(Q37164434)

English

The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance

scientific article published on May 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Andrea B. Troxel

object named as

Andrea B Troxel

7

0 references

Trevor M Penning

object named as

Trevor M Penning

9

0 references

author name string

Jong-Heum Park

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Stacy Gelhaus

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Srilakshmi Vedantam

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Andrea L Oliva

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Abhita Batra

5

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Ian A Blair

6

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Jeffrey Field

8

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

publication date

1 May 2008

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Chemical Research in Toxicology

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

21

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

5

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

1039-1049

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection

1 reference

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Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair

1 reference

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Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products

1 reference

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Poleta, Polzeta and Rev1 together are required for G to T transversion mutations induced by the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells

1 reference

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Generation of mutator mutants during carcinogenesis

1 reference

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Origins and selection of p53 mutations in lung carcinogenesis

1 reference

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The TP53 gene, tobacco exposure, and lung cancer

1 reference

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Human lung cancer and p53: the interplay between mutagenesis and selection

1 reference

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Transcription coupled repair of 8-oxoguanine in murine cells: the ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences

1 reference

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Dominant-negative mutations of the tumor suppressor p53 relating to early onset of glioblastoma multiforme

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Tobacco smoke carcinogens and lung cancer

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6 September 2017

A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

1 reference

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6 September 2017

Cytosine methylation determines hot spots of DNA damage in the human P53 gene

1 reference

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6 September 2017

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

1 reference

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6 September 2017

Dominant-negative p53 mutations selected in yeast hit cancer hot spots

1 reference

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6 September 2017

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2

1 reference

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6 September 2017

The causes and prevention of cancer

1 reference

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6 September 2017

A simple p53 functional assay for screening cell lines, blood, and tumors

1 reference

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6 September 2017

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1 reference

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6 September 2017

p53 mutations in human cancers

1 reference

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6 September 2017

Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers

1 reference

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14 September 2017

Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671329

14 September 2017

Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671329

14 September 2017

Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment

1 reference

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Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study

1 reference

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14 September 2017

Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671329

14 September 2017

Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671329

27 June 2018

Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling

1 reference

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27 June 2018

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

1 reference

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Letter: Benzo[a]pyrene-nucleic acid derivative found in vivo: structure of a benzo[a]pyrenetetrahydrodiol epoxide-guanosine adduct

1 reference

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Nucleoside adducts from the in vitro reaction of benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide or benzo[a]pyrene 4,5-oxide with nucleic acids

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p53: a two-faced cancer gene.

1 reference

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p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

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Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers.

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Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas.

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AKR1B10: a new diagnostic marker of non-small cell lung carcinoma in smokers

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1 reference

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1 reference

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Mutagenesis of Benzo[a]pyrene Diol Epoxide in Yeast: Requirement for DNA Polymerase ζ and Involvement of DNA Polymerase η

1 reference

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Simulated sunlight and benzo[a]pyrene diol epoxide induced mutagenesis in the human p53 gene evaluated by the yeast functional assay: lack of correspondence to tumor mutation spectra

1 reference

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On the origin of p53 G:C --> T:A transversions in lung cancers

1 reference

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Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach

1 reference

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Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53.

1 reference

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Tumour p53 mutations exhibit promoter selective dominance over wild type p53.

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3 September 2018

Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671329

3 September 2018

The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2671329

3 September 2018

Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung

1 reference

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3 September 2018

Overexpression of dihydrodiol dehydrogenase as a prognostic marker of non-small cell lung cancer

1 reference

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3 September 2018

Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones.

1 reference

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3 September 2018

Inactivation of OGG1 increases the incidence of G . C-->T . A transversions in Saccharomyces cerevisiae: evidence for endogenous oxidative damage to DNA in eukaryotic cells.

1 reference

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3 September 2018

Dose-dependent differences in the profile of mutations induced by (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in Chinese hamster V-79 cells

1 reference

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3 September 2018

The reaction of (±)-7α, 8β-dihydroxy-9β, 10β-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with dna

1 reference

https://pubmed.ncbi.nlm.nih.gov/18489080

12 December 2020

based on heuristic

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Binding of Nenzo[ a ]pyrene 7,8-Diol-9,10-Epoxides to DNA, RNA, and Protein of Mouse Skin Occurs with High Stereoselectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18489080

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Screening patients for heterozygous p53 mutations using a functional assay in yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/18489080

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide as a carcinogen: analysis by yeast functional assay of inactivating p53 mutations induced by nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18489080

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p53 gene mutation: software and database

1 reference

https://pubmed.ncbi.nlm.nih.gov/18489080

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione

1 reference

https://pubmed.ncbi.nlm.nih.gov/18489080

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18489080

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/18489080

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/TX700404A

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

0 references

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