(Q37128667)

18 August 2017

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title

Mice as clinically relevant models for the study of cytochrome P450-dependent metabolism (English)

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18 August 2017

S Muruganandan

1

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18 August 2017

C J Sinal

series ordinal

2

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18 August 2017

language of work or name

English

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publication date

19 March 2008

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Clinical Pharmacology & Therapeutics

18 August 2017

published in

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18 August 2017

volume

83

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18 August 2017

issue

6

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18 August 2017

page(s)

818-828

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Near completely humanized liver in mice shows human-type metabolic responses to drugs

18 August 2017

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Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

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Paroxetine, a cytochrome P450 2D6 inhibitor, diminishes the stereoselective O-demethylation and reduces the hypoalgesic effect of tramadol

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7 January 2021

Acute rejection and massive cyclosporine requirements in heart transplant recipients treated with rifampin

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Acute heart transplant rejection due to Saint John's wort

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Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response

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How many deaths occur annually from adverse drug reactions in the United States?

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Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species

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Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man

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7 January 2021

Functionally defective or altered CYP3A4 and CYP3A5 single nucleotide polymorphisms and their detection with genotyping tests

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Human cytochrome p450 family 4 enzymes: function, genetic variation and regulation

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Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2

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Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism

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Study of P450 function using gene knockout and transgenic mice

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Role of CYP1A2 and CYP2E1 in the pentoxifylline ciprofloxacin drug interaction

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Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2.

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4-aminobiphenyl-induced liver and urinary bladder DNA adduct formation in Cyp1a2(-/-) and Cyp1a2(+/+) mice

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7 January 2021

Effects of CYP1A2 on disposition of 2,3,7, 8-tetrachlorodibenzo-p-dioxin, 2,3,4,7,8-pentachlorodibenzofuran, and 2,2',4,4',5,5'-hexachlorobiphenyl in CYP1A2 knockout and parental (C57BL/6N and 129/Sv) strains of mice

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7 January 2021

CYP1A2 is not required for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunosuppression

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Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

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Reduction of toxic metabolite formation of acetaminophen

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Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis

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7 January 2021

Hepatic and pulmonary microsomal benzene metabolism in CYP2E1 knockout mice

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7 January 2021

Acetone catabolism by cytochrome P450 2E1: studies with CYP2E1-null mice.

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7 January 2021

Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.

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7 January 2021

Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus

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7 January 2021

Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice.

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7 January 2021

Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line

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7 January 2021

The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.

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Polymorphic hydroxylation of Debrisoquine in man.

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7 January 2021

Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

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7 January 2021

Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase

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7 January 2021

Prevalence of patients using drugs metabolized by cytochrome P450 2D6 in different populations: a cross-sectional study.

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7 January 2021

CYP2D6 polymorphism: implications for antipsychotic drug response, schizophrenia and personality traits

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7 January 2021

Oxidative stress, toxicology, and pharmacology of CYP2E1.

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7 January 2021

Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage

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7 January 2021

The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity

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7 January 2021

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Expression of the Human CYP3A4 Gene in the Small Intestine of Transgenic Mice: In Vitro Metabolism and Pharmacokinetics of Midazolam

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7 January 2021

Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice.

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7 January 2021

CYP3A4 and pregnane X receptor humanized mice

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7 January 2021

Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice

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7 January 2021

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7 January 2021

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7 January 2021

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism

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7 January 2021

Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus

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7 January 2021

Application of chimeric mice with humanized liver for predictive ADME.

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7 January 2021

Identifiers

DOI

10.1038/CLPT.2008.50

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18 August 2017

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