(Q37330718)

19 August 2017

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title

ErbB receptors and cell polarity: new pathways and paradigms for understanding cell migration and invasion (English)

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19 August 2017

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Michael E Feigin

1

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author name string

Senthil K Muthuswamy

series ordinal

2

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PubMed ID

19022245

19 August 2017

language of work or name

English

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publication date

5 November 2008

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Experimental Cell Research

19 August 2017

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19 August 2017

315

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19 August 2017

707-716

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19 August 2017

4

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The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis

19 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

7 January 2021

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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

7 January 2021

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Activation of ErbB3-PI3-kinase pathway is correlated with malignant phenotypes of adenocarcinomas

7 January 2021

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The ErbB receptors and their role in cancer progression.

7 January 2021

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The ErbB signaling network: receptor heterodimerization in development and cancer

7 January 2021

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Identification of heregulin, a specific activator of p185erbB2

7 January 2021

1 reference

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Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

7 January 2021

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A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor

7 January 2021

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Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

7 January 2021

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Biochemical characterization of the protein tyrosine kinase homology domain of the ErbB3 (HER3) receptor protein

7 January 2021

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The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions

7 January 2021

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Cancer cell motility--on the road from c-erbB-2 receptor steered signaling to actin reorganization

7 January 2021

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Untangling the ErbB signalling network

7 January 2021

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Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells

7 January 2021

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Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin.

7 January 2021

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Co-expression of epidermal growth factor receptor and transforming growth factor-α is independent of ras mutations in lung adenocarcinoma

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Complex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-alpha in human prostate cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Expression of transforming growth factor-alpha and epidermal growth factor receptor in gastrointestinal stromal tumours

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

EGFR antagonists in cancer treatment

7 January 2021

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Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

The neu gene: an erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Amplification of a novel v-erbB-related gene in a human mammary carcinoma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Targeting HER proteins in cancer therapy and the role of the non-target HER3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Epidermal growth factor promotes the chemotactic migration of cultured rat intestinal epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-alpha and epidermal growth factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Epidermal growth factor (EGF) increases the in vitro invasion, motility and adhesion interactions of the primary renal carcinoma cell line, A704.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

EGF receptor signaling enhances in vivo invasiveness of DU-145 human prostate carcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

ErbB3-dependent motility and intravasation in breast cancer metastasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

The EGF receptor is an actin-binding protein

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Stimulation of beta1-integrin function by epidermal growth factor and heregulin-beta has distinct requirements for erbB2 but a similar dependence on phosphoinositide 3-OH kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Targeting phosphoinositide 3-kinase: moving towards therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

ErbB2 promotes Src synthesis and stability: novel mechanisms of Src activation that confer breast cancer metastasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

FAK integrates growth-factor and integrin signals to promote cell migration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Phosphorylation of FAK, PI-3K, and impaired actin organization in CK-positive micrometastatic breast cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Epidermal growth factor-regulated activation of Rac GTPase enhances CD44 cleavage by metalloproteinase disintegrin ADAM10.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

p38MAPK induces cell surface alpha4 integrin downregulation to facilitate erbB-2-mediated invasion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Adaptation of core mechanisms to generate cell polarity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Parsing the polarity code

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

The PAR-aPKC system: lessons in polarity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Asymmetric T lymphocyte division in the initiation of adaptive immune responses.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

A Genetic Screen in Drosophila for Metastatic Behavior

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Expression of Dickkopf genes is strongly reduced in malignant melanoma

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Loss of Hugl-1 expression associates with lymph node metastasis in endometrial cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Phosphorylation and free pool of beta-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-beta during the process of epithelial to mesenchymal transition in rat proximal epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2008.10.034

10.1016/J.YEXCR.2008.10.034

7 January 2021

Identifiers

DOI

1 reference

19 August 2017

1 reference

PubMed ID

19022245