(Q37139471)

18 August 2017

Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern (English)

1 reference

18 August 2017

1 reference

Peter H Hagedorn

1

1 reference

18 August 2017

Victor Yakimov

2

1 reference

18 August 2017

Søren Ottosen

3

1 reference

18 August 2017

Susanne Kammler

4

1 reference

18 August 2017

Niels F Nielsen

5

1 reference

18 August 2017

Anja M Høg

6

1 reference

18 August 2017

Maj Hedtjärn

7

1 reference

18 August 2017

Michael Meldgaard

8

1 reference

18 August 2017

Marianne R Møller

9

1 reference

18 August 2017

Henrik Orum

10

1 reference

18 August 2017

Troels Koch

11

1 reference

18 August 2017

Morten Lindow

12

1 reference

18 August 2017

16 August 2013

1 reference

Nucleic Acid Therapeutics

18 August 2017

1 reference

18 August 2017

23

1 reference

18 August 2017

5

1 reference

18 August 2017

302-310

1 reference

Treatment of HCV infection by targeting microRNA

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Chemical modification study of antisense gapmers

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Pathogenic mechanisms of myotonic dystrophy

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Quantifying biogenic bias in screening libraries

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Therapeutic potential of Toll-like receptor 9 activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Do preclinical testing strategies help predict human hepatotoxic potentials?

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Navigating chemical space for biology and medicine

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Putting the Predictive Toxicology Challenge into perspective: reflections on the results.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Further development and validation of empirical scoring functions for structure-based binding affinity prediction

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Physicochemical properties of phosphorothioate oligodeoxynucleotides

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

Chemically modified oligonucleotides exhibit decreased immune stimulation in mice.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3760025

The Oligonucleotide Safety Working Group (OSWG)

27 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23952551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23952551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Assessing unintended hybridization-induced biological effects of oligonucleotides

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23952551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1089/NAT.2013.0436

1 reference

18 August 2017

1 reference

18 August 2017

PubMed publication ID

23952551

1 reference