(Q37328121)

English

Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress

scientific article published on September 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

photoactivation

0 references

endoplasmic reticulum

0 references

author name string

Aparna Kaul

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

William A Maltese

2

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 September 2009

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

11

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

9

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

823-834

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

Executioner caspase-3 and caspase-7 are functionally distinct proteases

1 reference

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Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis

1 reference

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Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs

1 reference

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IRE1 signaling affects cell fate during the unfolded protein response

1 reference

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Classical PKC isoforms in cancer

1 reference

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Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib.

1 reference

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6 September 2017

ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1.

1 reference

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6 September 2017

Mediators of endoplasmic reticulum stress-induced apoptosis

1 reference

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Preclinical and clinical development of novel agents that target the protein kinase C family

1 reference

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Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress.

1 reference

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United States Food and Drug Administration approval summary: bortezomib for the treatment of progressive multiple myeloma after one prior therapy

1 reference

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Caspases 3 and 7: key mediators of mitochondrial events of apoptosis

1 reference

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6 September 2017

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

1 reference

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6 September 2017

Coupling endoplasmic reticulum stress to the cell death program

1 reference

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6 September 2017

Roles of CHOP/GADD153 in endoplasmic reticulum stress

1 reference

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6 September 2017

Protein kinase C: a target for anticancer drugs?

1 reference

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6 September 2017

Regulation of the expression and processing of caspase-12

1 reference

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6 September 2017

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

1 reference

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6 September 2017

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

1 reference

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Human VPS34 is required for internal vesicle formation within multivesicular endosomes

1 reference

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6 September 2017

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

6 September 2017

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

6 September 2017

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

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6 September 2017

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

6 September 2017

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

1 reference

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6 September 2017

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

1 reference

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The Ras-related GTP-binding protein, Rab1B, regulates early steps in exocytic transport and processing of beta-amyloid precursor protein

1 reference

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

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6 September 2017

Calphostin C-induced apoptosis is mediated by a tissue transglutaminase-dependent mechanism involving the DLK/JNK signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

14 September 2017

Photoexcited calphostin C selectively destroys nuclear lamin B1 in neoplastic human and rat cells - a novel mechanism of action of a photodynamic tumor therapy agent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

14 September 2017

Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib

1 reference

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14 September 2017

Distinct mechanism of cell death is responsible for tunicamycin-induced ER stress in SK-N-SH and SH-SY5Y cells.

1 reference

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14 September 2017

Apoptosis signalling mechanisms in human cancer cells induced by Calphostin-PDT.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

14 September 2017

Gene silencing reveals a specific function of hVps34 phosphatidylinositol 3-kinase in late versus early endosomes

1 reference

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14 September 2017

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

1 reference

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14 September 2017

Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

1 reference

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Antimyeloma activity of heat shock protein-90 inhibition.

1 reference

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14 September 2017

Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis

1 reference

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14 September 2017

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.

1 reference

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14 September 2017

Potent killing of paclitaxel- and doxorubicin-resistant breast cancer cells by calphostin C accompanied by cytoplasmic vacuolization

1 reference

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14 September 2017

Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation

1 reference

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28 September 2017

Potent direct inhibition of mammalian phospholipase D isoenzymes by calphostin-c

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

28 September 2017

Calphostin C triggers calcium-dependent apoptosis in human acute lymphoblastic leukemia cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

28 September 2017

Calphostin C induces selective disassembly of the Golgi complex by a protein kinase C-independent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

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The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro

1 reference

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Protein kinase C: a novel target for inhibiting gastric cancer cell invasion

1 reference

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1 reference

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Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor

1 reference

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28 September 2017

Deletion analysis of protein kinase C inactivation by calphostin C.

1 reference

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1 reference

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Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

1 reference

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1 reference

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Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

26 June 2018

Inhibition of protein kinase C by calphostin C is light-dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

26 June 2018

Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

2 September 2018

Targeting the protein kinase C family: are we there yet?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

2 September 2018

NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

2 September 2018

Combination celecoxib and temozolomide in C6 rat glioma orthotopic model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

2 September 2018

Dimethyl celecoxib as a novel non-cyclooxygenase 2 therapy in the treatment of non-small cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

2 September 2018

Caspase-12: an overview

1 reference

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2 September 2018

Induction of the mitochondrial permeability transition mediates the killing of HeLa cells by staurosporine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

2 September 2018

Calphostin C-mediated translocation and integration of Bax into mitochondria induces cytochrome c release before mitochondrial dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

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Growth inhibition induced by Ro 31-8220 and calphostin C in human glioblastoma cell lines is associated with apoptosis and inhibition of CDC2 kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2735803

2 September 2018

Expression of Rab3A GTPase and other synaptic proteins is induced in differentiated NT2N neurons

1 reference

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2 September 2018

A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19724676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/19724676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/19724676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/19724676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C

1 reference

https://pubmed.ncbi.nlm.nih.gov/19724676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidic acid formation by phospholipase D is required for transport from the endoplasmic reticulum to the Golgi complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19724676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated calphostin C cytotoxicity is independent of p53 status and in vivo metastatic potential

1 reference

https://pubmed.ncbi.nlm.nih.gov/19724676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90 inhibition by geldanamycin and proteasome inhibition by velcade

1 reference

https://pubmed.ncbi.nlm.nih.gov/19724676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Golgi complex disassembly caused by light-activated calphostin C involves MAPK and PKA

1 reference

https://pubmed.ncbi.nlm.nih.gov/19724676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19724676

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1593/NEO.09388

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

ResearchGate publication ID

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