(Q37163177)

English

Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity

scientific article published on April 2009

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scholarly article

1 reference

Europe PubMed Central

18 August 2017

Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity (English)

1 reference

Europe PubMed Central

18 August 2017

0 references

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Chi Chen

1

1 reference

Europe PubMed Central

18 August 2017

Kristopher W Krausz

2

1 reference

Europe PubMed Central

18 August 2017

Yatrik M Shah

3

1 reference

Europe PubMed Central

18 August 2017

Jeffrey R Idle

4

1 reference

Europe PubMed Central

18 August 2017

Frank J Gonzalez

5

1 reference

Europe PubMed Central

18 August 2017

publication date

1 April 2009

1 reference

Europe PubMed Central

18 August 2017

Chemical Research in Toxicology

1 reference

Europe PubMed Central

18 August 2017

22

1 reference

Europe PubMed Central

18 August 2017

699-707

1 reference

Europe PubMed Central

18 August 2017

4

1 reference

Europe PubMed Central

18 August 2017

Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

LC-MS-based metabolomics in drug metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

Modulation of PPAR activity via phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

Fatty acid transduction of nitric oxide signaling: multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

The role of the carnitine system in human metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

Carnitine-acylcarnitine translocase deficiency, clinical, biochemical and genetic aspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

Hepatic gene expression and lipid homeostasis in C57BL/6 mice exposed to hydrazine or acetylhydrazine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

Long-chain hydroxydicarboxylic aciduria, carnitine depletion and acetaminophen exposure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

6 September 2017

Carnitine-acylcarnitine translocase deficiency: implications in human pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

14 September 2017

Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

14 September 2017

Cytochrome P-4502E1: its physiological and pathological role

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

29 September 2017

Paracetamol inhibits nitric oxide synthesis in murine spinal cord slices.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

27 June 2018

Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

27 June 2018

Protection against acetaminophen hepatotoxicity by a single dose of clofibrate: effects on selective protein arylation and glutathione depletion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

27 June 2018

Mechanisms of fasting-induced potentiation of acetaminophen hepatotoxicity in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

27 June 2018

Surplus acylcarnitines in the plasma of starved rats derive from the liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

27 June 2018

The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

3 September 2018

Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

3 September 2018

Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

3 September 2018

Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

3 September 2018

An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

3 September 2018

Serum phosphate is an early predictor of outcome in severe acetaminophen-induced hepatotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

3 September 2018

Screening for carnitine palmitoyltransferase II deficiency by tandem mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

3 September 2018

Genomics and proteomics analysis of acetaminophen toxicity in mouse liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

3 September 2018

Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

3 September 2018

The PPAR activator docosahexaenoic acid prevents acetaminophen hepatotoxicity in male CD-1 mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

3 September 2018

N-acetyl-p-benzoquinone imine-induced changes in the energy metabolism in hepatocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

3 September 2018

Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670930

20 October 2018

Regulation of peroxisome proliferator activated receptor alpha-mediated pathways in alcohol fed cytochrome P450 2E1 deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19256530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acylcarnitines in plasma and blood spots of patients with long-chain 3-hydroxyacyl-coenzyme A dehydrogenase defiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/19256530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum enzyme activities and hepatic triglyceride levels in acute and subacute acetaminophen-treated rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19256530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of CYP2E1 in the hepatotoxicity of acetaminophen

1 reference

https://pubmed.ncbi.nlm.nih.gov/19256530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19256530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatoprotective effect of L-carnitine against acute acetaminophen toxicity in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19256530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetaminophen-induced hepatic glycogen depletion and hyperglycemia in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19256530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19256530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a 54-kDa mitochondrial acetaminophen-binding protein as aldehyde dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19256530

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/TX800464Q

1 reference

Europe PubMed Central

18 August 2017

1 reference

Europe PubMed Central

18 August 2017

1 reference

Europe PubMed Central

18 August 2017

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