(Q37272092)

19 August 2017

1 reference

title

The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease (English)

1 reference

inflammatory bowel diseases

19 August 2017

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Theodore S Steiner

4

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Megan K. Levings

object named as

Megan K Levings

5

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author name string

Megan E Himmel

1

1 reference

19 August 2017

Gijs Hardenberg

2

1 reference

19 August 2017

Ciriaco A Piccirillo

3

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19 August 2017

publication date

1 October 2008

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19 August 2017

number of pages

9

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inferred from page(s)

published in

Immunology

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19 August 2017

volume

125

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19 August 2017

issue

2

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19 August 2017

page(s)

145-153

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Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25-CD4+ T cells.

19 August 2017

cites work

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3 September 2018

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Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.

3 September 2018

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The genetics and immunopathogenesis of inflammatory bowel disease

3 September 2018

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Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6.

3 September 2018

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MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis.

3 September 2018

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Burkholderia pseudomallei infection of T cells leads to T-cell costimulation partially provided by flagellin

3 September 2018

1 reference

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The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease.

3 September 2018

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TLR ligand suppression or enhancement of Treg cells? A double-edged sword in immunity to tumours

3 September 2018

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Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier.

3 September 2018

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Deletion of TLR5 results in spontaneous colitis in mice

3 September 2018

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Therapeutic impact of toll-like receptors on inflammatory bowel diseases: a multiple-edged sword

3 September 2018

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Regulatory T cells and toll-like receptors: regulating the regulators

3 September 2018

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Toll-like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells

3 September 2018

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Isolation of flagellated bacteria implicated in Crohn's disease.

3 September 2018

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Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

3 September 2018

1 reference

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The fundamental basis of inflammatory bowel disease

3 September 2018

1 reference

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Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

3 September 2018

1 reference

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CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells

3 September 2018

1 reference

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Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis

3 September 2018

1 reference

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Transient regulatory T-cells: a state attained by all activated human T-cells.

3 September 2018

1 reference

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Inflammatory bowel disease: is it really just another break in the wall?

3 September 2018

1 reference

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Expression and function of Toll-like receptors in T lymphocytes

3 September 2018

1 reference

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How flagellin and toll-like receptor 5 contribute to enteric infection

3 September 2018

1 reference

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Lipopolysaccharide-activated CD4+CD25+ T regulatory cells inhibit neutrophil function and promote their apoptosis and death

3 September 2018

1 reference

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The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

TLRs in the Gut. III. Immune responses to flagellin in Crohn's disease: good, bad, or irrelevant?

3 September 2018

1 reference

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Humoral immune response to flagellin requires T cells and activation of innate immunity

3 September 2018

1 reference

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Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

3 September 2018

1 reference

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Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling

3 September 2018

1 reference

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

3 September 2018

1 reference

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Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells

3 September 2018

1 reference

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Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

3 September 2018

1 reference

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An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis.

3 September 2018

1 reference

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Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis

3 September 2018

1 reference

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Toll-like receptor 2 controls expansion and function of regulatory T cells

3 September 2018

1 reference

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Toll-like receptor 9 signaling protects against murine lupus

3 September 2018

1 reference

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Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis

3 September 2018

1 reference

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Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

3 September 2018

1 reference

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Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells.

3 September 2018

1 reference

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Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

In vivo CpG DNA/toll-like receptor 9 interaction induces regulatory properties in CD4+CD62L+ T cells which prevent intestinal inflammation in the SCID transfer model of colitis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

3 September 2018

1 reference

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Elevated flagellin-specific immunoglobulins in Crohn's disease

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease

3 September 2018

1 reference

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Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy

3 September 2018

1 reference

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Crohn's disease is associated with a toll-like receptor-9 polymorphism

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences

3 September 2018

1 reference

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Toll-like receptor ligands directly promote activated CD4+ T cell survival

3 September 2018

1 reference

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Bacterial flagellin is a dominant antigen in Crohn disease.

3 September 2018

1 reference

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Human intestinal microvascular endothelial cells express Toll-like receptor 5: a binding partner for bacterial flagellin

3 September 2018

1 reference

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Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

3 September 2018

1 reference

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TLR2 is expressed on activated T cells as a costimulatory receptor

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

Toll-like receptors: balancing host resistance with immune tolerance

3 September 2018

1 reference

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A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

3 September 2018

1 reference

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Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide

3 September 2018

1 reference

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CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms

3 September 2018

1 reference

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Inhibition of human CD4(+)CD25(+high) regulatory T cell function

3 September 2018

1 reference

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The immunology of mucosal models of inflammation

3 September 2018

1 reference

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Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines.

3 September 2018

1 reference

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

The C3H/HeJBir mouse model: a high susceptibility phenotype for colitis

3 September 2018

1 reference

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T cell specificity and cross reactivity towards enterobacteria, bacteroides, bifidobacterium, and antigens from resident intestinal flora in humans

3 September 2018

1 reference

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CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease

3 September 2018

1 reference

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Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

3 September 2018

1 reference

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CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells

3 September 2018

1 reference

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CD4+CD25+ Regulatory T Cells Cure Murine Colitis: The Role of IL-10, TGF-β, and CTLA4

20 October 2018

1 reference

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Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells

20 October 2018

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Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease

21 January 2018

1 reference

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21 January 2018

1 reference

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The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2561137

TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-theta signaling and promote autoimmune myocarditis

3 December 2018

1 reference

12 December 2020

Cutting edge: TLR2 directly triggers Th1 effector functions

1 reference

12 December 2020

Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta

1 reference

12 December 2020

Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signaling

1 reference

12 December 2020

FOXP3 regulates TLR10 expression in human T regulatory cells

1 reference

12 December 2020

Enteric bacterial antigens activate CD4(+) T cells from scid mice with inflammatory bowel disease

1 reference

12 December 2020

The Toll-Like Receptor 5 Stimulus Bacterial Flagellin Induces Maturation and Chemokine Production in Human Dendritic Cells

1 reference

12 December 2020

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

1 reference

12 December 2020

Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients

1 reference

12 December 2020

Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora

1 reference

12 December 2020

Probiotics in inflammatory bowel disease: new insight to pathogenesis or a possible therapeutic alternative?

1 reference

12 December 2020

Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease

1 reference

12 December 2020

Decreased numbers of FoxP3-positive and TLR-2-positive cells in intestinal mucosa are associated with improvement in patients with active inflammatory bowel disease following selective leukocyte apheresis

1 reference

12 December 2020

TNF alpha production to TLR2 ligands in active IBD patients

1 reference

12 December 2020

Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity

1 reference

12 December 2020

Role of toll-like receptors in spontaneous commensal-dependent colitis

1 reference

12 December 2020

Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis

1 reference

12 December 2020

10.1111/J.1365-2567.2008.02939.X

Identifiers

DOI

1 reference

19 August 2017

0 references

1 reference