(Q37157896)

18 August 2017

1 reference

title

Pharmacogenetics of immunosuppressive drugs: prospect of individual therapy for transplant patients (English)

1 reference

ORCID Public Data File 2021

18 August 2017

1 reference

author name string

Nasirul J Ekbal

series ordinal

1

1 reference

PubMed ID

18466104

18 August 2017

David W Holt

series ordinal

2

1 reference

PubMed ID

18466104

18 August 2017

Iain Am Macphee

series ordinal

3

1 reference

18 August 2017

1 May 2008

1 reference

18 August 2017

1 reference

18 August 2017

9

1 reference

18 August 2017

5

1 reference

18 August 2017

585-596

1 reference

Organ transplantation--how much of the promise has been realized?

18 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Immunosuppressive drugs for kidney transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Adequate early cyclosporin exposure is critical to prevent renal allograft rejection: patients monitored by absorption profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

The natural history of chronic allograft nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

New-Onset Diabetes After Transplantation 2003 International Consensus Guidelines: an endocrinologist's view.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Therapeutic drug monitoring of sirolimus: correlations with efficacy and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Therapeutic drug monitoring of immunosuppressive drugs in kidney transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Pharmacogenetics as a tool for optimising drug therapy in solid-organ transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

The pharmacogenetics of calcineurin inhibitors: one step closer toward individualized immunosuppression?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Pharmacogenetics in transplant patients: can it predict pharmacokinetics and pharmacodynamics?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Racial variation in dosage requirements of tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Racial differences in renal transplantation after immunosuppression with tacrolimus versus cyclosporine. FK506 Kidney Transplant Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

In vitro metabolism of cyclosporine A by human kidney CYP3A5.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

The effect of gut metabolism on tacrolimus bioavailability in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Cyclosporin-erythromycin interaction in renal transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Clinical pharmacokinetics and therapeutic drug monitoring of sirolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Cytochrome P450 3A4 and P-glycoprotein activity and assimilation of tacrolimus in transplant patients with persistent diarrhea

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Genotyping cytochrome P450 3A5 using the Light Cycler.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

CYP3A variation and the evolution of salt-sensitivity variants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

A "silent" polymorphism in the MDR1 gene changes substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and P-glycoprotein correlate with dose requirement

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Tacrolimus pharmacogenetics: the CYP3A5*1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Genetic polymorphisms in MDR1 and CYP3A5 and MDR1 haplotype in mainland Chinese Han, Uygur and Kazakh ethnic groups

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

CYP3A gene expression in human gut epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Expression of cytochrome P450 3A in amphibian, rat, and human kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Induction of multidrug resistance-1 and cytochrome P450 mRNAs in human mononuclear cells by rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Intestinal MDR1/ABCB1 level at surgery as a risk factor of acute cellular rejection in living-donor liver transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

The effect of variable CYP3A5 expression on cyclosporine dosing, blood pressure and long-term graft survival in renal transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

ABCB1 genotype of the donor but not of the recipient is a major risk factor for cyclosporine-related nephrotoxicity after renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Calcineurin inhibitor-induced nephrotoxicity and renal expression of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Association between ABCB1 (multidrug resistance transporter) genotype and post-liver transplantation renal dysfunction in patients receiving calcineurin inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

CYP3A5 genotype does not influence the blood concentration of tacrolimus measured with the Abbott immunoassay.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Effect of the CYP3A5 genotype on the pharmacokinetics of intravenous midazolam during inhibited and induced metabolic states.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

CYP3A5*3 influences sirolimus oral clearance in de novo and stable renal transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Sirolimus and tacrolimus trough concentrations and dose requirements after kidney transplantation in relation to CYP3A5 and MDR1 polymorphisms and steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

CYP3A5*1-carrying graft liver reduces the concentration/oral dose ratio of tacrolimus in recipients of living-donor liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

A randomized long-term trial of tacrolimus and sirolimus versus tacrolimus and mycophenolate mofetil versus cyclosporine (NEORAL) and sirolimus in renal transplantation. I. Drug interactions and rejection at one year

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Differential pharmacokinetic interaction of tacrolimus and cyclosporine on everolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Modulation of multidrug-resistant multiple myeloma by cyclosporin. The Leukaemia Group of the EORTC and the HOVON

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Sequential analysis of tacrolimus dosing in adult lung transplant patients with ABCB1 haplotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Genetic analysis of steroid-induced osteonecrosis of the femoral head.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Tissue glucocorticoid resistance/hypersensitivity syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Azathioprine metabolism: pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

TPMT genotype and its clinical implication in renal transplant recipients with azathioprine treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Enteric-coated mycophenolate sodium is therapeutically equivalent to mycophenolate mofetil in de novo renal transplant patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Regulation of inosine-5'-monophosphate dehydrogenase type II gene expression in human T cells. Role for a novel 5' palindromic octamer sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Pre-transplant inosine monophosphate dehydrogenase activity is associated with clinical outcome after renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Isolation and characterization of mycophenolic acid-resistant mutants of inosine-5'-monophosphate dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Genetic and nongenetic determinants of between-patient variability in the pharmacokinetics of mycophenolic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Pharmacokinetic interaction between corticosteroids and tacrolimus after renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Liver regeneration in recipients and donors after transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Auxiliary partial orthotopic living donor liver transplantation as an aid for small-for-size grafts in larger recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Characterization of hepatic cytochrome p4503A activity in patients with end-stage renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Downregulation of intestinal cytochrome p450 in chronic renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Twelve-month evaluation of the clinical pharmacokinetics of total and free mycophenolic acid and its glucuronide metabolites in renal allograft recipients on low dose tacrolimus in combination with mycophenolate mofetil

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Sequence diversity and haplotype structure at the human CYP3A cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

Detection of cardiac allograft rejection and response to immunosuppressive therapy with peripheral blood gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

The influence of CYP3A gene polymorphisms on cyclosporine dose requirement in renal allograft recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.9.5.585

21 January 2018

Identifiers

DOI

10.2217/14622416.9.5.585

1 reference

18 August 2017

1 reference

PubMed ID

18466104