulator of death receptor-induced apoptosis.

29 September 2017

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Persistent c-FLIP(L) expression is necessary and sufficient to maintain resistance to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in prostate cancer

29 September 2017

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Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.

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29 September 2017

The flip side of FLIP

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CD95-mediated apoptosis is impaired at receptor level by cellular FLICE-inhibitory protein (long form) in wild-type p53 human ovarian carcinoma

29 September 2017

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Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro.

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Caspase activation: revisiting the induced proximity model

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Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death

29 September 2017

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c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis

29 September 2017

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Death receptors in chemotherapy and cancer

29 September 2017

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N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

29 September 2017

1 reference

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Targeting the FLICE Inhibitory Protein (FLIP) in cancer therapy.

29 September 2017

1 reference

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Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers

29 September 2017

1 reference

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The death effector domain protein family: regulators of cellular homeostasis

29 September 2017

1 reference

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Protein-based therapeutic approaches targeting death receptors

29 September 2017

1 reference

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Many cuts to ruin: a comprehensive update of caspase substrates

29 September 2017

1 reference

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Death fold domain interaction in apoptosis

29 September 2017

1 reference

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TRAIL-induced signalling and apoptosis

29 September 2017

1 reference

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Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis

29 September 2017

1 reference

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Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

29 September 2017

1 reference

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c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

29 September 2017

1 reference

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Constitutive expression of c-FLIP in Hodgkin and Reed-Sternberg cells

29 September 2017

1 reference

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Regulation of lymphocyte proliferation and death by FLIP.

29 September 2017

1 reference

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Binding of FADD and caspase-8 to molluscum contagiosum virus MC159 v-FLIP is not sufficient for its antiapoptotic function

29 September 2017

1 reference

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Alternative splicing variants of c-FLIP transduce the differential signal through the Raf or TRAF2 in TNF-induced cell proliferation

29 September 2017

1 reference

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Selective expression of FLIP in malignant melanocytic skin lesions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Characterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different flip isoforms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Human pancreatic cancer cells disable function of Fas receptors at several levels in Fas signal transduction pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Structural basis of IAP recognition by Smac/DIABLO

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

The biochemistry of apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Activation of the NF-kappaB pathway by caspase 8 and its homologs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Activation of NF-kappaB by FADD, Casper, and caspase-8.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Molecular determinants of response to TRAIL in killing of normal and cancer cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

29 September 2017

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Safety and antitumor activity of recombinant soluble Apo2 ligand

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

CASH, a novel caspase homologue with death effector domains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Inhibition of death receptor signals by cellular FLIP

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Casper is a FADD- and caspase-related inducer of apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Identification and characterization of a new member of the TNF family that induces apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Cell death: the significance of apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

c-FLIP expression in colorectal carcinomas: association with Fas/FasL expression and prognostic implications.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

c-FLIP expression in bladder urothelial carcinomas: its role in resistance to Fas-mediated apoptosis and clinicopathologic correlations

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Overexpression of cellular FLICE-inhibitory protein (FLIP) in gastric adenocarcinoma.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Increased expression of FLIP, an inhibitor of Fas‐mediated apoptosis, in stomach cancer

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Resistance of human ovarian cancer cells to tumor necrosis factor alpha is a consequence of nuclear factor kappaB-mediated induction of Fas-associated death domain-like interleukin-1beta-converting enzyme-like inhibitory protein

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Sensitization of human colon cancer cells to TRAIL-mediated apoptosis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2615266

Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signaling

3 September 2018

1 reference

12 December 2020

The structure of FADD and its mode of interaction with procaspase-8

1 reference

12 December 2020

Overexpression of FLIPL is an independent marker of poor prognosis in colorectal cancer patients

1 reference

12 December 2020

Increased expression of cFLIP(L) in colonic adenocarcinoma

1 reference

12 December 2020

A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis

1 reference

12 December 2020

Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells

1 reference

12 December 2020

Identifiers

DOI

10.3349/YMJ.2008.49.1.19

1 reference

18 August 2017

1 reference

PMC publication ID

2615266

18 August 2017

PubMed publication ID

18306465

1 reference

PMC publication ID

2615266