(Q37310983)

19 August 2017

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title

Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover (English)

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19 August 2017

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Neil O Carragher

1

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publication date

29 October 2008

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Clinical & Experimental Metastasis

19 August 2017

published in

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19 August 2017

volume

26

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19 August 2017

issue

4

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19 August 2017

page(s)

381-397

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Calpain activity is generally elevated during transformation but has oncogene-specific biological functions

19 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS10585-008-9222-Y

Identification and characterization of a novel cytoskeleton-associated pp60src substrate

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10585-008-9222-Y

An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-008-9222-Y

Object-oriented image analysis for high content screening: detailed quantification of cells and sub cellular structures with the Cellenger software

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10585-008-9222-Y

Role of extracellular matrix proteins in regulation of human glioma cell invasion in vitro.

21 January 2018

1 reference

12 December 2020

Dynamic microtubules regulate the local concentration of E-cadherin at cell-cell contacts

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12 December 2020

Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells

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12 December 2020

Tumor cell migration in three dimensions

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12 December 2020

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

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12 December 2020

Turning all the lights on: quantum dots in cellular assays

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12 December 2020

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

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12 December 2020

Illuminating adhesion complexes in migrating cells: moving toward a bright future

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12 December 2020

Integrin α3β1-Dependent Activation of FAK/Src Regulates Rac1-Mediated Keratinocyte Polarization on Laminin-5

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12 December 2020

Gelatinase-mediated migration and invasion of cancer cells

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12 December 2020

In vivo imaging of integrin alpha v beta 3 expression using fluorescence-mediated tomography

1 reference

12 December 2020

Marking synaptic activity in dendritic spines with a calpain substrate exhibiting fluorescence resonance energy transfer

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12 December 2020

Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior

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12 December 2020

Fluorescent indicators for imaging protein phosphorylation in single living cells

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12 December 2020

Understanding effects of matrix protease and matrix organization on directional persistence and translational speed in three-dimensional cell migration.

1 reference

12 December 2020

Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model

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12 December 2020

Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors

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12 December 2020

Molecular imaging of MMP expression and therapeutic MMP inhibition

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12 December 2020

Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding

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12 December 2020

Microscopic imaging techniques for drug discovery

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12 December 2020

Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis

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12 December 2020

Selective regulation of integrin--cytoskeleton interactions by the tyrosine kinase Src.

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12 December 2020

Regulation of cell migration by the calcium-dependent protease calpain

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12 December 2020

ADAMs: modulators of cell–cell and cell–matrix interactions

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12 December 2020

A guide to choosing fluorescent proteins

1 reference

12 December 2020

An unbiased cell morphology-based screen for new, biologically active small molecules

1 reference

12 December 2020

Intravital imaging of cell movement in tumours

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12 December 2020

Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments

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12 December 2020

Cellular imaging in drug discovery

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12 December 2020

Tumour-cell invasion and migration: diversity and escape mechanisms

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12 December 2020

Fos-transformation activates genes associated with invasion.

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12 December 2020

Use of TIRF microscopy to visualize actin and microtubules in migrating cells

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12 December 2020

In vivo mammalian brain imaging using one- and two-photon fluorescence microendoscopy

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12 December 2020

Nanometer targeting of microtubules to focal adhesions

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12 December 2020

Regulation of integrin-mediated adhesion during cell migration

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12 December 2020

In vivo cancer targeting and imaging with semiconductor quantum dots

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12 December 2020

Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53.

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12 December 2020

Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy

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12 December 2020

Ovarian carcinoma regulation of matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase through beta1 integrin

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12 December 2020

Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells

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12 December 2020

Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility

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12 December 2020

Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOP.

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12 December 2020

Dynamic Actin Patterns and Arp2/3 Assembly at the Substrate-Attached Surface of Motile Cells

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12 December 2020

Regulation of protrusion shape and adhesion to the substratum during chemotactic responses of mammalian carcinoma cells

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12 December 2020

Cell migration strategies in 3-D extracellular matrix: differences in morphology, cell matrix interactions, and integrin function

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12 December 2020

Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion

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12 December 2020

Identification and in vivo efficacy of small-molecule antagonists of integrin alphavbeta3 (the vitronectin receptor).

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12 December 2020

Actin and microtubule cytoskeletons of the processes of 3D-cultured MC3T3-E1 cells and osteocytes

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12 December 2020

Behavioral profiling of human transitional cell carcinoma ex vivo

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12 December 2020

A genetically encoded photosensitizer

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12 December 2020

Adaptive optics in microscopy

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12 December 2020

Mechanisms of tumour invasion and metastasis: emerging targets for therapy

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12 December 2020

Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells.

