(Q37196126)

English

The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation

scientific article published on 27 February 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

11

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

author name string

Yvonne S Lin

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Kazuto Yasuda

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Mahfoud Assem

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Cynthia Cline

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Joe Barber

5

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Chia-Wei Li

6

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Vladyslav Kholodovych

7

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Ni Ai

8

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

J Don Chen

9

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

William J Welsh

10

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Erin G Schuetz

12

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

publication date

27 February 2009

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Drug Metabolism and Disposition

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

37

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

6

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

1295-1304

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Intrinsic disorder in nuclear hormone receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Active nuclear receptors exhibit highly correlated AF-2 domain motions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Evolution of pharmacologic specificity in the pregnane X receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Evolution of the bile salt nuclear receptor FXR in vertebrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Functional evolution of the vitamin D and pregnane X receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Human PXR forms a tryptophan zipper-mediated homodimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Structure and function of the human nuclear xenobiotic receptor PXR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Functional and structural comparison of PXR and CAR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Identification of the novel splicing variants for the hPXR in human livers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Intrinsically disordered protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Functional and structural characterization of the insertion region in the ligand binding domain of the vitamin D nuclear receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

6 September 2017

Identification of a truncated alternative splicing variant of human PPARgamma1 that exhibits dominant negative activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

14 September 2017

Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

14 September 2017

Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

26 June 2018

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

3 September 2018

Identification of amino acids in rat pregnane X receptor that determine species-specific activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

3 September 2018

Promiscuous regulator of xenobiotic removal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2683691

3 September 2018

Optimizing long intrinsic disorder predictors with protein evolutionary information

1 reference

https://pubmed.ncbi.nlm.nih.gov/19251824

12 December 2020

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Identifiers

10.1124/DMD.108.025213

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

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