(Q37208315)

18 August 2017

1 reference

title

Complementing mutations in core binding factor leukemias: from mouse models to clinical applications (English)

1 reference

18 August 2017

A M S Müller

1

1 reference

18 August 2017

J Duque

series ordinal

2

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18 August 2017

J A Shizuru

series ordinal

3

1 reference

18 August 2017

M Lübbert

series ordinal

4

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18 August 2017

language of work or name

English

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publication date

7 July 2008

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18 August 2017

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18 August 2017

volume

27

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18 August 2017

issue

44

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18 August 2017

page(s)

5759-5773

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https://scigraph.springernature.com/pub.10.1038/onc.2008.196

18 August 2017

exact match

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cites work

The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor alpha (CBFalpha) subunit by the leukemia-related PEBP2/CBFbeta-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Fluorescence in situ hybridization identifies cryptic t(16;16)(p13;q22) masked by del(16)(q22) in a case of AML-M4 Eo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Common themes in the pathogenesis of acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Implications of NRAS mutations in AML: a study of 2502 patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

C-Kit point mutations in core binding factor leukemias: correlation with white blood cell count and the white blood cell index

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Gene targeting reveals a crucial role for MTG8 in the gut.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

AML1-FOG2 fusion protein in myelodysplasia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Identification of the novel AML1 fusion partner gene, LAF4, a fusion partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) by bubble PCR method for cDNA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Detection of CBFbeta/MYH11 fusion transcripts in acute myeloid leukemia: heterogeneity of cytological and molecular characteristics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

c-kit proto-oncogene exon 8 in-frame deletion plus insertion mutations in acute myeloid leukaemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

An activated receptor tyrosine kinase, TEL/PDGFbetaR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Tyrosine kinase mutations of JAK2 are rare events in AML but influence prognosis of patients with CBF-leukemias

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Genetics of myeloid leukemias

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

KIT exon 8 mutations associated with core-binding factor (CBF)-acute myeloid leukemia (AML) cause hyperactivation of the receptor in response to stem cell factor.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Identification of additional cytogenetic and molecular genetic abnormalities in acute myeloid leukaemia with t(8;21)/AML1-ETO

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Impact of FLT3 mutations and promyelocytic leukaemia-breakpoint on clinical characteristics and prognosis in acute promyelocytic leukaemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

The JAK2 V617F mutation in de novo acute myelogenous leukemias.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Leukemogenic AML1-ETO fusion protein upregulates expression of connexin 43: the role in AML 1-ETO-induced growth arrest in leukemic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Oncogenic transcription factors in the human acute leukemias

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Inducible expression of AML1-ETO fusion protein endows leukemic cells with susceptibility to extrinsic and intrinsic apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Molecular analysis of PDGFRalpha/beta genes in core binding factor leukemia with eosinophilia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Cytogenetics in acute leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Comparison of cytogenetic and molecular genetic detection of t(8;21) and inv(16) in a prospective series of adults with de novo acute myeloid leukemia: a Cancer and Leukemia Group B Study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Mutations in the receptor tyrosine kinase pathway are associated with clinical outcome in patients with acute myeloblastic leukemia harboring t(8;21)(q22;q22).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Imatinib mesylate for refractory acute myeloblastic leukemia harboring inv(16) and a C-KIT exon 8 mutation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

A white blood cell index as the main prognostic factor in t(8;21) acute myeloid leukemia (AML): a survey of 161 cases from the French AML Intergroup

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

A novel and cytogenetically cryptic t(7;21)(p22;q22) in acute myeloid leukemia results in fusion of RUNX1 with the ubiquitin-specific protease gene USP42.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

The 8;21 translocation in leukemogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Individual patient data-based meta-analysis of patients aged 16 to 60 years with core binding factor acute myeloid leukemia: a survey of the German Acute Myeloid Leukemia Intergroup

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

JAK2 seems to be a typical cooperating mutation in therapy-related t(8;21)/ AML1-ETO-positive AML

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

JAK2V617F as progression marker in CMPD and as cooperative mutation in AML with trisomy 8 and t(8;21): a comparative study on 1103 CMPD and 269 AML cases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.196

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.196

1 reference

18 August 2017

1 reference