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12 December 2020

Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system

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12 December 2020

Integrin trafficking and its role in cancer metastasis

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12 December 2020

Fluorescence lifetime imaging microscope consisting of a compact picosecond dye laser and a gated charge-coupled device camera for applications to living cells.

1 reference

12 December 2020

Metastatic dissemination of human ovarian epithelial carcinoma is promoted by alpha2beta1-integrin-mediated interaction with type I collagen

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12 December 2020

Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion

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12 December 2020

MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts.

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12 December 2020

Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors

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12 December 2020

Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5

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12 December 2020

Direct, dynamic assessment of cell-matrix interactions inside fibrillar collagen lattices

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12 December 2020

Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop

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12 December 2020

Engineering and characterization of a superfolder green fluorescent protein

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12 December 2020

Measuring cell motility using quantum dot probes

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12 December 2020

MALDI imaging mass spectrometry: molecular snapshots of biochemical systems

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12 December 2020

In situ photoactivation of a caged phosphotyrosine peptide derived from focal adhesion kinase temporarily halts lamellar extension of single migrating tumor cells.

1 reference

12 December 2020

Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET(B) receptor-mediated G(i)- and G(q)-pathways and MAP kinase activation

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12 December 2020

Molecular complexity and dynamics of cell-matrix adhesions

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12 December 2020

Genetically targeted chromophore-assisted light inactivation

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12 December 2020

Two-photon imaging to a depth of 1000 microm in living brains by use of a Ti:Al2O3 regenerative amplifier

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12 December 2020

Reaching out for signals: filopodia sense EGF and respond by directed retrograde transport of activated receptors

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12 December 2020

Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function.

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12 December 2020

Role of metalloproteinases MMP-9 and MT1-MMP in CXCL12-promoted myeloma cell invasion across basement membranes

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12 December 2020

Analysis of integrin signaling by fluorescence resonance energy transfer

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12 December 2020

A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods

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12 December 2020

Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397.

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12 December 2020

Proteolysis of cortactin by calpain regulates membrane protrusion during cell migration

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12 December 2020

Differential regulation of cell motility and invasion by FAK

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12 December 2020

Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis

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12 December 2020

Illuminating the metastatic process

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12 December 2020

Tumor cells caught in the act of invading: their strategy for enhanced cell motility.

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12 December 2020

Innovation: Photoactivatable fluorescent proteins.

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12 December 2020

v-Src's hold over actin and cell adhesions

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12 December 2020

Multidimensional drug profiling by automated microscopy.

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12 December 2020

Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talin

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12 December 2020

The fluorescent toolbox for assessing protein location and function

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12 December 2020

Cell migration into a wounded area in vitro

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12 December 2020

Identification of metastasis candidate proteins among HCC cell lines by comparative proteome and biological function analysis of S100A4 in metastasis in vitro

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12 December 2020

Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex

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12 December 2020

FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

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12 December 2020

Melanoma invasion - current knowledge and future directions

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12 December 2020

ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo

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12 December 2020

The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon

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12 December 2020

Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies.

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12 December 2020

Prespecification and plasticity: shifting mechanisms of cell migration

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12 December 2020

Unligated epidermal growth factor receptor forms higher order oligomers within microclusters on A431 cells that are sensitive to tyrosine kinase inhibitor binding.

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12 December 2020

Calpain-mediated proteolysis of talin regulates adhesion dynamics

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12 December 2020

Chromophore-assisted laser inactivation (CALI) to elucidate cellular mechanisms of cancer

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12 December 2020

Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins.

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12 December 2020

Direct Interaction of Focal Adhesion Kinase with p190RhoGEF

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12 December 2020

Spatial and temporal regulation of focal adhesion kinase activity in living cells.

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12 December 2020

Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.

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12 December 2020

A new detection algorithm for image analysis of single, fluorescence-labeled proteins in living cells

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12 December 2020

Optically sectioned fluorescence lifetime imaging using a Nipkow disk microscope and a tunable ultrafast continuum excitation source.

1 reference

12 December 2020

Development of a quantitative method to analyse tumour cell invasion in organotypic culture

1 reference

12 December 2020

Novel multiwavelength microscopic scanner for mouse imaging

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12 December 2020

Molecular imaging in drug discovery and development

1 reference

12 December 2020

10.1007/S10585-008-9222-Y

Identifiers

DOI

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19 August 2017

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