(Q37097757)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18700785%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

title

Mechanism of insolubilization by a single-point mutation in alphaA-crystallin linked with hereditary human cataracts (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18700785%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18700785%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

author name string

Paul D Hamilton

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18700785%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

Nathan Ravi

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18700785%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

language of work or name

English

0 references

publication date

14 August 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18700785%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18700785%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

volume

47

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18700785%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

issue

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18700785%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

page(s)

9697-9706

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18700785%20AND%20SRC:MED&resulttype=core&format=json

Differential binding of mutant (R116C) and wildtype alphaA crystallin to actin

12 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Crystallins in the eye: Function and pathology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Crystallins and hereditary cataracts: molecular mechanisms and potential for therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Role of short-range protein interactions in lens opacifications

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

The function of the beta3 interactive domain in the small heat shock protein and molecular chaperone, human alphaB crystallin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Effect of site-directed mutagenesis of methylglyoxal-modifiable arginine residues on the structure and chaperone function of human alphaA-crystallin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

A novel alphaB-crystallin mutation associated with autosomal dominant congenital lamellar cataract

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Evidence for an essential function of the N terminus of a small heat shock protein in vivo, independent of in vitro chaperone activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Light scattering in lens research: an essay on accomplishments and promises

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Ageing and vision: structure, stability and function of lens crystallins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Cell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21q

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Structure and function of the small heat shock protein/alpha-crystallin family of molecular chaperones

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Lens proteomics: analysis of rat crystallin sequences and two-dimensional electrophoresis map

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

The R116C mutation in alpha A-crystallin diminishes its protective ability against stress-induced lens epithelial cell apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Lens crystallins and their microbial homologs: structure, stability, and function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Crystal cataracts: human genetic cataract caused by protein crystallization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Molecular basis of a progressive juvenile-onset hereditary cataract

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Expression of growth control and differentiation genes in human lens epithelial cells with extended life span

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Conformational and functional differences between recombinant human lens alphaA- and alphaB-crystallin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Cloning, expression, and chaperone-like activity of human alphaA-crystallin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

The X-ray structures of two mutant crystallin domains shed light on the evolution of multi-domain proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Expression of the alpha-crystallin/small heat-shock protein/molecular chaperone genes in the lens and other tissues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Fluorescence study of the effects of aging and diabetes mellitus on human lens alpha-crystallin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Alpha-crystallin can function as a molecular chaperone

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Small heat-shock protein structures reveal a continuum from symmetric to variable assemblies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Genealogy of the alpha-crystallin--small heat-shock protein superfamily

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Spectroscopic studies on human lens crystallins

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Molecular determinants of the aggregation behavior of alpha- and beta-synuclein

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Cataract-causing alphaAG98R mutant shows substrate-dependent chaperone activity.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Cryoelectron microscopy and EPR analysis of engineered symmetric and polydisperse Hsp16.5 assemblies reveals determinants of polydispersity and substrate binding.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Decrease in protein solubility and cataract formation caused by the Pro23 to Thr mutation in human gamma D-crystallin

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Subunit exchange of small heat shock proteins. Analysis of oligomer formation of alphaA-crystallin and Hsp27 by fluorescence resonance energy transfer and site-directed truncations

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642957

Mechanism of a hereditary cataract phenotype. Mutations in alphaA-crystallin activate substrate binding

3 September 2018

1 reference

12 December 2020

Identification of a novel, putative cataract-causing allele in CRYAA (G98R) in an Indian family

1 reference

12 December 2020

N- and C-Terminal motifs in human alphaB crystallin play an important role in the recognition, selection, and solubilization of substrates

1 reference

12 December 2020

Quantitative detection of the molecular changes associated with early cataractogenesis in the living human lens using quasielastic light scattering

1 reference

12 December 2020

Temperature-induced exposure of hydrophobic surfaces and its effect on the chaperone activity of alpha-crystallin

1 reference

12 December 2020

Quasielastic light scattering study of the living human lens as a function of age

1 reference

12 December 2020

Detection and characterization of alpha-crystallin intermediate with maximal chaperone-like activity

1 reference

12 December 2020

Interaction of 1,1'-bi(4-anilino)naphthalene-5,5'-disulfonic acid with alpha-crystallin

1 reference

12 December 2020

The N-terminal arm of small heat shock proteins is important for both chaperone activity and substrate specificity

1 reference

12 December 2020

Thermodynamic stability of human lens recombinant alphaA- and alphaB-crystallins

1 reference

12 December 2020

Mutation of R116C results in highly oligomerized alpha A-crystallin with modified structure and defective chaperone-like function

1 reference

12 December 2020

Heat-induced conformational change of human lens recombinant alphaA- and alphaB-crystallins

1 reference

12 December 2020

Lens epithelial cells derived from alphaB-crystallin knockout mice demonstrate hyperproliferation and genomic instability

1 reference

12 December 2020

Decreased subunit exchange of heat-treated lens alpha A-crystallin

1 reference

12 December 2020

Site-directed spin labeling study of subunit interactions in the alpha-crystallin domain of small heat-shock proteins. Comparison of the oligomer symmetry in alphaA-crystallin, HSP 27, and HSP 16.3.

1 reference

12 December 2020

Identifiers

DOI

10.1021/BI800594T

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18700785%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18700785%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

PubMed publication ID

18700785

1 reference