(Q37215415)

19 August 2017

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title

Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus (English)

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19 August 2017

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Ralph A DeFronzo

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19 August 2017

Muhammad A Abdul-Ghani

series ordinal

1

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19 August 2017

1 June 2008

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19 August 2017

Current diabetes report

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19 August 2017

8

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19 August 2017

3

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19 August 2017

173-178

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https://scigraph.springernature.com/pub.10.1007/s11892-008-0030-1

19 August 2017

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cites work

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11892-008-0030-1

Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle.

21 January 2018

1 reference

12 December 2020

Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women

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12 December 2020

Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria

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12 December 2020

Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle

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12 December 2020

Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

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12 December 2020

Adaptations of skeletal muscle to endurance exercise and their metabolic consequences

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12 December 2020

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

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12 December 2020

The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes

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12 December 2020

Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes

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12 December 2020

Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients

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12 December 2020

Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress.

1 reference

12 December 2020

Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients

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12 December 2020

Large energetic adaptations of elderly muscle to resistance and endurance training

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12 December 2020

The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus

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12 December 2020

Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle

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12 December 2020

Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects.

1 reference

12 December 2020

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

1 reference

12 December 2020

Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity

1 reference

12 December 2020

Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis

1 reference

12 December 2020

Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach

1 reference

12 December 2020

Mitochondrial dysfunction induces aberrant insulin signalling and glucose utilisation in murine C2C12 myotube cells

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12 December 2020

Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes

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12 December 2020

Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity

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12 December 2020

Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by PPARgamma agonists.

1 reference

12 December 2020

A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis

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12 December 2020

Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice

1 reference

12 December 2020

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

12 December 2020

Lipid oxidation is reduced in obese human skeletal muscle

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12 December 2020

Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes

1 reference

12 December 2020

An allosteric model for the inhibition of glucokinase by long chain acyl coenzyme A

1 reference

12 December 2020

Impaired plasma fatty acid oxidation in extremely obese women

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12 December 2020

Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance

1 reference

12 December 2020

The effect of concurrent endurance and strength training on quantitative estimates of subsarcolemmal and intermyofibrillar mitochondria

1 reference

12 December 2020

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

1 reference

12 December 2020

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

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12 December 2020

Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients

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12 December 2020

Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes

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12 December 2020

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents

1 reference

12 December 2020

Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia

1 reference

12 December 2020

Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects

1 reference

12 December 2020

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

1 reference

12 December 2020

Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss

1 reference

12 December 2020

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

1 reference

12 December 2020

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

1 reference

12 December 2020

Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart.

1 reference

12 December 2020

Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance

1 reference

12 December 2020

Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies

1 reference

12 December 2020

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

1 reference

12 December 2020

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

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12 December 2020

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

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12 December 2020

Impact of exercise training on insulin sensitivity, physical fitness, and muscle oxidative capacity in first-degree relatives of type 2 diabetic patients

1 reference

12 December 2020

Metabolic and molecular basis of insulin resistance

1 reference

12 December 2020

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

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12 December 2020

Does impaired mitochondrial function affect insulin signaling and action in cultured human skeletal muscle cells?

1 reference

12 December 2020

Banting lecture 1988. Role of insulin resistance in human disease

1 reference

12 December 2020

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1

1 reference

12 December 2020

Mechanism of palmityl coenzyme A inhibition of liver glycogen synthase

1 reference

12 December 2020

Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity

1 reference

12 December 2020

Fuel selection in human skeletal muscle in insulin resistance: a reexamination

1 reference

12 December 2020

Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion

1 reference

12 December 2020

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

1 reference

12 December 2020

Mitochondrial dysfunction and type 2 diabetes

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12 December 2020

10.1007/S11892-008-0030-1

Identifiers

DOI

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19 August 2017

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PubMed ID

18625112